Results 21 to 30 of about 7,198,263 (194)

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer. [PDF]

Proc Natl Acad Sci U S A, 2013
The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1,6-fucosylation in mammals, has been observed in several malignant cancers including liver, ovarian, thyroid, and colorectal cancers. However, the pathological role and the regulatory mechanism of FUT8 in cancers remain largely unknown.
Chen CY, Jan YH, Juan YH, Yang CJ, Huang MS, Yu CJ, Yang PC, Hsiao M, Hsu TL, Wong CH.   +9 more
europepmc   +4 more sources

Fucosyltransferase 8 deficiency suppresses breast cancer cell migration by interference of the FAK/integrin pathway. [PDF]

Cancer Biomark, 2019
BACKGROUND AND OBJECTIVE: Fucosyltranferase 8 (FUT8), which catalyzes core fucosylation of glycopeptides, plays important roles in cancer development. In this study, we aimed to explore the influence of FUT8 expression on migration ability of human breast cancer cells and its potential mechanisms.
Liu D, Gao Z, Yue L.
europepmc   +3 more sources

Subcellular localisation of cerebral fucosyltransferase. [PDF]

, 1984
International audienceGDP-fucose: asialofetuin fucosyltransferase from sheep brain was fractionated on a sucrose gradient into two activity peaks. Using purification on Ficoll adapted from the proposed method [(1980) J. Neurochem.
Broquet, P., Baubichon-Cortay, H., Peschard, Mj, Serres-Guillaumond, M., Louisot, P.   +4 more
core   +3 more sources

Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema [PDF]

Journal of Human Genetics, 2011
The fucosyltransferase 8 gene (FUT8) encodes an enzyme that transfers fucose to the innermost N-acetylglucosamine unit of N-glycan chains. Recent study showed that fut8-deficient mice develop pathological and physiological phenotypes resembling pulmonary emphysema (PE). The role of FUT8 in human PE is not known.
Miki, Yamada, Takeo, Ishii, Shinobu, Ikeda, Makiko, Naka-Mieno, Noriko, Tanaka, Tomio, Arai, Toshio, Kumasaka, Akihiko, Gemma, Kozui, Kida, Masaaki, Muramatsu, Motoji, Sawabe   +10 more
openaire   +2 more sources

Advances in the study of core fucosylation in mammals

浙江大学学报. 农业与生命科学版, 2021
Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase.
TIAN Yinping, YI Wen
doaj   +1 more source

Fucosylation Promotes Cytolytic Function and Accumulation of NK Cells in B Cell Lymphoma

Frontiers in Immunology, 2022
Natural killer (NK) cells have been demonstrated as a promising cellular therapy as they exert potent anti-tumor immune responses. However, applications of NK cells to tumor immunotherapy, especially in the treatment of advanced hematopoietic and solid ...
Xing Tong, Xing Tong, Xing Tong, Xing Tong, Yuhua Ru, Yuhua Ru, Yuhua Ru, Jianhong Fu, Jianhong Fu, Jianhong Fu, Ying Wang, Ying Wang, Ying Wang, Jinjin Zhu, Jinjin Zhu, Jinjin Zhu, Yiyang Ding, Yiyang Ding, Yiyang Ding, Fulian Lv, Fulian Lv, Fulian Lv, Menglu Yang, Menglu Yang, Menglu Yang, Xiya Wei, Xiya Wei, Xiya Wei, Chenchen Liu, Chenchen Liu, Chenchen Liu, Xin Liu, Xin Liu, Xin Liu, Lei Lei, Lei Lei, Lei Lei, Xiaojin Wu, Xiaojin Wu, Xiaojin Wu, Lingchuan Guo, Yang Xu, Yang Xu, Yang Xu, Jie Li, Peng Wu, Huanle Gong, Huanle Gong, Huanle Gong, Jia Chen, Jia Chen, Jia Chen, Depei Wu, Depei Wu, Depei Wu   +54 more
doaj   +1 more source

FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Cell Death and Disease, 2023
Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC.
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang   +20 more
doaj   +1 more source

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source

Diagnosis and prognosis of serum Fut8 for epilepsy and refractory epilepsy in children

PLoS ONE, 2023
With adequate serum concentration of antiepileptic drugs, the epilepsy symptoms in many patients still cannot be controlled well. The alteration of glycosyltransferase has obvious influence on the pathogenesis of epilepsy.
Yunxiu Huang, Zhou Zhang, Linmu Chen
doaj   +2 more sources

The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro

Scientific Reports, 2023
Glycosylation of proteins and lipids in viruses and their host cells is important for viral infection and is a target for antiviral therapy. Hepatitis B virus (HBV) is a major pathogen that causes acute and chronic hepatitis; it cannot be cured because ...
Tsunenori Ouchida, Haruka Maeda, Yuka Akamatsu, Megumi Maeda, Shinji Takamatsu, Jumpei Kondo, Ryo Misaki, Yoshihiro Kamada, Masahiro Ueda, Keiji Ueda, Eiji Miyoshi   +10 more
doaj   +1 more source