Results 21 to 30 of about 74,907,945 (195)

FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer [PDF]

, 2021
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation.
Jennifer Munkley, David J. Elliott, Kayla Bastian, Emma Scott   +3 more
core   +4 more sources

Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity

Molecular Therapy: Methods & Clinical Development, 2021
The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the use of
James M. Termini, José M. Martinez-Navio, Guangping Gao, Sebastian P. Fuchs, Ronald C. Desrosiers   +4 more
doaj   +1 more source

IgG1-Dominant Antibody Response Induced by Recombinant Trimeric SARS-CoV-2 Spike Protein with PIKA Adjuvant

Vaccines, 2023
Recombinant trimeric SARS-CoV-2 Spike protein with PIKA (polyI:C) adjuvant induces potent and durable neutralizing antibodies that protect against multiple SARS-CoV-2 variants. The immunoglobulin subclasses of viral-specific antibodies remain unknown, as
Jingxia Wang, Xinjia Mai, Yu He, Chenxi Zhu, Dapeng Zhou   +4 more
doaj   +1 more source

Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema [PDF]

Journal of Human Genetics, 2011
The fucosyltransferase 8 gene (FUT8) encodes an enzyme that transfers fucose to the innermost N-acetylglucosamine unit of N-glycan chains. Recent study showed that fut8-deficient mice develop pathological and physiological phenotypes resembling pulmonary emphysema (PE). The role of FUT8 in human PE is not known.
Miki, Yamada, Takeo, Ishii, Shinobu, Ikeda, Makiko, Naka-Mieno, Noriko, Tanaka, Tomio, Arai, Toshio, Kumasaka, Akihiko, Gemma, Kozui, Kida, Masaaki, Muramatsu, Motoji, Sawabe   +10 more
openaire   +2 more sources

An essential, kinetoplastid-specific GDP-Fuc:β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei [PDF]

, 2021
Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar GDP-Fuc has been ...
Ferguson, Michael A.J., Jose Carlos Paredes Franco, Ferguson, Michael Aj, Damerow, Sebastian, Guo, Hongjie, Sebastian Damerow, Ferguson, Michael A. J.; id_orcid, Maria Lucia Sempaio Guther, Beverley, Stephen, Stephen Beverley, Hongjie Guo, Angela Mehlert, Bandini, Giulia, Sempaio Güther, Maria Lucia, Michael AJ Ferguson, Paredes Franco, Jose Carlos, Mehlert, Angela, Giulia Bandini   +17 more
core   +1 more source

Identification of new fucosyltransferase-8 inhibitors: An integrated biochemical, biophysical, and computational approach [PDF]

PLoS ONE
Muhammad Awais, Noor Rahman, Sumaira Javaid, Atia-tul- Wahab, Thirugnanasambandam Rajendran, M. Iqbal Choudhary, Humaira Zafar   +6 more
doaj   +1 more source

Advances in the study of core fucosylation in mammals

浙江大学学报. 农业与生命科学版, 2021
Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase.
TIAN Yinping, YI Wen
doaj   +1 more source

Fucosylation Promotes Cytolytic Function and Accumulation of NK Cells in B Cell Lymphoma

Frontiers in Immunology, 2022
Natural killer (NK) cells have been demonstrated as a promising cellular therapy as they exert potent anti-tumor immune responses. However, applications of NK cells to tumor immunotherapy, especially in the treatment of advanced hematopoietic and solid ...
Xing Tong, Xing Tong, Xing Tong, Xing Tong, Yuhua Ru, Yuhua Ru, Yuhua Ru, Jianhong Fu, Jianhong Fu, Jianhong Fu, Ying Wang, Ying Wang, Ying Wang, Jinjin Zhu, Jinjin Zhu, Jinjin Zhu, Yiyang Ding, Yiyang Ding, Yiyang Ding, Fulian Lv, Fulian Lv, Fulian Lv, Menglu Yang, Menglu Yang, Menglu Yang, Xiya Wei, Xiya Wei, Xiya Wei, Chenchen Liu, Chenchen Liu, Chenchen Liu, Xin Liu, Xin Liu, Xin Liu, Lei Lei, Lei Lei, Lei Lei, Xiaojin Wu, Xiaojin Wu, Xiaojin Wu, Lingchuan Guo, Yang Xu, Yang Xu, Yang Xu, Jie Li, Peng Wu, Huanle Gong, Huanle Gong, Huanle Gong, Jia Chen, Jia Chen, Jia Chen, Depei Wu, Depei Wu, Depei Wu   +54 more
doaj   +1 more source

FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Cell Death and Disease, 2023
Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC.
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang   +20 more
doaj   +1 more source

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source