Results 11 to 20 of about 7,198,263 (194)

Analysis of L1 Cell Adhesion Molecule and Fucosyltransferase 8 Expression in Cells After Stretch and Human EACSCC Tissue. [PDF]

J Int Adv Otol
Background: External auditory canal (EAC) squamous cell carcinoma (SCC) is classified as a rare cancer and has a poor prognosis at advanced stages. Mechanical stress has been implicated in external auditory canal squamous cell carcinoma (EACSCC), but the
Akiyama N, Yamamoto-Fukuda T, Kojima H.
europepmc   +7 more sources

FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is ...
Taniguchi, N, Ikeda, Y, N Taniguchi, Ihara, H, Y Ikeda, CX Gao, H Ihara, Gao, CX   +7 more
core   +4 more sources

Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs)

Glycoconjugate Journal, 2020
Recently, studies have shown that Fucosylation plays an important role in the invasion and metastatic process of CSLCs. Understanding the expression pattern of fucosyltransferase (FUT) genes may help to suggest better-targeted therapy strategies for ...
Khosravi, A., Jazi, M.S., Asadi, J., Sadeghzadeh, Z.   +3 more
core   +3 more sources

Fucosyltransferase 3 and 8 promote the metastatic capacity of cancer stem-like cells via CD15s and E-cadherin in esophageal cancer [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Esophageal cancer stem cells (ECSCs) have been identified as the subset of cells within esophageal squamous cell carcinoma that possess tumorigenic, invasive, and metastatic properties.
Aliakbar Rostami Abookheili, Jahanbakhsh Asadi, Ayyoob Khosravi, Ali Gorji   +3 more
doaj   +3 more sources

Fucosyltransferase 8 is Overexpressed and Influences Clinical Outcomes in Lung Adenocarcinoma Patients. [PDF]

Pathol Oncol Res, 2022
Background: Lung adenocarcinoma (LUAD), the most prevalent type of lung cancer, is often metastatic and has a poor prognosis. Recent studies have demonstrated an important role for fucosyltransferase 8 (FUT8) in carcinogenesis and cancer progression.Methods: A meta-analysis with 15 eligible datasets from Gene Expression Omnibus (GEO) was performed to ...
Liang Y, Wang T, Gao R, Jia X, Ji T, Shi P, Xue J, Yang A, Chen M, Han P.   +9 more
europepmc   +4 more sources

Structural basis of substrate recognition and catalysis by fucosyltransferase 8. [PDF]

J Biol Chem, 2020
Abstract Fucosylation of the inner-most N-acetyl-glucosamine (GlcNAc) of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can have a dramatic impact on the activity and half-life of glycoproteins.
Järvå MA, Dramicanin M, Lingford JP, Mao R, John A, Jarman KE, Grinter R, Goddard-Borger ED.   +7 more
europepmc   +4 more sources

Fucosyltransferase 8 regulation and breast cancer suppression by transcription factor activator protein 2γ. [PDF]

Cancer Sci, 2021
AbstractAlterations of glycosyltransferase expression are often associated with tumor occurrence and progression. Among the many glycosyltransferases, increased expression of fucosyltransferase 8 (FUT8) has been frequently observed to be involved in progression and metastasis of various types of cancer.
Ma M, Guo D, Tan Z, Du J, Guan F, Li X.
europepmc   +4 more sources

A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation. [PDF]

AIDS, 2023
Objectives: Core fucosylation by fucosyltransferase 8 (FUT8) is an important posttranslational modification that impacts components of the immune system. Genetic variations in FUT8 can alter its function and could, therefore, play a role in the antiviral immune response and pathogenesis of HIV-1.
van Pul L, Maurer I, Boeser-Nunnink BDM, Harskamp AM, van Dort KA, Kootstra NA.   +5 more
europepmc   +4 more sources

O-Fucosyltransferase SPINDLY attenuates auxin-induced fruit growth by inhibiting ARF6/8-coactivator mediator complex interaction in Arabidopsis

Nature Communications
The phytohormone auxin plays a pivotal role in promoting fruit initiation and growth upon fertilization in flowering plants. Upregulation of auxin signaling by genetic mutations or exogenous auxin treatment can induce seedless fruit formation from ...
Yan Wang, Seamus Kelley, Rodolfo Zentella, Jianhong Hu, Hua Wei, Lei Wang, Jeffrey Shabanowitz, Donald F. Hunt, Tai-ping Sun   +8 more
doaj   +3 more sources

FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer [PDF]

, 2021
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation.
Jennifer Munkley, David J. Elliott, Kayla Bastian, Emma Scott   +3 more
core   +6 more sources