Results 11 to 20 of about 74,907,945 (195)

Analysis of L1 Cell Adhesion Molecule and Fucosyltransferase 8 Expression in Cells After Stretch and Human EACSCC Tissue [PDF]

The Journal of International Advanced Otology
BACKGROUND: External auditory canal (EAC) squamous cell carcinoma (SCC) is classified as a rare cancer and has a poor prognosis at advanced stages. Mechanical stress has been implicated in external auditory canal squamous cell carcinoma (EACSCC), but the molecular mechanism has not been elucidated.
Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Hiromi Kojima   +2 more
europepmc   +7 more sources

Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells. [PDF]

PLoS ONE, 2016
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. The α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed
Yutaka Okagawa, Kohichi Takada, Yohei Arihara, Shohei Kikuchi, Takahiro Osuga, Hajime Nakamura, Yusuke Kamihara, Naotaka Hayasaka, Makoto Usami, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato   +12 more
doaj   +3 more sources

FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ihara, H, Gao, CX, Ikeda, Y, Taniguchi, N   +3 more
openaire   +4 more sources

Fucosyltransferase 8 regulation and breast cancer suppression by transcription factor activator protein 2γ [PDF]

Cancer Science, 2021
AbstractAlterations of glycosyltransferase expression are often associated with tumor occurrence and progression. Among the many glycosyltransferases, increased expression of fucosyltransferase 8 (FUT8) has been frequently observed to be involved in progression and metastasis of various types of cancer.
Minxing Ma, Dong Guo, Zengqi Tan, Jun Du, Feng Guan, Xiang Li   +5 more
openaire   +3 more sources

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer [PDF]

Proceedings of the National Academy of Sciences, 2012
The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1,6-fucosylation in mammals, has been observed in several malignant cancers including liver, ovarian, thyroid, and colorectal cancers. However, the pathological role and the regulatory mechanism of FUT8 in cancers remain largely unknown.
Chien-Yu, Chen, Yi-Hua, Jan, Yi-Hsiu, Juan, Chih-Jen, Yang, Ming-Shyan, Huang, Chong-Jen, Yu, Pan-Chyr, Yang, Michael, Hsiao, Tsui-Ling, Hsu, Chi-Huey, Wong   +9 more
openaire   +3 more sources

A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation [PDF]

AIDS, 2023
Objectives: Core fucosylation by fucosyltransferase 8 (FUT8) is an important posttranslational modification that impacts components of the immune system. Genetic variations in FUT8 can alter its function and could, therefore, play a role in the antiviral immune response and pathogenesis of HIV-1.
van Pul, Lisa, Maurer, Irma, Boeser-Nunnink, Brigitte D. M., Harskamp, Agnes M., van Dort, Karel A., Kootstra, Neeltje A.   +5 more
openaire   +4 more sources

Fucosyltransferase 8 deficiency suppresses breast cancer cell migration by interference of the FAK/integrin pathway [PDF]

Cancer Biomarkers, 2019
BACKGROUND AND OBJECTIVE: Fucosyltranferase 8 (FUT8), which catalyzes core fucosylation of glycopeptides, plays important roles in cancer development. In this study, we aimed to explore the influence of FUT8 expression on migration ability of human breast cancer cells and its potential mechanisms.
Liu, Deshui, Gao, Zhiying, Yue, Liling
openaire   +3 more sources

Fucosyltransferase 8‐Derived Circular RNA Drives M2 Polarization of Macrophages Through ENO1‐TNF Signaling Axis to Promote Lung Cancer Progression [PDF]

Thoracic Cancer
Background Lung cancer, representing a predominant form of pulmonary malignancy, demonstrates significant disease burden and poor clinical outcomes. Circular RNAs (circRNAs) have emerged as critical regulators in various cancers, including lung cancer ...
Yang Ren, Yidan Shen, Qingguo Wu, Peng Zhang, Lei Wang, Feng Li, Yinzhong Shen   +6 more
doaj   +2 more sources

POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma. [PDF]

Brain Behav
ABSTRACT Objective Protein O‐fucosyltransferase 1 (POFUT1) has been implicated in several malignancies, but its functional and prognostic significance in glioma remains insufficiently defined. This study evaluated whether POFUT1 expression is associated with glioma progression, patient outcome, and PI3K/AKT pathway activity.
Yang K, Ju C, Wang Y, Guo A, Yang X, Mi Y, Su Y, Wang C, Ji H.   +8 more
europepmc   +2 more sources

Fucosyltransferase 8 expression in breast cancer patients: A high throughput tissue microarray analysis. [PDF]

Histology and histopathology, 2016
The aim of this study was to compare the expression of fucosyltransferase 8 (FUT8) in breast cancer tissue and to investigate the relationship between this marker with tumor progression and its applicability to differential diagnosis. An immunohistochemical study was performed for FUT8 using the tissue microarray technique.
Yue, Liling, Han, Cuicui, Li, Zubin, Li, Xin, Liu, Deshui, Liu, Shulin, Yu, Haitao   +6 more
openaire   +4 more sources