Results 41 to 50 of about 74,907,945 (195)
The Dual Role and Clinical Potential of Core Fucosylation in Liver Diseases
Shengwu huaxue yu shengwu wuli jinzhanCore fucosylation, catalyzed exclusively by fucosyltransferase 8 (FUT8), is an evolutionarily conserved post-translational modification that has emerged as a central regulatory hub linking liver homeostasis, chronic disease progression, and malignant ...
LEI Zi-Han +4 more
doaj +1 more source
Cytogenetics, conserved synteny and evolution of chicken fucosyltransferase genes compared to human
, 2003 Fucosyltransferases appeared early in evolution, since they are present from bacteria to primates and the genes are well conserved. The aim of this work was to study these genes in the bird group, which is particularly attractive for the comprehension of
Zoorob, R. +9 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu +7 more
wiley +1 more source
Modulation of Animal Gut Health by Milk Oligosaccharide
Animal Research and One Health, EarlyView.This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source
Purification and Some Properties of Fucosyltransferase in Human Parotid Saliva
, 1987 Fucosyltransferase was purified from human parotid saliva by affinity chromatography on GDP-hexanolamine Sepharose, followed by chromatofocusing on PBE 94 exchanger gel. The purified enzyme had the N-acetylglucosaminide α1→4, the N-acetylglucosaminide α1→
T. Takeshita +5 more
core +1 more source
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function. [PDF]
PLoS ONE, 2014 Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in Drosophila) is pivotal for NOTCH function.
Julia Müller +5 more
doaj +1 more source
Pathogens, 2021 Helicobacter pylori (H. pylori) adhesion to human gastric epithelial cells is closely linked with fucosylated glycans. Therefore, investigation of fucosylation in the interaction of gastric epithelial cells with H. pylori is critical.
Ruyue Fan +12 more
doaj +1 more source
Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease
Arthritis &Rheumatology, EarlyView.Objective Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of patients at high risk of developing lymphoma are lacking.
Hanna Lidberg +2 more
wiley +1 more source
Structure-based prioritization of marine natural products as candidate FUT8 binders
In Silico Research in BiomedicineProtein glycosylation is one of the most common post-translational modifications and plays an important role in maintaining protein structure and function. Aberrant glycosylation can alter the structural profile of glycoproteins in colorectal cancer (CRC)
Khandu Wadhonkar +3 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source