Results 51 to 60 of about 7,198,263 (194)

Separation of Fucosyltransferase and Endogenous Acceptors of Fucose from Human Parotid Saliva [PDF]

, 1977
Using gel filtration on Sephadex G-100 and column chromatography on CM-cellulose, fractions containing either endogenous acceptor of L-fucose or fucosyltransferase were obtained from human parotid saliva.
Iwasaki, E., Nakamura, R., Shibata, S., S. Shizukuishi, E. Iwasaki, Tsunemitsu, A., T. Taniguchi, Shizukuishi, S., Taniguchi, T., R. Nakamura, S. Shibata, A. Tsunemitsu   +11 more
core   +1 more source

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors

Cancer Medicine
Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis ...
Kayla Bastian, Margarita Orozco‐Moreno, Huw Thomas, Kirsty Hodgson, Eline A. Visser, Emiel Rossing, Johan F. A. Pijnenborg, Nienke Eerden, Laura Wilson, Hasvini Saravannan, Oliver Hanley, Grace Grimsley, Fiona Frame, Ziqian Peng, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Norman J. Maitland, Rakesh Heer, Ning Wang, Ethan D. Goddard‐Borger, Ramon Hurtado Guerrero, Thomas J. Boltje, Richard R. Drake, Emma Scott, David J. Elliott, Jennifer Munkley   +28 more
doaj   +1 more source

Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota

Frontiers in Microbiology, 2020
The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao, Qingjie Fan, Yaqiang Bai, Hui Fang, Jiaorui Zhou, Tomohiko Fukuda, Jianguo Gu, Ming Li, Wenzhe Li   +8 more
doaj   +1 more source

Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease

BMC Immunology, 2023
Inflammatory bowel disease (IBD) is a common immune-mediated condition with its molecular pathogenesis remaining to be fully elucidated. This study aimed to deepen our understanding of the role of FUT2 in human IBD, by studying a new surrogate gene Sec1,
Jing Cai, Hao Wu, Chenxing Wang, Yujiao Chen, Dingli Zhang, Shiwei Guan, Beilei Fu, Yingli Jin, Cao Qian   +8 more
doaj   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Core fucosylation regulates the ovarian response via FSH receptor during follicular development

Journal of Advanced Research
Introduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li   +9 more
doaj   +1 more source

Decreased core-fucosylation contributes to malignancy in gastric cancer. [PDF]

PLoS ONE, 2014
The object of the study is to identify N-glycan profiling changes associated with gastric cancer and explore the impact of core-fucosylation on biological behaviors of human gastric cancer cells.
Yun-Peng Zhao, Xin-Yun Xu, Meng Fang, Hao Wang, Qing You, Chang-Hong Yi, Jun Ji, Xing Gu, Ping-Ting Zhou, Cheng Cheng, Chun-Fang Gao   +10 more
doaj   +1 more source

Harnessing exotic germplasm for red clover improvement: Tracking genomic introgression and deploying genomic selection

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Red clover (Trifolium pratense L.) is a globally important temperate forage legume. Its symbiosis with soil‐borne rhizobia enables nitrogen fixation, and its ability to produce quality forage under diverse soil conditions enhances pasture productivity, particularly during water deficits.
A. D. Heslop, S. K. Arojju, R. W. Hofmann, J. L. Ford, C. A. Hefer, M. Z. Z. Jahufer, A. C. Larking, W. Hong, T. P. Bilton, R. Ashby, J. O'Connor, A. G. Griffiths   +11 more
wiley   +1 more source

FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins

Stem Cell Reports, 2018
Summary: Since hundreds of clinical trials are investigating the use of multipotent stromal cells (MSCs) for therapeutic purposes, effective delivery of the cells to target tissues is critical.
Baarkullah Awan, David Turkov, Cameron Schumacher, Antonio Jacobo, Amber McEnerney, Ashley Ramsey, Gege Xu, Dayoung Park, Stefanos Kalomoiris, Wei Yao, Li-En Jao, Miguel L. Allende, Carlito B. Lebrilla, Fernando A. Fierro   +13 more
doaj   +1 more source