Results 61 to 70 of about 74,907,945 (195)

RETRACTED ARTICLE: MiR-200c/FUT4 axis prevents the proliferation of colon cancer cells by downregulating the Wnt/β-catenin pathway

BMC Cancer, 2021
Background MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of
Jinchun Cong, Jian Gong, Chuanjia Yang, Zhixiu Xia, Hong Zhang   +4 more
doaj   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, Volume 36, Issue 78, 28 September 2026.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors

Cancer Medicine
Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis ...
Kayla Bastian, Margarita Orozco‐Moreno, Huw Thomas, Kirsty Hodgson, Eline A. Visser, Emiel Rossing, Johan F. A. Pijnenborg, Nienke Eerden, Laura Wilson, Hasvini Saravannan, Oliver Hanley, Grace Grimsley, Fiona Frame, Ziqian Peng, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Norman J. Maitland, Rakesh Heer, Ning Wang, Ethan D. Goddard‐Borger, Ramon Hurtado Guerrero, Thomas J. Boltje, Richard R. Drake, Emma Scott, David J. Elliott, Jennifer Munkley   +28 more
doaj   +1 more source

Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota

Frontiers in Microbiology, 2020
The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao, Qingjie Fan, Yaqiang Bai, Hui Fang, Jiaorui Zhou, Tomohiko Fukuda, Jianguo Gu, Ming Li, Wenzhe Li   +8 more
doaj   +1 more source

Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease

BMC Immunology, 2023
Inflammatory bowel disease (IBD) is a common immune-mediated condition with its molecular pathogenesis remaining to be fully elucidated. This study aimed to deepen our understanding of the role of FUT2 in human IBD, by studying a new surrogate gene Sec1,
Jing Cai, Hao Wu, Chenxing Wang, Yujiao Chen, Dingli Zhang, Shiwei Guan, Beilei Fu, Yingli Jin, Cao Qian   +8 more
doaj   +1 more source

CircFut8 Suppresses Bladder Cancer by Modulating SRSF9‐Dependent Pre‐mRNA Splicing

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
This schematic illustrates the mechanism by which circFut8 suppresses bladder cancer progression. Under high circFut8 levels, circFut8 competitively binds the splicing factor SRSF9, reducing SRSF9's association with FUT8 pre‐mRNA. This promotes exon 3 skipping, leading to increased production of the FUT8‐4 splice variant, which correlates with reduced ...
Weifeng Yang, Lv Yao, Lijun Wan, Changshui Zhuang   +3 more
wiley   +1 more source

The Cytoplasmic Tail of α1,2-Fucosyltransferase Contains a Sequence for Golgi Localization

, 2001
C1 - Journal Articles RefereedThe Golgi apparatus has a central role in the glycosylation of proteins and lipids. There is a sequential addition of carbohydrates by glycosyltransferases that are distributed within the Golgi in the order in which the ...
Taylor, SG, Milland, J, Sandrin, MS, Dodson, HC, McKenzie, IFC   +4 more
core   +1 more source

Core fucosylation regulates the ovarian response via FSH receptor during follicular development

Journal of Advanced Research
Introduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li   +9 more
doaj   +1 more source

Decreased core-fucosylation contributes to malignancy in gastric cancer. [PDF]

PLoS ONE, 2014
The object of the study is to identify N-glycan profiling changes associated with gastric cancer and explore the impact of core-fucosylation on biological behaviors of human gastric cancer cells.
Yun-Peng Zhao, Xin-Yun Xu, Meng Fang, Hao Wang, Qing You, Chang-Hong Yi, Jun Ji, Xing Gu, Ping-Ting Zhou, Cheng Cheng, Chun-Fang Gao   +10 more
doaj   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source