Results 71 to 80 of about 74,907,945 (195)

FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins

Stem Cell Reports, 2018
Summary: Since hundreds of clinical trials are investigating the use of multipotent stromal cells (MSCs) for therapeutic purposes, effective delivery of the cells to target tissues is critical.
Baarkullah Awan, David Turkov, Cameron Schumacher, Antonio Jacobo, Amber McEnerney, Ashley Ramsey, Gege Xu, Dayoung Park, Stefanos Kalomoiris, Wei Yao, Li-En Jao, Miguel L. Allende, Carlito B. Lebrilla, Fernando A. Fierro   +13 more
doaj   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Harnessing exotic germplasm for red clover improvement: Tracking genomic introgression and deploying genomic selection

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Red clover (Trifolium pratense L.) is a globally important temperate forage legume. Its symbiosis with soil‐borne rhizobia enables nitrogen fixation, and its ability to produce quality forage under diverse soil conditions enhances pasture productivity, particularly during water deficits.
A. D. Heslop, S. K. Arojju, R. W. Hofmann, J. L. Ford, C. A. Hefer, M. Z. Z. Jahufer, A. C. Larking, W. Hong, T. P. Bilton, R. Ashby, J. O'Connor, A. G. Griffiths   +11 more
wiley   +1 more source

Antitumor activity of chLpMab‐2, a human–mouse chimeric cancer‐specific antihuman podoplanin antibody, via antibody‐dependent cellular cytotoxicity

Cancer Medicine, 2017
Human podoplanin (hPDPN), a platelet aggregation‐inducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to C‐type lectin‐like receptor 2 (CLEC‐2).
Mika K. Kaneko, Shinji Yamada, Takuro Nakamura, Shinji Abe, Yasuhiko Nishioka, Akiko Kunita, Masashi Fukayama, Yuki Fujii, Satoshi Ogasawara, Yukinari Kato   +9 more
doaj   +1 more source

In vivo activity of recombinant human Lewis fucosyltransferase III in leaves of Nicotiana tabacum

, 2008
International audienceFucosylation in plants occurs in glycoproteins and polysaccharides but the function of fucosylation is largely unknown. We aimed to analyze the effects of over-expression of human fucosyltransferase III (hFucT III) on in vivo N ...
Labrousse, Pascal, Léonard, R., Costa, Guy, P. Labrousse, Lhernould, Sabine, S. Lhernould, D. Lejolly, Lejolly, D., M. Carlué, R. Léonard, G. Costa, Carlué, M.   +11 more
core   +1 more source

Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.

PLoS Genetics, 2014
Metabolic traits are molecular phenotypes that can drive clinical phenotypes and may predict disease progression. Here, we report results from a metabolome- and genome-wide association study on (1)H-NMR urine metabolic profiles.
Rico Rueedi, Mirko Ledda, Andrew W Nicholls, Reza M Salek, Pedro Marques-Vidal, Edgard Morya, Koichi Sameshima, Ivan Montoliu, Laeticia Da Silva, Sebastiano Collino, François-Pierre Martin, Serge Rezzi, Christoph Steinbeck, Dawn M Waterworth, Gérard Waeber, Peter Vollenweider, Jacques S Beckmann, Johannes Le Coutre, Vincent Mooser, Sven Bergmann, Ulrich K Genick, Zoltán Kutalik   +21 more
doaj   +1 more source

O-Glycosylation of thrombospondin type 1 repeats : identification and characterisation of β1,3-glucosyltransferase [PDF]

, 2008
Rare types of protein glycosylation often occur in a domain-specific manner required for important biological functions (Okajima et al. 2008). O-linked fucosylation, where the fucose is linked directly to the hydroxyl groups of serine or threonine ...
Keusch, Krisztina
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9

, 2023
Mammalian cell surface and secreted glycoproteins exhibit remarkable glycan structural diversity that contributes to numerous physiological and pathogenic interactions. Terminal glycan structures include Lewis antigens synthesized by a collection of α1,3/
Wang, Shuo, Prudden, Anthony R., Moremen, Kelley W., Chapla, Digantkumar, Ramiah, Annapoorani, Hudson, Kieran L., Withers, Stephen G., Huang, Chin, Kadirvelraj, Renuka, Boruah, Bhargavi M., Boons, Geert-Jan, Wood, Zachary A.   +11 more
core  

Xyloglucan fucosyltransferase, an enzyme involved in plant cell wall biosynthesis [PDF]

, 1999
Cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins.
Zeng, Weiqing, Norambuena Morales, Lorena, Raikhel, Natasha V., Keegstra, Kenneth, Orellana, Ariel, DeRocher, Amy E., Bar-Peled, Maor, Perrin, Robyn M.   +7 more
core   +1 more source