Results 81 to 90 of about 74,907,945 (195)

Core fucosylation of IL-2RB is required for natural killer cell homeostasis

Cell Reports
Summary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz, Xiangpeng Meng, Hae-Young Park, Zihan Shen, Iva Nikolic, Joseph Cursons, Ethan D. Goddard-Borger, Iona S. Schuster, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Nichollas E. Scott, Michael Chopin, Jai Rautela, Sebastian Scheer, Nicholas D. Huntington   +14 more
doaj   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

Synthetic Retinoid Sulfarotene Selectively Inhibits Tumor‐Repopulating Cells of Intrahepatic Cholangiocarcinoma via Disrupting Cytoskeleton by P‐Selectin/PSGL1 N‐Glycosylation Blockage

Advanced Science
Intrahepatic cholangiocarcinoma (ICC) is a highly lethal malignancy that currently lacks effective clinical treatments. Eliminating stem cell‐like cancer cells is an extremely promising but challenging strategy for treating ICC.
Xiaojing Du, Zhuoran Qi, Sinuo Chen, Jinlan Wu, Ye Xu, Sunkuan Hu, Zhijie Yu, Jiayun Hou, Yuan Fang, Jinglin Xia, Xin Cao   +10 more
doaj   +1 more source

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer.

PLoS ONE, 2018
The expression of fucosyltransferase 8, an enzyme responsible for core fucosylation encoded by FUT8, influences tumor biology and correlates with patient prognosis in several solid cancers.
Masaru Noda, Hirokazu Okayama, Yasuhide Kofunato, Shun Chida, Katsuharu Saito, Takeshi Tada, Mai Ashizawa, Takahiro Nakajima, Keita Aoto, Tomohiro Kikuchi, Wataru Sakamoto, Hisahito Endo, Shotaro Fujita, Motonobu Saito, Tomoyuki Momma, Shinji Ohki, Koji Kono   +16 more
doaj   +1 more source

FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression

Cell Death Discovery
Clear cell renal cell carcinoma (ccRCC) is characterized by the loss of the von Hippel–Lindau (VHL) gene, leading to constitutive activation of hypoxia-inducible transcription factors (HIFs) and metabolic reprogramming toward aerobic glycolysis. Although
Zikai Guo, Hongxiao Jiang, Xu Wang, Ke Xuan, Huidong Zhong, Chengxi Liu, Mengkai Zhang, Zhichao Li, Weiren Huang, Yangyang Sun   +9 more
doaj   +1 more source

Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l-Fucose Metabolism of Gut Bifidobacterium spp. and Lactobacillus spp

mBio, 2019
The maternal milk glycobiome is crucial for shaping the gut microbiota of infants. Although high core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is a general feature of human milk glycoproteins, its role in the formation of a healthy ...
Ming Li, Yaqiang Bai, Jiaorui Zhou, Wei Huang, Jingyu Yan, Jia Tao, Qingjie Fan, Yang Liu, Di Mei, Qiulong Yan, Jieli Yuan, Patrice Malard, Zhongfu Wang, Jianguo Gu, Naoyuki Tanigchi, Wenzhe Li   +15 more
doaj   +1 more source

Co-purification of the Lewis Blood group N-acetylglucosaminide α1→4 fucosyltransferase and an N-acetylglucosaminide α1→3 fucosyltransferase from human milk

, 1981
The Lewis blood group-specified N-acetylglucosaminide α1 →4 fucosyltransferase and an N-acetylglucosaminide α1 →3 fucosyltransferase have been co-purified over 500,000-fold from human milk by affinity chromatography on GDP-hexanolamine agarose.
Monnom, Dominique, Dolmans, Marcel, Prieels, Jean-Paul, Beyer, Thomas A., Hill, Robert R.L.   +4 more
core  

Differentiative changes in fucosyltransferase activity in newborn rat epidermal cells [PDF]

, 1992
An enzymatic activity catalyzing the transfer of L-fucose from GDP-L-fucose to a glycoprotein that is associated with the surfaces of the basal cells has been found in the membranous fraction of the cutaneous epidermis from the newborn rat.
Xiang, Jianming, Bernstein, Isadore A.
core   +1 more source

sj-jpg-1-onc-10.1177_11795549231181189 – for Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles

, 2023
sj-jpg-1-onc-10.1177_11795549231181189 for Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles by Jingheng Guo, Qian Cheng, Yongjian Li, Lingyu ...
Qian Cheng (285039), Lingyu Tian (9145101), Zhao Li (300229), Delin Ma (3772633), Jie Gao (10266), Jingheng Guo (16491817), Jiye Zhu (697006), Yongjian Li (843885)   +7 more
core   +1 more source

Substrate Specificity Study of α1,3-Fucosyltransferase from Helicobacter pylori

, 2007
Helicobacter pylori is a major gastroduodenal pathogen to cause gastric and duodenal ulcers. The infection is associated with atrophic gastritis, a precondition to gastric cancer and lymphoma.
Wu, I-Lin, 吳易霖
core