Results 21 to 30 of about 4,088 (175)

FUT8 Promotes Melanoma Invasion and Metastasis

Cancer Discovery, 2017
FUT8-mediated core fucosylation of L1CAM drives melanoma metastasis.

core   +2 more sources

Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response.

PLoS ONE, 2023
GlycoMaple is a new tool to predict glycan structures based on the expression levels of 950 genes encoding glycan biosynthesis-related enzymes and proteins using RNA-seq data.
Yuki M Kyunai, Mika Sakamoto, Mayuko Koreishi, Yoshio Tsujino, Ayano Satoh   +4 more
doaj   +5 more sources

Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation [PDF]

The American Journal of Human Genetics, 2018
Fucosyltransferase 8 (FUT8) encodes a Golgi-localized alpha1,6 fucosyltransferase that is essential for transferring the monosaccharide fucose into N-linked glycoproteins, a process known as core fucosylation.
Bobby G. Ng, Hudson H. Freeze, Raymond, Kimiyo, Ng, Bobby G., David F. Kronn, Nandini Chandy, Joan Steyermark, Ali AlAsmari, AlAsmari, Ali, Faqeih, Eissa Ali, Kronn, David F, Berry, Susan A, Ng, Bobby G, Lebrilla, Carlito B., Kimiyo Raymond, Radtke, Kelly, Freeze, Hudson H., Kronn, David, Carlito B. Lebrilla, Powis, Zoe, Shinde, Deepali N., Eissa Ali Faqeih, Gege Xu, Sharon F. Suchy, Shinde, Deepali N, Kelly Radtke, Berry, Susan A., Lebrilla, Carlito B, Steyermark, Joan, Deepali N. Shinde, Susan A. Berry, Suchy, Sharon F, Xu, Gege, Zöe Powis, Freeze, Hudson H, Suchy, Sharon F., Chandy, Nandini   +36 more
core   +6 more sources

FUT8: AN EMERGING DRIVER OF METASTASIS [PDF]

Pakistan Journal of Medicine and Dentistry
This critical research periodical is mainly based on critical review of research article titled “A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis” published in Cancer Cell by Agrawal et al1. Glycosylation is the distinct cell
Zil-e-Rubab PJMD, Hussain Shah
core   +3 more sources

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion [PDF]

Advanced Science
Glycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
doaj   +2 more sources

The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation [PDF]

Journal of Biological Chemistry, 2020
Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins. However, how FUT8 activity is regulated in cells remains largely unclear.
Seita Tomida, Misaki Takata, Tetsuya Hirata, Masamichi Nagae, Miyako Nakano, Yasuhiko Kizuka   +5 more
openaire   +2 more sources

Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts [PDF]

PeerJ, 2021
Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Zhiming Wu, Tianye Lin, Pan Kang, Zhikun Zhuang, Haibin Wang, Wei He, Qiushi Wei, Ziqi Li   +7 more
doaj   +2 more sources

FUT8-AS1 Inhibits the Malignancy of Melanoma Through Promoting miR-145-5p Biogenesis and Suppressing NRAS/MAPK Signaling

Frontiers in Oncology, 2021
Melanoma is the major lethal skin malignancy. However, the critical molecular drivers governing melanoma progression and prognosis are still not clear. By analyzing The Cancer Genome Atlas (TCGA) data, we identified FUT8-AS1 as a prognosis-related long ...
Xiang-jun Chen, Sha Liu, Dong-mei Han, De-zhi Han, Wei-jing Sun, Xiao-chun Zhao, Jun-qing Liang, Li Yu   +7 more
doaj   +1 more source

Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice

Journal of Microbiology, Immunology and Infection, 2021
Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses ...
Danish Zahid, Nianzhu Zhang, Hui Fang, Jianguo Gu, Ming Li, Wenzhe Li   +5 more
doaj   +1 more source

FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment [PDF]

Journal of Cancer, 2021
Glycosylation changes are key molecular events in tumorigenesis, progression and glycosyltransferases play a vital role in the this process. FUT8 belongs to the fucosyltransferase family and is the key enzyme involved in N-glycan core fucosylation. FUT8 and/or core fucosylated proteins are frequently upregulated in liver, lung, colorectal, pancreas ...
Liao, Chengcheng, An, Jiaxing, Yi, Suqin, Tan, Zhangxue, Wang, Hui, Li, Hao, Guan, Xiaoyan, Liu, Jianguo, Wang, Qian   +8 more
openaire   +2 more sources