Results 21 to 30 of about 616 (125)

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer.

PLoS ONE, 2018
The expression of fucosyltransferase 8, an enzyme responsible for core fucosylation encoded by FUT8, influences tumor biology and correlates with patient prognosis in several solid cancers.
Masaru Noda, Hirokazu Okayama, Yasuhide Kofunato, Shun Chida, Katsuharu Saito, Takeshi Tada, Mai Ashizawa, Takahiro Nakajima, Keita Aoto, Tomohiro Kikuchi, Wataru Sakamoto, Hisahito Endo, Shotaro Fujita, Motonobu Saito, Tomoyuki Momma, Shinji Ohki, Koji Kono   +16 more
doaj   +2 more sources

Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma.

PLoS ONE
Lung cancer remains the leading cause of malignant tumors worldwide in terms of the incidence and mortality, posing a significant threat to human health.
Zhijun Li, Zhenpeng Zhu, Peng Wang, Chenyang Hou, Lijuan Ren, Dandan Xu, Xiran Wang, Fei Guo, Qingxue Meng, Weizheng Liang, Jun Xue, Xuejun Zhi   +11 more
doaj   +2 more sources

The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation [PDF]

Journal of Biological Chemistry, 2020
Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins. However, how FUT8 activity is regulated in cells remains largely unclear.
Seita Tomida, Misaki Takata, Tetsuya Hirata, Masamichi Nagae, Miyako Nakano, Yasuhiko Kizuka   +5 more
openaire   +2 more sources

FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment [PDF]

Journal of Cancer, 2021
Glycosylation changes are key molecular events in tumorigenesis, progression and glycosyltransferases play a vital role in the this process. FUT8 belongs to the fucosyltransferase family and is the key enzyme involved in N-glycan core fucosylation. FUT8 and/or core fucosylated proteins are frequently upregulated in liver, lung, colorectal, pancreas ...
Liao, Chengcheng, An, Jiaxing, Yi, Suqin, Tan, Zhangxue, Wang, Hui, Li, Hao, Guan, Xiaoyan, Liu, Jianguo, Wang, Qian   +8 more
openaire   +2 more sources

Crystal structure of mammalian α1,6-fucosyltransferase, FUT8 [PDF]

Glycobiology, 2006
Mammalian alpha1,6-fucosyltransferase (FUT8) catalyses the transfer of a fucose residue from a donor substrate, guanosine 5'-diphosphate-beta-L-fucose to the reducing terminal N-acetylglucosamine (GlcNAc) of the core structure of an asparagine-linked oligosaccharide.
Hideyuki, Ihara, Yoshitaka, Ikeda, Sachiko, Toma, Xiangchun, Wang, Tadashi, Suzuki, Jianguo, Gu, Eiji, Miyoshi, Tomitake, Tsukihara, Koichi, Honke, Akio, Matsumoto, Atsushi, Nakagawa, Naoyuki, Taniguchi   +11 more
openaire   +2 more sources

Evaluating epilepsy and refractory epilepsy by Fut8.

, 2023
Evaluating epilepsy and refractory epilepsy by Fut8.
Zhou Zhang (197948), Yunxiu Huang (15285530), Linmu Chen (14439559)   +2 more
core   +1 more source

The stem region of α1,6-fucosyltransferase FUT8 is required for multimer formation but not catalytic activity

, 2022
Alpha-1,6-fucosyltransferase (FUT8) synthesizes core fucose in N-glycans, which plays critical roles in various physiological processes. FUT8, as with many other glycosyltransferases, is a type-II membrane protein, and its large C-terminal catalytic ...
Kizuka, Yasuhiko, Tomida, Seita, Nagae, Masamichi   +2 more
core   +1 more source

Correlation between serum Fut8 expression and valproic acid concentration.

, 2023
A. The expression of Fut8 in three groups were detected by ELISA. B. Pearson Correlation analyzed the correlation between Fut8 and valproic acid in epilepsy patients. C.
Zhou Zhang (197948), Yunxiu Huang (15285530), Linmu Chen (14439559)   +2 more
core   +1 more source

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer

Biochemistry and Biophysics Reports, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Hana Shimoyama, Toshiaki K. Shibata, Masahiko Ito, Tomoaki Oda, Toshiya Itoh, Mari Mukai, Madoka Matsuya-Ogawa, Masashi Adachi, Hirotake Murakami, Takeshi Nakayama, Kazuhiro Sugihara, Hiroaki Itoh, Tetsuro Suzuki, Naohiro Kanayama   +13 more
doaj   +1 more source

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source