Results 11 to 20 of about 616 (125)

The α1,6-fucosyltransferase gene (fut8) from the Sf9 lepidopteran insect cell line: insights into fut8 evolution.

PLoS ONE, 2014
The core alpha1,6-fucosyltransferase (FUT8) catalyzes the transfer of a fucosyl moiety from GDP-fucose to the innermost asparagine-linked N-acetylglucosamine residue of glycoproteins.
Sylvie Juliant, Anne Harduin-Lepers, François Monjaret, Béatrice Catieau, Marie-Luce Violet, Pierre Cérutti, Annick Ozil, Martine Duonor-Cérutti   +7 more
doaj   +6 more sources

Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis

Cell & Bioscience, 2023
Background Atherosclerosis (AS) is the leading underlying cause of the majority of clinical cardiovascular events. Retention of foamy macrophages in plaques is the main factor initiating and promoting the atherosclerotic process. Our previous work showed
Xi Yang, Limei Ma, Jun Zhang, Linmu Chen, Zhen Zou, Di Shen, Hui He, Lei Zhang, Jun Chen, Zhiyi Yuan, Xia Qin, Chao Yu   +11 more
doaj   +4 more sources

Expanding the molecular and clinical phenotypes of FUT8‐CDG [PDF]

Journal of Inherited Metabolic Disease, 2020
AbstractPathogenic variants in the Golgi localised alpha 1,6 fucosyltransferase, FUT8, cause a rare inherited metabolic disorder known as FUT8‐CDG. To date, only three affected individuals have been reported presenting with a constellation of symptoms including intrauterine growth restriction, severe delays in growth and development, other neurological
Ng B. G., Dastsooz H., Silawi M., Habibzadeh P., Jahan S. B., Fard M. A. F., Halliday B. J., Raymond K., Ruzhnikov M. R. Z., Tabatabaei Z., Taghipour-Sheshdeh A., Brimble E., Robertson S. P., Faghihi M. A., Freeze H. H.   +14 more
openaire   +5 more sources

Development of a FUT8 Inhibitor with Cellular Inhibitory Properties [PDF]

Angewandte Chemie International Edition
Abstract Core fucosylation is catalyzed by α‐1,6‐fucosyltransferase (FUT8), which fucosylates the innermost GlcNAc of N ‐glycans. Given the association of FUT8 with various diseases, including cancer, selective FUT8 inhibitors applicable to in vivo or cell‐based systems are ...
Yoshiyuki Manabe, Tomoyuki Takebe, Satomi Kasahara, Koki Hizume, Kazuya Kabayama, Yoshihiro Kamada, Akiko Asakura, Shinichiro Shinzaki, Shinji Takamatsu, Eiji Miyoshi, Ana García‐García, Sergey Y. Vakhrushev, Ramón Hurtado‐Guerrero, Koichi Fukase   +13 more
core   +10 more sources

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors [PDF]

Cancer Medicine
Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis ...
Kayla Bastian, Margarita Orozco‐Moreno, Huw Thomas, Kirsty Hodgson, Eline A. Visser, Emiel Rossing, Johan F. A. Pijnenborg, Nienke Eerden, Laura Wilson, Hasvini Saravannan, Oliver Hanley, Grace Grimsley, Fiona Frame, Ziqian Peng, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Norman J. Maitland, Rakesh Heer, Ning Wang, Ethan D. Goddard‐Borger, Ramon Hurtado Guerrero, Thomas J. Boltje, Richard R. Drake, Emma Scott, David J. Elliott, Jennifer Munkley   +28 more
doaj   +7 more sources

FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ihara, H, Gao, CX, Ikeda, Y, Taniguchi, N   +3 more
openaire   +4 more sources

Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation [PDF]

The American Journal of Human Genetics, 2018
Fucosyltransferase 8 (FUT8) encodes a Golgi-localized α1,6 fucosyltransferase that is essential for transferring the monosaccharide fucose into N-linked glycoproteins, a process known as "core fucosylation." Here we describe three unrelated individuals, who presented with intrauterine growth retardation, severe developmental and growth delays with ...
Ng, Bobby G, Xu, Gege, Chandy, Nandini, Steyermark, Joan, Shinde, Deepali N, Radtke, Kelly, Raymond, Kimiyo, Lebrilla, Carlito B, AlAsmari, Ali, Suchy, Sharon F, Powis, Zöe, Faqeih, Eissa Ali, Berry, Susan A, Kronn, David F, Freeze, Hudson H   +14 more
openaire   +6 more sources

FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Cell Death and Disease, 2023
Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC.
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang   +20 more
doaj   +2 more sources

FUT8 Promotes Melanoma Invasion and Metastasis

Cancer Discovery, 2017
Abstract FUT8-mediated core fucosylation of L1CAM drives melanoma metastasis.
openaire   +2 more sources

Hepatitis C Virus-Induced FUT8 Causes 5-FU Drug Resistance in Human Hepatoma Huh7.5.1 Cells

Viruses, 2019
Hepatitis C virus (HCV) is a major cause of human chronic liver disease and hepatocellular carcinoma. Our recent studies showed that α1,6-fucosyltransferase (FUT8), a key glycosyltransferase, was the most up-regulated glycosyltransferase after the ...
Shu Li, Xiao-Yu Liu, Qiu Pan, Jian Wu, Zhi-Hao Liu, Yong Wang, Min Liu, Xiao-Lian Zhang   +7 more
doaj   +2 more sources