Results 11 to 20 of about 4,088 (175)

L-Fucose treatment of FUT8-CDG

Molecular Genetics and Metabolism Reports, 2020
FUT8-CDG is a severe multisystem disorder caused by mutations in FUT8, encoding the α-1,6-fucosyltransferase. We report on dizygotic twins with FUT8-CDG presenting with dysmorphisms, failure to thrive, and respiratory abnormalities.
Julien H. Park, Janine Reunert, Miao He, Robert G. Mealer, Maxence Noel, Yoshinao Wada, Marianne Grüneberg, Judit Horváth, Richard D. Cummings, Oliver Schwartz, Thorsten Marquardt   +10 more
doaj   +5 more sources

The α1,6-fucosyltransferase gene (fut8) from the Sf9 lepidopteran insect cell line: insights into fut8 evolution.

PLoS ONE, 2014
The core alpha1,6-fucosyltransferase (FUT8) catalyzes the transfer of a fucosyl moiety from GDP-fucose to the innermost asparagine-linked N-acetylglucosamine residue of glycoproteins.
Sylvie Juliant, Anne Harduin-Lepers, François Monjaret, Béatrice Catieau, Marie-Luce Violet, Pierre Cérutti, Annick Ozil, Martine Duonor-Cérutti   +7 more
doaj   +6 more sources

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +6 more sources

Diagnosis and prognosis of serum Fut8 for epilepsy and refractory epilepsy in children

PLoS ONE, 2023
With adequate serum concentration of antiepileptic drugs, the epilepsy symptoms in many patients still cannot be controlled well. The alteration of glycosyltransferase has obvious influence on the pathogenesis of epilepsy.
Yunxiu Huang, Zhou Zhang, Linmu Chen
doaj   +5 more sources

Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma. [PDF]

PLoS ONE
Lung cancer remains the leading cause of malignant tumors worldwide in terms of the incidence and mortality, posing a significant threat to human health.
Zhijun Li, Zhenpeng Zhu, Peng Wang, Chenyang Hou, Lijuan Ren, Dandan Xu, Xiran Wang, Fei Guo, Qingxue Meng, Weizheng Liang, Jun Xue, Xuejun Zhi   +11 more
doaj   +3 more sources

Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis

Cell & Bioscience, 2023
Background Atherosclerosis (AS) is the leading underlying cause of the majority of clinical cardiovascular events. Retention of foamy macrophages in plaques is the main factor initiating and promoting the atherosclerotic process. Our previous work showed
Xi Yang, Limei Ma, Jun Zhang, Linmu Chen, Zhen Zou, Di Shen, Hui He, Lei Zhang, Jun Chen, Zhiyi Yuan, Xia Qin, Chao Yu   +11 more
doaj   +4 more sources

Expanding the molecular and clinical phenotypes of FUT8‐CDG [PDF]

Journal of Inherited Metabolic Disease, 2020
Pathogenic variants in the Golgi localised alpha 1,6 fucosyltransferase, FUT8, cause a rare inherited metabolic disorder known as FUT8-CDG. To date, only three affected individuals have been reported presenting with a constellation of symptoms including ...
Bobby G. Ng, Hudson H. Freeze, Habibzadeh, Parham, Jahan, Shima B, Benjamin J. Halliday, Halliday, Benjamin J, Maura R. Z. Ruzhnikov, Mohammad A. Faghihi, Dastsooz, Hassan, Tabatabaei, Zahra, Parham Habibzadeh, Stephen P. Robertson, Taghipour-Sheshdeh, Afsaneh, Brimble, Elise, Ruzhnikov, Maura R. Z, Kimiyo Raymond, Raymond, Kimiyo, Freeze, Hudson H, Mohammad A. F. Fard, Elise Brimble, Shima B. Jahan, Faghihi, Mohammad A, Hassan Dastsooz, Afsaneh Taghipour‐Sheshdeh, Ng, Bobby G, Fard, Mohammad A. F, Robertson, Stephen P, Silawi, Mohammad, Zahra Tabatabaei, Mohammad Silawi   +29 more
core   +4 more sources

Development of a FUT8 Inhibitor with Cellular Inhibitory Properties [PDF]

Angewandte Chemie International Edition
Core fucosylation is catalyzed by α-1,6-fucosyltransferase (FUT8), which fucosylates the innermost GlcNAc of N-glycans. Given the association of FUT8 with various diseases, including cancer, selective FUT8 inhibitors applicable to in vivo or cell-based ...
Manabe, Yoshiyuki, Hurtado-Guerrero, Ramón, Kamada, Yoshihiro, Kasahara, Satomi, Vakhrushev, Sergey Y., Asakura, Akiko, Takamatsu, Shinji, Takebe, Tomoyuki, Miyoshi, Eiji, Hizume, Koki, Shinzaki, Shinichiro, García-García, Ana, Kabayama, Kazuya, Fukase, Koichi   +13 more
core   +10 more sources

Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients

Immunity, Inflammation and Disease, 2022
Background α‐1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study,
Ning Yang, Long‐kai Li, Hui He, Xia‐nan Guo, Xue‐feng Yuan, Zhi‐tong Li, Wei‐dong Wang, Biao‐jie Qin, Xiang‐ning Du, Xu Zhang, Shu‐ni Chen, Hong‐li Lin   +11 more
doaj   +2 more sources

FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is ...
Taniguchi, N, Ikeda, Y, N Taniguchi, Ihara, H, Y Ikeda, CX Gao, H Ihara, Gao, CX   +7 more
core   +4 more sources