Results 31 to 40 of about 616 (125)
Chinese Medical Journal, 2017 Background: Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor
Long-Kai Li +8 more
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Frontiers in Microbiology, 2020 The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao +8 more
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The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins [PDF]
Proceedings of the National Academy of Sciences, 2021 ABSTRACT Fucosylation of mucins, the main macrocomponents of the mucus layer that protects the digestive tract from pathogens, increases their viscoelasticity and shear stress resistance. These properties are altered in patients with ulcerative colitis (UC), which is marked by a chronic inflammation of the distal part
Gerard Cantero-Recasens +11 more
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Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response
PLOS ONE, 2022 Abstract GlycoMaple is a new tool to predict glycan structures based on the expression levels of 950 genes encoding glycan biosynthesis-related enzymes and proteins using RNA-seq data. The antioxidant response, protecting cells from oxidative stress, has been focused on because its activation may relieve pathological conditions, such as
Yuki M. Kyunai +4 more
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Thoracic Cancer, 2023 Background Lung cancer is the leading cause of cancer related to mortality worldwide, and the main pathological type is lung adenocarcinoma (LUAD). Circular RNAs (circRNAs) have been reported to be modified by N6‐methyladenosine (m6A), which is involved ...
Gaochao Dong +8 more
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Receiver operating characteristic curve for evaluating epilepsy and refractory epilepsy by Fut8.
, 2023 A. Fut8 could distinguish the epilepsy patients from healthy controls with an AUC of 0.620. B. Fut8 could distinguish the refractory epilepsy patients from healthy controls with an AUC of 0.856.
Zhou Zhang (197948) +2 more
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Brain Research BulletinAlpha-(1,6)-fucosyltransferase (FUT8) has been found to play a role in modulating the central immune system and inflammatory responses. Limited studies have assessed the correlations between serum FUT8 levels and various non-motor symptoms associated ...
Qi-rong Wang +3 more
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Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase
Nature Communications, 2020 Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García +6 more
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Breast Cancer Research, 2022 Background We recently showed that fucosyltransferase 8 (FUT8)-mediated core fucosylation of transforming growth factor-β receptor enhances its signaling and promotes breast cancer invasion and metastasis.
Cheng-Fen Tu +3 more
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α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish
Cells, 2022 Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycans.
Nozomi Hayashiji +7 more
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