Results 31 to 40 of about 4,088 (175)

Crystal structure of mammalian α1,6-fucosyltransferase, FUT8 [PDF]

Glycobiology, 2006
Mammalian alpha1,6-fucosyltransferase (FUT8) catalyses the transfer of a fucose residue from a donor substrate, guanosine 5'-diphosphate-beta-L-fucose to the reducing terminal N-acetylglucosamine (GlcNAc) of the core structure of an asparagine-linked oligosaccharide.
Hideyuki, Ihara, Yoshitaka, Ikeda, Sachiko, Toma, Xiangchun, Wang, Tadashi, Suzuki, Jianguo, Gu, Eiji, Miyoshi, Tomitake, Tsukihara, Koichi, Honke, Akio, Matsumoto, Atsushi, Nakagawa, Naoyuki, Taniguchi   +11 more
openaire   +2 more sources

Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells. [PDF]

PLoS ONE, 2016
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. The α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed
Yutaka Okagawa, Kohichi Takada, Yohei Arihara, Shohei Kikuchi, Takahiro Osuga, Hajime Nakamura, Yusuke Kamihara, Naotaka Hayasaka, Makoto Usami, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato   +12 more
doaj   +1 more source

FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

Breast Cancer Research, 2017
Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for signaling receptors involved in many physiological and pathological processes such as ...
Cheng-Fen Tu, Meng-Ying Wu, Yuh-Charn Lin, Reiji Kannagi, Ruey-Bing Yang   +4 more
doaj   +1 more source

Correlation between serum Fut8 expression and valproic acid concentration.

, 2023
A. The expression of Fut8 in three groups were detected by ELISA. B. Pearson Correlation analyzed the correlation between Fut8 and valproic acid in epilepsy patients. C.
Zhou Zhang (197948), Yunxiu Huang (15285530), Linmu Chen (14439559)   +2 more
core   +1 more source

Evaluating epilepsy and refractory epilepsy by Fut8.

, 2023
Evaluating epilepsy and refractory epilepsy by Fut8.
Zhou Zhang (197948), Yunxiu Huang (15285530), Linmu Chen (14439559)   +2 more
core   +1 more source

FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Cell Death and Disease, 2023
Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC.
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang   +20 more
doaj   +1 more source

Table3_Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation.XLSX

, 2021
The α1,6-fucosyltransferase (encoded by FUT8 gene) is the key enzyme transferring fucose to the innermost GlcNAc residue on an N-glycan through an α-1,6 linkage in the mammalian cells.
Michael J. Betenbaugh (104692), Qiong Wang (117288), Lijun Chen (313408), Ganglong Yang (778465), Hui Zhang (7197)   +4 more
core   +1 more source

The stem region of α1,6-fucosyltransferase FUT8 is required for multimer formation but not catalytic activity

, 2022
Alpha-1,6-fucosyltransferase (FUT8) synthesizes core fucose in N-glycans, which plays critical roles in various physiological processes. FUT8, as with many other glycosyltransferases, is a type-II membrane protein, and its large C-terminal catalytic ...
Kizuka, Yasuhiko, Tomida, Seita, Nagae, Masamichi   +2 more
core   +1 more source

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer

Biochemistry and Biophysics Reports, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Hana Shimoyama, Toshiaki K. Shibata, Masahiko Ito, Tomoaki Oda, Toshiya Itoh, Mari Mukai, Madoka Matsuya-Ogawa, Masashi Adachi, Hirotake Murakami, Takeshi Nakayama, Kazuhiro Sugihara, Hiroaki Itoh, Tetsuro Suzuki, Naohiro Kanayama   +13 more
doaj   +1 more source

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source