Protein Core Fucosylation Regulates Planarian Head Regeneration via Neoblast Proliferation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Protein glycosylation is an important posttranslational modification that plays a crucial role in cellular function. However, its biological roles in tissue regeneration remain interesting and primarily ambiguous.
Wenjun Wang +14 more
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Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling [PDF]
International Dental JournalBackground: Chronic inflammation in periodontitis is linked to aberrant glycosylation, yet the molecular mechanisms and therapeutic potential of the core fucosyltransferase Fut8 remain undefined.
Jiahao Lin +8 more
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Analysis of site and structure specific core fucosylation in liver cirrhosis using exoglycosidase-assisted data-independent LC-MS/MS [PDF]
Scientific Reports, 2021 Carbohydrates form one of the major groups of biological macromolecules in living organisms. Many biological processes including protein folding, stability, immune response, and receptor activation are regulated by glycosylation. Fucosylation of proteins
Miloslav Sanda +3 more
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Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression [PDF]
Renal Failure, 2021 Objective Peritoneal fibrosis (PF) ultimately causes ultrafiltration failure and peritoneal dialysis (PD) termination, but there are few effective therapies for it.
Changqing Yu +6 more
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Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation [PDF]
Frontiers in Immunology, 2018 CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Wei Liang +10 more
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EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses [PDF]
Nature CommunicationsAberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis.
Qiu Pan +6 more
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Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression [PDF]
Nature CommunicationsCore fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang +7 more
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Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion [PDF]
Advanced ScienceGlycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor ...
Yuting Cao +8 more
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Multi-targeted therapy resistance via drug-induced secretome fucosylation
eLife, 2023 Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive.
Mark Borris D Aldonza +19 more
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Advances in the study of core fucosylation in mammals
浙江大学学报. 农业与生命科学版, 2021 Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase.
TIAN Yinping, YI Wen
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