Decreased core-fucosylation contributes to malignancy in gastric cancer. [PDF]
PLoS ONE, 2014 The object of the study is to identify N-glycan profiling changes associated with gastric cancer and explore the impact of core-fucosylation on biological behaviors of human gastric cancer cells.
Yun-Peng Zhao +10 more
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Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility [PDF]
Communications Biology, 2023 Classical and accelerated molecular dynamics simulations reveal how core fucosylation in the IgG1 Fc glycan and the light chain isotype modulate the conformational behavior of the hinge and Fab domains and dynamics of IgG1 antibodies.
Simona Saporiti +11 more
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Quantitative Assessment of Core Fucosylation for Congenital Disorders of Glycosylation [PDF]
Mass SpectrometryCongenital disorders of glycosylation (CDG) include a group of diseases characterized by defects of N-glycan fucosylation. The analytical molecule of choice for the diagnosis of CDG affecting N-glycosylation is serum transferrin: approximately 10% of the glycans attached to transferrin are fucosylated via an α1,6 linkage at the innermost N ...
Yoshinao Wada
exaly +4 more sources
Core fucosylation of IL-2RB is required for natural killer cell homeostasis
Cell ReportsSummary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz +14 more
doaj +5 more sources
Advances in the study of core fucosylation in mammals
浙江大学学报. 农业与生命科学版, 2021 Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase.
TIAN Yinping, YI Wen
doaj +2 more sources
Journal of Microbiology, Immunology and Infection, 2021 Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses ...
Danish Zahid +5 more
doaj +2 more sources
Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD [PDF]
Cellular and Molecular Life Sciences, 2022 AbstractChronic obstructive pulmonary disease (COPD) is a progressive lung disease with high morbidity and mortality worldwide. Although several mechanisms to account for deleterious immune effects were proposed, molecular description for the underlying alveolar structural alterations for COPD is lacking.
Yi-Hsin Tseng, John Yu, Hsiuhui Tsai
exaly +4 more sources
Liver cancer derived high core fucosylation sEV elict malignancy by activating PI3K/AKT signaling pathway [PDF]
Cell Communication and SignalingSmall extracellular vesicles (sEV) play a key role in liver cancer (LC) by supporting cancer cell survival, local invasion, and distant metastasis.
Zhuo Li +12 more
doaj +2 more sources
Protein Core Fucosylation Regulates Planarian Head Regeneration via Neoblast Proliferation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Protein glycosylation is an important posttranslational modification that plays a crucial role in cellular function. However, its biological roles in tissue regeneration remain interesting and primarily ambiguous.
Wenjun Wang +14 more
doaj +2 more sources
Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling [PDF]
International Dental JournalBackground: Chronic inflammation in periodontitis is linked to aberrant glycosylation, yet the molecular mechanisms and therapeutic potential of the core fucosyltransferase Fut8 remain undefined.
Jiahao Lin +8 more
doaj +2 more sources