Results 61 to 70 of about 10,058 (125)

Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation

Antibodies, 2019
The biological activity of therapeutic antibodies is highly influenced by their glycosylation profile. A valuable method for increasing the cytotoxic efficacy of antibodies, which are used, for example, in cancer treatment, is the reduction of core ...
Martina Zimmermann, Janike Ehret, Harald Kolmar, Aline Zimmer   +3 more
doaj   +1 more source

FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis

npj Precision Oncology
Tumor competition for nutrients within the microenvironment triggers stress responses to adapt to adverse conditions; however, the mechanism by which a glucose-depleted environment influences tumor fucosylation to promote endoplasmic reticulum (ER ...
Kaiwen Qin, Haonan Zhang, Yulu Shi, Ruo Wu, Changjie Wu, Yihan Wu, Chengcheng He, Zelong Han, Yuchen Luo, Yuxin Fang, Xinrui Yan, Xinke Wang, Mingsong Li, Aimin Li, Side Liu, Qingyuan Li   +15 more
doaj   +1 more source

N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines

Cells, 2019
The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut.
Stephanie Holst, Jennifer L. Wilding, Kamila Koprowska, Yoann Rombouts, Manfred Wuhrer   +4 more
doaj   +1 more source

Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells

Engineering in Life Sciences
Cell engineering strategies typically rely on energy‐consuming overexpression of genes or radical gene‐knock out. Both strategies are not particularly convenient for the generation of slightly modulated phenotypes, as needed in biosimilar development of ...
Patrick Schlossbauer, Lukas Naumann, Florian Klingler, Madina Burkhart, René Handrick, Kathrin Korff, Christian Neusüß, Kerstin Otte, Friedemann Hesse   +8 more
doaj   +1 more source

Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages

mSystems, 2018
The milk glycobiome has a significant impact on the gut microbiota of infants, which plays a pivotal role in health and development. Fucosylated human milk oligosaccharides (HMOs) and N-glycans on milk proteins are beneficial for the development of ...
Yaqiang Bai, Jia Tao, Jiaorui Zhou, Qingjie Fan, Man Liu, Yuqi Hu, Yao Xu, Lilong Zhang, Jieli Yuan, Wenzhe Li, Xiaolei Ze, Patrice Malard, Zhimou Guo, Jingyu Yan, Ming Li   +14 more
doaj   +1 more source

A machine learning model for site-specific classification of N-glycoprotein fucosylation using tandem mass spectrometry and deep neural network

Journal of Analytical Science and Technology
Protein fucosylation is a biologically significant post-translational modification that modulates protein stability, receptor signaling, and immune function.
Mina Park, Catia Mota, Heeyoun Hwang
doaj   +1 more source

Novel insight into FCSK‐congenital disorder of glycosylation through a CRISPR‐generated cell model

Molecular Genetics & Genomic Medicine
Background FCSK‐congenital disorder of glycosylation (FCSK‐CDG) is a recently discovered rare autosomal recessive genetic disorder with defective fucosylation due to mutations in the fucokinase encoding gene, FCSK.
Maryam Fazelzadeh Haghighi, Hossein Jafari Khamirani, Jafar Fallahi, Ali Arabi Monfared, Korosh Ashrafi Dehkordi, Seyed Mohammad Bagher Tabei   +5 more
doaj   +1 more source

Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer

JCI Insight
Colon cancer affects people of all ages. However, its frequency, as well as the related morbidity and mortality, are high among older adults. The complex physiological changes in the aging gut substantially limit the development of cancer therapies. Here,
Zhihan Wang, Pan Gao, Kai Guo, Grace Schirrick, Jappreet Singh Gill, Jett Weis, Abby Lund Da Costa, Mansib Rahman, Het Mehta, Julia Fleecs, Shilpi Jain, Trishna Debnath, Junguk Hur, Nadeem Khan, Robert Sticca, Holly M. Brown-Borg, Donald A. Jurivich, Ramkumar Mathur   +17 more
doaj   +1 more source

Glycosylation Heterogeneity of α1-Acid Glycoprotein: Disease-Associated Glycoform Remodeling, Regulatory Mechanisms, and Clinical Translation. [PDF]

Biomolecules
Liu G, Fan N, Wang Y, Dong W.
europepmc   +1 more source

Longitudinal Profiling of IgG and IgA Glycosylation in Pregnancy Reveals Early Associations with BMI, Nulliparity and Conception Mode: The Rotterdam Periconception Cohort. [PDF]

Reprod Sci
Voskamp LW, Daniels A, Rousian M, van Hoek M, Wuhrer M, Steegers-Theunissen RPM, Danser AHJ, Verdonk K.   +7 more
europepmc   +1 more source