Results 61 to 70 of about 13,321 (212)

Analysis of Xyloglucan Fucosylation in Arabidopsis

Plant Physiology, 2003
AbstractXyloglucan (XyG) is a load-bearing primary wall component in dicotyledonous and non-graminaceous monocotyledonous plants. XyG fucosyltransferase (FUTase), encoded by the Arabidopsis gene AtFUT1, directs addition of fucose (Fuc) residues to terminal galactose residues on XyG side chains.
Robyn M, Perrin, Zhonghua, Jia, Tanya A, Wagner, Malcolm A, O'Neill, Rodrigo, Sarria, William S, York, Natasha V, Raikhel, Kenneth, Keegstra   +7 more
openaire   +3 more sources

FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment

Journal of Cancer, 2021
Glycosylation changes are key molecular events in tumorigenesis, progression and glycosyltransferases play a vital role in the this process. FUT8 belongs to the fucosyltransferase family and is the key enzyme involved in N-glycan core fucosylation.
Chengcheng Liao, Jiaxing An, S. Yi, Z. Tan, Hui Wang, Hao Li, Xiaoyan Guan, Jianguo Liu, Qian Wang   +8 more
semanticscholar   +1 more source

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +1 more source

A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection

Disease Models & Mechanisms, 2022
Candida infections constitute a blind spot in global public health as very few new anti-fungal drugs are being developed. Genetic surveys of host susceptibilities to such infections using mammalian models have certain disadvantages in that obtaining ...
Marcus T. Glittenberg, Ilias Kounatidis, Magda Atilano, Petros Ligoxygakis   +3 more
doaj   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulating α1,2-Fucosylation of Asah2 and Npc1

Research
Fut2-mediated α1,2-fucosylation is important for gut homeostasis, including the intestinal stem cell (ISC). The stemness of ISC declines with age, and aging-associated ISC dysfunction is closely related to many age-related intestinal diseases.
Caihan Duan, Zhe Wang, Junhao Wu, Chen Tan, Feifei Fang, Wei Qian, Chaoqun Han, X. Hou   +7 more
semanticscholar   +1 more source

Bone marrow mesenchymal stem cell-derived exosomal miR-34c-5p ameliorates RIF by inhibiting the core fucosylation of multiple proteins

Molecular Therapy, 2021
Renal interstitial fibrosis (RIF) is an incurable pathological lesion in chronic kidney diseases. Pericyte activation is the major pathological characteristic of RIF. Fibroblast and macrophage activation are also involved in RIF.
Xuemei Hu, N. Shen, Anqi Liu, Weidong Wang, Lihua Zhang, Zhigang Sui, Qingzhu Tang, Xiangning Du, Ning Yang, W. Ying, Biaojie Qin, Zhitong Li, Lin Li, Nan Wang, Hongli Lin   +14 more
semanticscholar   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

NF-κB Signaling Is Regulated by Fucosylation in Metastatic Breast Cancer Cells

Biomedicines, 2020
A growing body of evidence indicates that the levels of fucosylation correlate with breast cancer progression and contribute to metastatic disease. However, very little is known about the signaling and functional outcomes that are driven by fucosylation.
Emma H. Doud, Trupti Shetty, Melissa Abt, Amber L. Mosley, Timothy W. Corson, Anand Mehta, Elizabeth S. Yeh   +6 more
doaj   +1 more source