Results 81 to 90 of about 12,499 (209)

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Deficiency of Intestinal α1‐2‐Fucosylation Exacerbates Ethanol‐Induced Liver Disease in Mice

, 2020
BACKGROUND: Fucosyltransferase 2 (Fut2)-mediated intestinal α1-2-fucosylation is important in maintaining a symbiotic host-microbiota relationship and can protect against several pathogens.
Yanhan Wang, Cao, Jinling, Rongrong Zhou, Zhou, Rongrong, Wang, Yanhan, Gao, Bei, Vipin Kumar, Jiang, Lu, Lars Bode, Duan, Yi, Peter Stärkel, Schnabl, Bernd, Yi Duan, Lu Jiang, Jinling Cao, Xuegong Fan, Bei Gao, Cristina Llorente, Bode, Lars, Starkel, Peter, Llorente, Cristina, Bernd Schnabl, Kumar, Vipin, Fan, Xuegong   +23 more
core   +1 more source

Protein O-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals

Molecules
Domain-specific O-fucosylation is an unusual type of glycosylation, where the fucose is directly attached to the serine or threonine residues in specific protein domains via an O-linkage.
Huilin Hao, Benjamin M. Eberand, Mark Larance, Robert S. Haltiwanger   +3 more
doaj   +1 more source

Single‐Cell Glycomics of the Pancreatic Tumor Microenvironment: Technologies, Glyco‐Immune Checkpoints, and Tumor–Immune Communication

Advanced Biology, Volume 10, Issue 8, August 2026.
Single‐cell glycomics reveals how epithelial–mesenchymal transition (EMT) remodels the cancer cell glycome and reshapes communication with immune cells. Emerging technologies, including scGR‐seq and GlycoChat, uncover glyco‐immune checkpoints in pancreatic cancer, highlighting glycans as active regulators of tumor–immune interactions and providing a ...
Dinh Xuan Tuan Anh, Hiroaki Tateno
wiley   +1 more source

Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation

, 2017
Pericytes have been identified as a major source of myofibroblasts in renal interstitial fibrosis (RIF). The overactivation of several signaling pathways, mainly the TGF-β and PDGF pathways, initiates the pericyte-myofibroblast transition during RIF. Key
Nan Wang, Yiyao Deng, Qingzhu Tang, Nan Shen, Zach Odeh, Weidong Wang, Hongli Lin, Shuangxin Li, Anqi Liu, Taihua Wu, Xiangning Du   +10 more
core   +1 more source

Genetic Diseases of Fucosylation: Insights from Model Organisms

Fucosylation plays a fundamental role in maintaining cellular functions and biological processes across all animals. As a form of glycosylation, it involves the biochemical addition of fucose, a six-carbon monosaccharide, to biological molecules like ...
French, Curtis R., Ameen, Muhammad T., Curtis R. French, Muhammad T. Ameen   +3 more
core   +1 more source

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma

, 2018
De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires sequential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase (FX or tissue specific ...
Maillard, Ivan, Li, Qing, Kalady, Mathew F., Di Martino, Luca, Wang, Yiwei, Markowitz, Sanford, Awadellah, Amad, Xin, William W., Xin, Wei, Miron, Alex, Zhou, Lan, Chen, Kai-Yuan, Friedman, Ann, Xu, Yan, Fox, James G., Chan, Ricky, Cui, Min, Huang, Xiaoran, Cominelli, Fabio, Shen, Xiling, Huang, Dan, Lowe, John B., Fox, James G, Wang, Weihuan   +23 more
core   +1 more source

Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity

, 2023
Melanoma is the one of the most lethal skin malignancies due to its ability to rapidly metastasize and evade the immune system. One factor that influences melanoma’s ability to metastasize and evade the immune system is the tumor microenvironment.
Lester, Daniel K.
core  

Exploring fucosylation in lung cancer: Mechanisms, diagnosis, and therapeutic strategies

Advances in Biomarker Sciences and Technology
Lung cancer remains a global health crisis, responsible for significant morbidity and mortality. Late-stage diagnosis often limits treatment options and patient survival.
Saima Rafique, Wei Ge, Ziyuan Gao, Yan Chen, Jun Xia, Junhong Jiang, Shuang Yang   +6 more
doaj   +1 more source