Results 101 to 110 of about 13,321 (212)

Intestinal neutral ceramidase exacerbates MASH pathogenesis

eGastroenterology
Background Metabolic dysfunction-associated steatotic liver disease and its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), are intimately linked to genetic factors, gut microbiota and barrier alteration.
Chao Lei, Ting Wang, Liang Chen, Xiang Zhang, Jing Feng, Zhongbin Deng, Craig J McClain, Xiaotong Song, Amanguli Tuohongerbieke, Regina Gasparetto, Yi Tan   +10 more
doaj   +1 more source

A machine learning model for site-specific classification of N-glycoprotein fucosylation using tandem mass spectrometry and deep neural network

Journal of Analytical Science and Technology
Protein fucosylation is a biologically significant post-translational modification that modulates protein stability, receptor signaling, and immune function.
Mina Park, Catia Mota, Heeyoun Hwang
doaj   +1 more source

Novel insight into FCSK‐congenital disorder of glycosylation through a CRISPR‐generated cell model

Molecular Genetics & Genomic Medicine
Background FCSK‐congenital disorder of glycosylation (FCSK‐CDG) is a recently discovered rare autosomal recessive genetic disorder with defective fucosylation due to mutations in the fucokinase encoding gene, FCSK.
Maryam Fazelzadeh Haghighi, Hossein Jafari Khamirani, Jafar Fallahi, Ali Arabi Monfared, Korosh Ashrafi Dehkordi, Seyed Mohammad Bagher Tabei   +5 more
doaj   +1 more source

Fucosyl glycosides for DC-SIGN targeting: Fucosylation strategies, synthesis and binding studies of model compounds

Bioorganic & Medicinal Chemistry
DC-SIGN, a C-type lectin receptor expressed on immune cells, is considered a promising target for immunomodulatory and antiviral therapies. While mannose-based glycomimetics have been extensively studied as DC-SIGN ligands, fucose-based strategies remain underexplored.
Chavan, Rohit, Lefèbre, Jonathan, Jochová, Kateřina, Dvořáková, Hana, Rademacher, Christoph, Ménová, Petra   +5 more
openaire   +3 more sources

Comparison of knockdown approaches for the generation of stable cell populations expressing afucosylated antibodies. [PDF]

MAbs
Tsachaki M, Samy A, Peltret M, Brunstein Laplace T, Vaxelaire-Hily E, Mosbaoui F, Galea A, Contarin F, Duarte L, Giovannini R, Bertschinger M.   +10 more
europepmc   +1 more source

Fucosyl Monosialotetrahexosylganglioside [PDF]

, 2020
openaire   +1 more source

<i>N-</i>glycosylation alterations in expressed prostatic secretions: exploring liquid biopsy biomarkers for prostate cancer diagnosis and disease progression. [PDF]

PeerJ
Chew IYY, Jayapalan JJ, Lim J.
europepmc   +1 more source

Hematologic Glyco-Signatures: Emerging Blood-Based Sugar Codes Linked to Hyper-Aggressive Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Obeagu EI.
europepmc   +1 more source

L-Fucose: a dietary sugar with multifaceted potential in the biology and therapy of cancer. [PDF]

Nat Rev Cancer
Bitaraf A, Jimenez MC, Kakirde C, Lau EK.   +3 more
europepmc   +1 more source

A Chemoenzymatic Method To Systematically Quantify Core Fucosylation Stoichiometry of Glycoproteins and Reveal Its Roles in EMT and Embryonic Development. [PDF]

Anal Chem
Xu S, Xu X, Yin K, Wu R.
europepmc   +1 more source