Results 91 to 100 of about 12,499 (209)

N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines

Cells, 2019
The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut.
Stephanie Holst, Jennifer L. Wilding, Kamila Koprowska, Yoann Rombouts, Manfred Wuhrer   +4 more
doaj   +1 more source

Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D.

, 2015
Background RhIG is obtained from hyperimmunized healthy anti-D donors (HIDs) boosted with D+ red blood cells (RBCs). One hypothesis for its mechanism of action is fast clearance of opsonized D+ RBCs through Fcγ receptor (FcγR)III.
Agnes Hipgrave Ederveen, Ligthart, Peter, Manfred Wuhrer, van der Schoot, C.E., Della Valle, Luciana, Onno J.H.M. Verhagen, Schoot, C.E. van der, Valle, L. della, Ederveen, A.H., C. Ellen van der Schoot, Luciana Della Valle, Ligthart, P., Haas, M. de, Wuhrer, M., Kumpel, Belinda, Verhagen, Onno J. H. M., Verhagen, O.J.H.M., de Haas, M., Peter Ligthart, de Haas, Masja, Della Valle, L., Rick Kapur, Belinda Kumpel, Hipgrave Ederveen, Agnes, Kumpel, B., van der Schoot, C. Ellen, Hipgrave Ederveen, A., Vidarsson, G., Kapur, Rick, Gestur Vidarsson, Wuhrer, Manfred, Kapur, R., Verhagen, O.J., Vidarsson, Gestur, Masja de Haas   +34 more
core   +1 more source

FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis

npj Precision Oncology
Tumor competition for nutrients within the microenvironment triggers stress responses to adapt to adverse conditions; however, the mechanism by which a glucose-depleted environment influences tumor fucosylation to promote endoplasmic reticulum (ER ...
Kaiwen Qin, Haonan Zhang, Yulu Shi, Ruo Wu, Changjie Wu, Yihan Wu, Chengcheng He, Zelong Han, Yuchen Luo, Yuxin Fang, Xinrui Yan, Xinke Wang, Mingsong Li, Aimin Li, Side Liu, Qingyuan Li   +15 more
doaj   +1 more source

Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ(null) mice. [PDF]

, 2012
Delayed engraftment remains a major hurdle after cord blood (CB) transplantation. It may be due, at least in part, to low fucosylation of cell surface molecules important for homing to the bone marrow microenvironment.
Simmons, P.J., Shpall, Elizabeth J, Yang, H., Trilok, Suprita, Zweidler-McKay, P.A., Brouard, Nathalie, Javni, Jeannie A, Brouard, N., Dotti, Gianpietro, Savoldo, B., Steiner, David, Robinson, S.N., Shim, J.-S., Champlin, R.E., Robinson, Simon N, Shultz, Leonard D, Miller, Leonard, Zweidler-McKay, Patrick A, Thomas, Michael W, Steiner, D., Xing, Dongxia, Yang, Hong, Xing, D., Decker, William K, Shim, Jae-Seung, Bollard, C.M., Miller, L., , Carlsbad, Calif, United States, Dotti, G., Savoldo, Barbara, Decker, W.K., Simmons, Paul J, Shpall, E.J., Champlin, Richard E, Thomas, M.W., Javni, J.A., Bollard, Catherine M, Trilok, S., Shultz, L.D.   +37 more
core   +1 more source

Abstract 895: Fucosylation inhibits invadopodia formation and melanoma invasion

, 2017
Background: Melanoma is the most deadly skin cancer and metastasis is essentially responsible for all melanoma related death. Recently, fucose treatment has been shown to inhibit melanoma cell migration and invasion in vitro, and melanoma metastasis in a
Eric Lau, Tyler S. Keeley, Shengyu Yang
core   +1 more source

Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages

mSystems, 2018
The milk glycobiome has a significant impact on the gut microbiota of infants, which plays a pivotal role in health and development. Fucosylated human milk oligosaccharides (HMOs) and N-glycans on milk proteins are beneficial for the development of ...
Yaqiang Bai, Jia Tao, Jiaorui Zhou, Qingjie Fan, Man Liu, Yuqi Hu, Yao Xu, Lilong Zhang, Jieli Yuan, Wenzhe Li, Xiaolei Ze, Patrice Malard, Zhimou Guo, Jingyu Yan, Ming Li   +14 more
doaj   +1 more source

TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2

, 2020
Background: TSTA3 gene encodes an enzyme responsible for synthesis of GDP-L-fucose as the only donor in fucosylation. This study was designed to explore clinical value, function and underlying mechanism of TSTA3 in the development of esophageal squamous ...
Cheng, Xiaolong, Yan, Ting, Qian, Yu, Gao, Yingzhen, Zhang, Xiaojuan, Li, Hongyi, Wang, Fang, Cui, Yongping, Bi, Yanghui, Kong, Pengzhou, Niu, Xia, Guo, Min, Ma, Yanchun, Xu, Jing, Cui, Heyang, Yang, Jian, Yang, Jie, Liu, Feng, Zhang, Ling   +18 more
core   +1 more source

Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells

Engineering in Life Sciences
Cell engineering strategies typically rely on energy‐consuming overexpression of genes or radical gene‐knock out. Both strategies are not particularly convenient for the generation of slightly modulated phenotypes, as needed in biosimilar development of ...
Patrick Schlossbauer, Lukas Naumann, Florian Klingler, Madina Burkhart, René Handrick, Kathrin Korff, Christian Neusüß, Kerstin Otte, Friedemann Hesse   +8 more
doaj   +1 more source

Applying Acylated Fucose Analogues to Metabolic Glycoengineering

Bioengineering, 2015
Manipulations of cell surface glycosylation or glycan decoration of selected proteins hold immense potential for exploring structure-activity relations or increasing glycoprotein quality.
Julia Rosenlöcher, Verena Böhrsch, Michael Sacharjat, Véronique Blanchard, Christoph Giese, Volker Sandig, Christian P. R. Hackenberger, Stephan Hinderlich   +7 more
doaj   +1 more source

Intestinal Fucosylation: A Key Regulatory Hub in Homeostasis and Disease Pathogenesis

Biomolecules
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal disorders that pose significant threats to human health and share common pathological features, including intestinal mucosal barrier disruption and gut microbiota ...
Zhishan Xu, Dingbo Song, Fangqi Hu, Qiuhan Liang, Mengyao Zhang, Chao Lei, Jinyuan Li, Haiyi Guo, Zhongbin Deng, Zishan Yang   +9 more
doaj   +1 more source