Results 71 to 80 of about 12,499 (209)

Multi-Path Optimization for Efficient Production of 2′-Fucosyllactose in an Engineered Escherichia coli C41 (DE3) Derivative

Frontiers in Bioengineering and Biotechnology, 2020
2′-fucosyllactose (2′-FL), one of the simplest but most abundant oligosaccharides in human milk, has been demonstrated to have many positive benefits for the healthy development of newborns.
Zhijian Ni, Zhijian Ni, Zhongkui Li, Zhongkui Li, Jinyong Wu, Jinyong Wu, Yuanfei Ge, Yuanfei Ge, Yingxue Liao, Yingxue Liao, Lixia Yuan, Lixia Yuan, Xiangsong Chen, Xiangsong Chen, Jianming Yao, Jianming Yao   +15 more
doaj   +1 more source

Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2605-2612, October 2026.
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora, Chen‐Lin Hsieh, Sanne Schoffelen, Johnny Arnsdorf, Eric A. Toth, Abdul S. Yunus, Thomas E. Cleveland IV, Sara Petersen Bjørn, Mina Ying Min Wu, Noel G. McElvaney, Bjørn Gunnar Rude Voldborg, Thomas R. Fuerst, Nathan E. Lewis   +12 more
wiley   +1 more source

Glycoproteomic Signatures of IgG Subclass N‐Glycosylation Reveal Molecular Endotypes in Idiopathic Inflammatory Myopathies

MedComm, Volume 7, Issue 10, October 2026.
• EThcD‐sceHCD‐MS/MS and updated PANDA software decode IgG N‐glycosylation in IIMs. • Unsupervised clustering reveals three novel glyco‐endotypes matching clinical phenotypes. • A seven‐glycopeptide model enables robust endotype prediction beyond conventional subtypes.
Tong Wu, Yanhong Li, Yingying Ling, Yinlan Wu, Jing Zhao, Lu Cheng, Chunyu Tan, Yi Zhang, Yong Zhang, Yi Liu   +9 more
wiley   +1 more source

Fucosylation of human hematopoietic stem cells enhances engraftment and self-renewal through modulated e-selectin interactions and intracellular signaling

Hematopoietic stem cell transplantation (HSCT) efficacy is often limited by inefficient stem cell delivery to the bone marrow and challenges in maintaining transplanted hematopoietic stem cell (HSC) pools.
Bensaddek, Dalila, Zhang, Huoming, Al-Amoodi, Asma, Li, Yanyan, Kai, Jing, Haboshi, Satoshi, Alghuneim, Arwa, Merzaban, Jasmeen S., Nozue, Shuho, Malki, Jana S.   +9 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, Volume 16, Issue 9, Page 1708-1725, September 2026.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Protein and Site Specificity of Fucosylation in Liver-Secreted Glycoproteins

, 2015
Chronic liver diseases are a serious health problem worldwide. One of the frequently reported glycan alterations in liver disease is aberrant fucosylation, which was suggested as a marker for noninvasive serologic monitoring. We present a case study that
David J. Ashline (1345581), Petr Pompach (382130), Zuzana Brnakova (1325661), Radoslav Goldman (10706), Julius Benicky (1341801), Miloslav Sanda (1325664)   +5 more
core   +1 more source

IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background Altered immunoglobulin G (IgG) glycosylation was implicated in various conditions, but its role in fibromyalgia (FM) remains unclear. This study investigated IgG glycosylation patterns in FM patients and associations between glycosylation changes and clinical profiles.
Ling‐Cheng Kung, Nguyen Thanh Nhu, Yu‐Ying Yu, I‐Lin Tsai, Jiunn‐Horng Kang   +4 more
wiley   +1 more source

Fucosyl gangliosides of PC12 pheochromocytoma cells [PDF]

FEBS Letters, 1984
Three monosialogangliosides are highly labeled when PC12 pheochromocytoma cells are cultured in the presence of L‐[3H] fucose, and two additional monosialogangliosides are labeled to a lesser extent. In contrast, neither of the two disialogangliosides of PC12 cells contains fucose residues.
Margolis, R.U., Mazzulla, M., Greene, L.A., Margolis, R.K.   +3 more
openaire   +2 more sources

Novel function of pregnancy-associated plasma protein A: promotes endometrium receptivity by up-regulating N-fucosylation

Scientific Reports, 2017
Glycosylation of uterine endometrial cells plays important roles to determine their receptive function to blastocysts. Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pregnant women serum, and is known to ...
Ming Yu, Jiao Wang, Shuai Liu, Xiaoqi Wang, Qiu Yan   +4 more
doaj   +1 more source

Profiling the Glycosignature of Commercial Pepsin‐Soluble Type I Collagen Preparations: A MultiModal Lectin Strategy Reveals Latent Batch Variability

Journal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.
ABSTRACT Type I collagen (Col‐I) is widely used in biomaterials and cell biology, yet the glycosignature of commercial Col‐I preparations remains poorly characterized. Here, we established an integrated lectin‐based workflow to profile the glycan landscape of commercially sourced bovine pepsin‐soluble Col‐I as supplied for biomaterial use.
Mohamed EL‐Melegy, Amir M. Alsharabasy, Abhay Pandit   +2 more
wiley   +1 more source