Results 31 to 40 of about 12,499 (209)
From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]
, 2009 Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine +4 more
core +1 more source
Journal of Translational Medicine, 2023 Background Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate the effect and underlying mechanism
Weijun Wang +8 more
doaj +1 more source
Semisynthetic Isomers of Fucosylated Chondroitin Sulfate Polysaccharides with Fucosyl Branches at a Non-Natural Site [PDF]
Biomacromolecules, 2021 The several interesting activities detected for fucosylated chondroitin sulfate (fCS) have fueled in the last years several efforts toward the obtainment of fCS oligosaccharides and low molecular weight (LMW) polysaccharides with a well-defined structure, in order to avoid the problems associated with the potential employment of native, sea cucumber ...
Vessella, Giulia +7 more
openaire +3 more sources
Fragmentation characteristics of glycopeptides [PDF]
, 2013 Mass spectrometric analysis of glycopeptides is an emerging strategy for analysis of glycosylation patterns. Here we present an approach using energy resolved collision induced decomposition (CID) spectra to determine structural features of glycopeptides.
Jekő, Anita +6 more
core +1 more source
Advances in the study of core fucosylation in mammals
浙江大学学报. 农业与生命科学版, 2021 Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase.
TIAN Yinping, YI Wen
doaj +1 more source
Fucosylated glycoproteins and fucosylated glycolipids play opposing roles in cholera intoxication
, 2023 SUMMARY Cholera toxin (CT) is the etiological agent of cholera. Here we report that multiple classes of fucosylated glycoconjugates function in CT binding and intoxication of intestinal epithelial cells. In Colo205 cells, knockout of B3GNT5, the enzyme required for synthesis of lacto- and neolacto-series glycosphingolipids (GSLs ...
Atossa C. Ghorashi +9 more
openaire +2 more sources
Frontiers in Chemistry, 2020 Changes in the abundance of antennary fucosylated glycans in human total plasma N-glycome (TPNG) have been associated with several diseases ranging from diabetes to various forms of cancer. However, it is challenging to address this important part of the
Osmond D. Rebello +10 more
doaj +1 more source
Fucosylation and gastrointestinal cancer
World Journal of Hepatology, 2010 Fucose (6-deoxy-L-galactose) is a monosaccharide that is found on glycoproteins and glycolipids in verte-brates, invertebrates, plants, and bacteria. Fucosylation, which comprises the transfer of a fucose residue to oligosaccharides and proteins, is regulated by many kinds of molecules, including fucosyltransferases, GDP-fucose synthetic enzymes, and ...
Kenta, Moriwaki, Eiji, Miyoshi
openaire +2 more sources
Frontiers in Physiology, 2017 Cancer pain is a common and severe complication of human breast cancer, and relieving pain is fundamental strategy in the treatment. Fentanyl, as an opioid analgesic, is widely used in breast cancer patients. However, little is known about its effects on
Hong-Fang Yang +7 more
doaj +1 more source
Genome Biology, 2002 A biocomputational study of the fruitfly genome reveals the presence of new genes putatively involved in ...
openaire +1 more source