Results 21 to 30 of about 12,499 (209)
Cellular Fucosylation Inhibitors Based on Fluorinated Fucose-1-Phosphates [PDF]
, 2020 Fucosylation of glycans impacts a myriad of physiological and pathological processes. Inhibition of fucose expression emerges as a potential therapeutic avenue for example in cancer, inflammation, and infection.
Marek, Noga +7 more
core +2 more sources
Pathogenetic, Prognostic, and Therapeutic Role of Fucosylation in Intrahepatic Cholangiocarcinoma [PDF]
, 2023 Summary Intrahepatic cholangiocarcinoma (iCCA) is one of the most lethal forms of primary liver cancer. The incidence of iCCA is growing worldwide, and limited therapeutic options exist for this aggressive tumor.
Ament, Cindy Eva
core +1 more source
Frontiers in Microbiology, 2020 The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao +8 more
doaj +1 more source
Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis. [PDF]
PLoS ONE, 2013 Fucosylation is a crucial oligosaccharide modification in cancer. The known function of fucosylation in cancer is to mediate metastasis through selectin ligand-dependent processes.
Kotarosumitomo Nakayama +6 more
doaj +1 more source
Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity
Frontiers in Immunology, 2022 Most of the membrane molecules involved in immune response are glycosylated. N-glycans linked to asparagine (Asn) of immune molecules contribute to the protein conformation, surface expression, stability, and antigenicity.
Yuhan Sun +4 more
doaj +1 more source
Fluorinated Mannosides Inhibit Cellular Fucosylation. [PDF]
, 2020 Fucose sugars are expressed on mammalian cell membranes as part of glycoconjugates and mediates essential physiological processes. The aberrant expression of fucosylated glycans has been linked to pathologies such as cancer, inflammation, infection, and ...
Willem, Titulaer +6 more
core +2 more sources
Cells, 2023 Various tumors rely on post-translational modifications (PTMs) to promote invasiveness and angiogenesis and to reprogram cellular energetics to abate anti-cancer immunity.
Gabriele Antonarelli +6 more
doaj +1 more source
Structure of human POFUT2 : insights into thrombospondin type 1 repeat fold and O-fucosylation [PDF]
, 2012 Protein O-fucosylation is a post-translational modification found on epidermal growth factor-like (EGF) repeats and thrombospondin type 1 repeats (TSR).
Chun-I, Chen
core +1 more source
Insights into protein fucosylation in insects
, 2023 Fucosylation, or the attachment of a fucose moiety to a glycan or protein by the action of fucosyltransferases, happens extensively in all living organisms.
De Schutter, Kristof, Yang, Qun
core +1 more source
Cell Death and Disease, 2021 Vaginal dysbiosis often occurs in patients with cervical cancer. The fucosylation of mucosal epithelial cells is closely related to microbial colonization, and play an important role in protecting the vaginal mucosal epithelial cells. However, no reports
Qingjie Fan +10 more
doaj +1 more source