Results 21 to 30 of about 13,321 (212)
Redox Biology, 2023 The intestinal epithelial repair after injury is coordinated by intestinal stem cells (ISCs). Fucosylation catalyzed by fucosyltransferase 2 (FUT2) of the intestinal epithelium is beneficial to mucosal healing but poorly defined is the influence on ISCs.
Zhe Wang +8 more
semanticscholar +1 more source
Multi-targeted therapy resistance via drug-induced secretome fucosylation
eLife, 2023 Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive.
Mark Borris D Aldonza +19 more
doaj +1 more source
Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis. [PDF]
PLoS ONE, 2013 Fucosylation is a crucial oligosaccharide modification in cancer. The known function of fucosylation in cancer is to mediate metastasis through selectin ligand-dependent processes.
Kotarosumitomo Nakayama +6 more
doaj +1 more source
Nature Cancer, 2023 Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment.
Daniel K. Lester +35 more
semanticscholar +1 more source
Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. [PDF]
PLoS ONE, 2010 We previously reported increased levels of protein-linked fucosylation with the development of liver cancer and identified many of the proteins containing the altered glycan structures. One such protein is alpha-1-antitrypsin (A1AT).
Mary Ann Comunale +7 more
doaj +1 more source
Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies
Frontiers in Immunology, 2022 The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly enhances the efficacy of antibody dependent cellular cytotoxicity (ADCC)
J. Golay, Alain E Andrea, I. Cattaneo
semanticscholar +1 more source
FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation
Cell Communication and Signaling, 2023 Background Fucosyltransferase 2(FUT2) and its induced α-1,2 fucosylation is associated with cancer metastasis. However, the role of FUT2 in colorectal cancer (CRC) metastasis remains unclear.
Ling-fang He +4 more
semanticscholar +1 more source
Antibody Therapeutics, 2023 Aberrant post-translational glycosylation is a well-established hallmark of cancer. Altered core fucosylation mediated by α-(1,6)-fucosyltransferase (Fut8) is one of the key changes in tumor glycan patterns that contributes to neoplastic transformation ...
C. Mao, Jun Li, Li-li Feng, Wenda Gao
semanticscholar +1 more source
SPINDLY mediates O-fucosylation of hundreds of proteins and sugar-dependent growth in Arabidopsis
The Plant Cell, 2023 The recent discovery of SPINDLY (SPY)-catalyzed protein O-fucosylation revealed a novel mechanism for regulating nucleocytoplasmic protein functions in plants.
Yang Bi +14 more
semanticscholar +1 more source
Glycobiology, 2023 Aberrant glycosylation is a hallmark of cancer and is not just a consequence, but also a driver of a malignant phenotype. In prostate cancer, changes in fucosylated and sialylated glycans are common and this has important implications for tumor ...
Margarita Orozco-Moreno +15 more
semanticscholar +1 more source