Results 11 to 20 of about 13,321 (212)

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis

Arthritis Research & Therapy, 2022
Background Osteoarthritis (OA) is the most common form of arthritis and is characterized by the degradation of articular cartilage and inflammation of the synovial membrane.
Hanjie Yu, Mingxiu Li, Xiaodong Wen, Jie Yang, Xiaojun Liang, Xia Li, Xiaojuan Bao, Jian Shu, Xiameng Ren, Wentian Chen, Zheng Li, Yi Li   +11 more
doaj   +2 more sources

Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

Cell Reports, 2023
Summary: As highly organized consortia of bacteria, biofilms have long been implicated in aggravating inflammation. However, our understanding regarding in vivo host-biofilm interactions in the complex tissue environments remains limited. Here, we show a
Xue-Kun Guo, Jiali Wang, Vincent P. van Hensbergen, Jintao Liu, Huji Xu, Xiaoyu Hu   +5 more
doaj   +2 more sources

Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM

Journal of Translational Medicine, 2023
Background Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate the effect and underlying mechanism
Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou, Rong Lin   +8 more
doaj   +2 more sources

Lactobacillus spp. create a protective micro-ecological environment through regulating the core fucosylation of vaginal epithelial cells against cervical cancer

Cell Death and Disease, 2021
Vaginal dysbiosis often occurs in patients with cervical cancer. The fucosylation of mucosal epithelial cells is closely related to microbial colonization, and play an important role in protecting the vaginal mucosal epithelial cells. However, no reports
Qingjie Fan, Yuanhang Wu, Mechou Li, Fan An, Lulu Yao, Meixian Wang, Xiuying Wang, Jieli Yuan, Kui Jiang, Wenzhe Li, Ming Li   +10 more
doaj   +2 more sources

Fluorinated rhamnosides inhibit cellular fucosylation [PDF]

Nature Communications, 2021
Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development.
Johan F. A. Pijnenborg, Emiel Rossing, Jona Merx, Marek J. Noga, Willem H. C. Titulaer, Nienke Eerden, Raisa Veizaj, Paul B. White, Dirk J. Lefeber, Thomas J. Boltje   +9 more
doaj   +4 more sources

Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer

JCI Insight
Colon cancer affects people of all ages. However, its frequency, as well as the related morbidity and mortality, are high among older adults. The complex physiological changes in the aging gut substantially limit the development of cancer therapies. Here,
Zhihan Wang, Pan Gao, Kai Guo, Grace Schirrick, Jappreet Singh Gill, Jett Weis, Abby Lund Da Costa, Mansib Rahman, Het Mehta, Julia Fleecs, Shilpi Jain, Trishna Debnath, Junguk Hur, Nadeem Khan, Robert Sticca, Holly M. Brown-Borg, Donald A. Jurivich, Ramkumar Mathur   +17 more
doaj   +2 more sources

FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis

Molecular Medicine, 2023
Backgrounds Renal fibrosis is a common pathologic process of most chronic kidney diseases (CKDs), becoming one of the major public health problems worldwide.
Jialiang Luo, Kaifeng Mao, Zhengyumeng Zhu, Junli Ye, Lei Li, Di Wang, Jia Zhou, Fenwang Lin, Juan Li, Junsheng Ye   +9 more
doaj   +1 more source

Fucosylation in prokaryotes and eukaryotes [PDF]

Glycobiology, 2006
Fucosylated carbohydrate structures are involved in a variety of biological and pathological processes in eukaryotic organisms including tissue development, angiogenesis, fertilization, cell adhesion, inflammation, and tumor metastasis. In contrast, fucosylation appears less common in prokaryotic organisms and has been suggested to be involved in ...
Bing, Ma, Joanne L, Simala-Grant, Diane E, Taylor   +2 more
openaire   +2 more sources

Fucosylated Proteome Profiling Identifies a Fucosylated, Non-Ribosomal, Stress-Responsive Species of Ribosomal Protein S3

Cells, 2021
Alterations in genes encoding for proteins that control fucosylation are known to play causative roles in several developmental disorders, such as Dowling-Degos disease 2 and congenital disorder of glycosylation type IIc (CDGIIc).
Gregory Watson, Daniel Lester, Hui Ren, Connor M. Forsyth, Elliot Medina, David Gonzalez Perez, Lancia Darville, Jiqiang Yao, Vince Luca, John Koomen, Ling Cen, Eric Lau   +11 more
doaj   +1 more source

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Science Translational Medicine, 2021
High titers and low fucosylation of human anti–spike protein IgG promote alveolar macrophage activation and inflammation. Activating antibodies Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
W. Hoepel, Hung-Jen Chen, Chiara E. Geyer, Sona Allahverdiyeva, X. D. Manz, S. D. de Taeye, J. Aman, L. Mes, Maurice Steenhuis, G. Griffith, P. Bonta, P. Brouwer, Tom G. Caniels, K. van der Straten, Korneliusz Golebski, R. Jonkers, M. Larsen, Federica Linty, J. Nouta, C. V. van Roomen, F. V. van Baarle, C. V. van Drunen, G. Wolbink, A. Vlaar, G. D. de Bree, R. Sanders, Lisa Willemsen, A. Neele, D. van de Beek, T. Rispens, M. Wuhrer, H. Bogaard, M. V. van Gils, G. Vidarsson, M. D. de Winther, J. den Dunnen   +35 more
semanticscholar   +1 more source