Results 11 to 20 of about 12,499 (209)
Multi-targeted therapy resistance via drug-induced secretome fucosylation [PDF]
eLife, 2023 Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive.
Mark Borris D Aldonza +19 more
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[Role of Fucosylation in Cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2016 Fucosylation is one of the most important glycosylation in mamal, involving biosynthesis of blood H antigen and Lewis antigen, selectin mediated intravasion and homing of leukocyte, host-microbe interactions, modification of signaling. Alterations in the expression of fucosylated oligosaccharides have been observed in several cancer, playing a role in ...
Kun ZHANG, Hong WANG
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Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. [PDF]
PLoS ONE, 2010 We previously reported increased levels of protein-linked fucosylation with the development of liver cancer and identified many of the proteins containing the altered glycan structures. One such protein is alpha-1-antitrypsin (A1AT).
Mary Ann Comunale +7 more
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Fluorinated rhamnosides inhibit cellular fucosylation [PDF]
Nature Communications, 2021 Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development.
Johan F. A. Pijnenborg +9 more
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NF-κB Signaling Is Regulated by Fucosylation in Metastatic Breast Cancer Cells
Biomedicines, 2020 A growing body of evidence indicates that the levels of fucosylation correlate with breast cancer progression and contribute to metastatic disease. However, very little is known about the signaling and functional outcomes that are driven by fucosylation.
Emma H. Doud +6 more
doaj +3 more sources
Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation
Frontiers in Immunology, 2018 CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Naoyuki Taniguchi +2 more
exaly +3 more sources
FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis
Molecular Medicine, 2023 Backgrounds Renal fibrosis is a common pathologic process of most chronic kidney diseases (CKDs), becoming one of the major public health problems worldwide.
Jialiang Luo +9 more
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Cells, 2021 Alterations in genes encoding for proteins that control fucosylation are known to play causative roles in several developmental disorders, such as Dowling-Degos disease 2 and congenital disorder of glycosylation type IIc (CDGIIc).
Gregory Watson +11 more
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Fucosylation in prokaryotes and eukaryotes [PDF]
Glycobiology, 2006 Fucosylated carbohydrate structures are involved in a variety of biological and pathological processes in eukaryotic organisms including tissue development, angiogenesis, fertilization, cell adhesion, inflammation, and tumor metastasis. In contrast, fucosylation appears less common in prokaryotic organisms and has been suggested to be involved in ...
Bing, Ma +2 more
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Arthritis Research & Therapy, 2022 Background Osteoarthritis (OA) is the most common form of arthritis and is characterized by the degradation of articular cartilage and inflammation of the synovial membrane.
Hanjie Yu +11 more
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