Results 11 to 20 of about 10,058 (125)

Fucose metabolism as a central axis linking inflammation, immunity, and cancer in the gut [PDF]

Frontiers in Immunology
Fucose metabolism and fucosylation are emerging as central regulators of intestinal epithelial integrity, immune homeostasis, host-microbiota interactions, and tumor progression.
Dhirendra K. Singh, Chieko Saito, Yukihiro Yamaguchi, Olivia G. Cassidy, Keita Nishiyama, Lei Huang   +5 more
doaj   +2 more sources

Fucosylation Dynamics as a Critical Determinant of Cancer Cell Fate in Colorectal Carcinoma: Integrating Hallmark Plasticity, Microenvironmental Remodelling, and Therapeutic Resistance [PDF]

Biology
Fucosylation, the enzymatic addition of fucose residues to glycans, modulates receptor signalling and cellular identity in the intestinal epithelium. Its role as an integrative determinant of cancer cell fate in colorectal cancer (CRC) remains undefined.
Abdulaziz Alfahed, Abdulrahman A. Alahmari, Glowi Alasiri   +2 more
doaj   +2 more sources

Fucosylated hemocyanin regulates ER stress to enhance shrimp antibacterial immunity [PDF]

Virulence
Invertebrates rely on post-translational modifications (PTMs) of immune effectors to regulate innate immunity, yet how hemocyanin fucosylation mediates intracellular antimicrobial signaling remains a critical knowledge gap in crustacean immunology ...
Mingming Jiang, Junyang Zhou, Xinyue Ren, Yiqi Liu, Jiawei Cheng, Yueling Zhang, Zhihong Zheng   +6 more
doaj   +2 more sources

Intestinal Fucosylation: A Key Regulatory Hub in Homeostasis and Disease Pathogenesis [PDF]

Biomolecules
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal disorders that pose significant threats to human health and share common pathological features, including intestinal mucosal barrier disruption and gut microbiota ...
Zhishan Xu, Dingbo Song, Fangqi Hu, Qiuhan Liang, Mengyao Zhang, Chao Lei, Jinyuan Li, Haiyi Guo, Zhongbin Deng, Zishan Yang   +9 more
doaj   +2 more sources

FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease [PDF]

Frontiers in Microbiology
Intestinal fucosylation, the enzymatic addition of fucose to glycoconjugates, represents a pivotal regulatory mechanism that modulates host–microbiota crosstalk in the gastrointestinal tract.
Lifen Zhao, Nianzhu Zhang
doaj   +2 more sources

Defective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia [PDF]

Nature Communications
Preeclampsia (PE) is a severe pregnancy disorder caused by placental dysfunction. Protein O-fucosylation is a type of protein post translational modification that is catalyzed by protein O-fucosyltransferases (poFUTs).
Yaqi Li, Hongpan Wu, Yuyu Lei, Shuyu Bai, Jiao Wang, Bin Yan, Yubo Liu, Shuai Liu   +7 more
doaj   +2 more sources

Intestinal neutral ceramidase exacerbates MASH pathogenesis [PDF]

eGastroenterology
Background Metabolic dysfunction-associated steatotic liver disease and its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), are intimately linked to genetic factors, gut microbiota and barrier alteration.
Chao Lei, Ting Wang, Liang Chen, Xiang Zhang, Jing Feng, Zhongbin Deng, Craig J McClain, Xiaotong Song, Amanguli Tuohongerbieke, Regina Gasparetto, Yi Tan   +10 more
doaj   +2 more sources

FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [PDF]

PLoS Pathogens
Understanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Limeng Sun, Yixin Xiang, Yichen Yang, Yubei Tan, Zhelin Su, Zhen Fu, Yanan Fu, Shengsong Xie, Guiqing Peng   +8 more
doaj   +2 more sources

Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis. [PDF]

PLoS ONE, 2013
Fucosylation is a crucial oligosaccharide modification in cancer. The known function of fucosylation in cancer is to mediate metastasis through selectin ligand-dependent processes.
Kotarosumitomo Nakayama, Kenta Moriwaki, Taku Imai, Shinichiro Shinzaki, Yoshihiro Kamada, Kohei Murata, Eiji Miyoshi   +6 more
doaj   +1 more source

Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM

Journal of Translational Medicine, 2023
Background Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate the effect and underlying mechanism
Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou, Rong Lin   +8 more
doaj   +1 more source