Results 1 to 10 of about 13,568 (269)

FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [PDF]

PLoS Pathogens
Understanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Limeng Sun, Yixin Xiang, Yichen Yang, Yubei Tan, Zhelin Su, Zhen Fu, Yanan Fu, Shengsong Xie, Guiqing Peng   +8 more
doaj   +2 more sources

The contribution of fucosyltransferases to cancer biology [PDF]

Brazilian Journal of Biology
Fucosyltransferases are enzymes that transfer L-fucose residues from a donor substrate to target molecules. These enzymes are encoded by genes known as FUTs (FUT1 to FUT-11), along with POFUT1 and 2.
A. O. Vasconcelos, L. M. Vieira, C. R. C. Rocha, E. I. C. Beltrão   +3 more
doaj   +3 more sources

Enzyme Reset: Water-Mediated Tautomerization Restores the Catalytic Asparagine in Protein <i>O</i>-Fucosyltransferase 1. [PDF]

J Chem Inf Model
Vidal-Gironès Ò, Trizio E, Kang P, Parrinello M, Rivas-Fernández JP, Rovira C.   +5 more
europepmc   +2 more sources

Correlation Of Fut2 And Fut3 Gene Polymorphisms With Inflammatory Bowel Disease In Guangxi Zhuang Population [PDF]

International Journal of General Medicine
Xiaodan Lv,1,* Zhou Huang,2,* Shiquan Li,3 Xiaofang Xu,3 Deyi Chen,3 Lichun Han,3 Yu He,1 Shan Huang,1 Huiling Wu,1 Yunwei Qi,1 Liqiang Wei,1 Min Chen,1 Lingling Zhan,1 Xiaoping Lv3 1Department of Clinical Laboratory, the First Affiliated ...
Lv X, Huang Z, Li S, Xu X, Chen D, Han L, He Y, Huang S, Wu H, Qi Y, Wei L, Chen M, Zhan L, Lv X   +13 more
doaj   +2 more sources

Utility of Bioluminescent Homogeneous Nucleotide Detection Assays in Measuring Activities of Nucleotide-Sugar Dependent Glycosyltransferases and Studying Their Inhibitors

Molecules, 2021
Traditional glycosyltransferase (GT) activity assays are not easily configured for rapid detection nor for high throughput screening because they rely on radioactive product isolation, the use of heterogeneous immunoassays or mass spectrometry.
Laurie Engel, Juliano Alves, Jacquelyn Hennek, Said A. Goueli, Hicham Zegzouti   +4 more
doaj   +1 more source

Structural Insights in Mammalian Sialyltransferases and Fucosyltransferases: We Have Come a Long Way, but It Is Still a Long Way Down

Molecules, 2021
Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive ...
Ravneet Kaur Grewal, Abdul Rajjak Shaikh, Suresh Gorle, Manjeet Kaur, Paula Alexendra Videira, Luigi Cavallo, Mohit Chawla   +6 more
doaj   +1 more source

Anaplasma marginale Infection of Dermacentor andersoni Primary Midgut Cell Culture Is Dependent on Fucosylated Glycans

Frontiers in Cellular and Infection Microbiology, 2022
Tick midgut is the primary infection site required by tick-borne pathogens to initiate their development for transmission. Despite the biological significance of this organ, cell cultures derived exclusively from tick midgut tissues are unavailable and ...
Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell C. Johnson, Hala E. Hussein, Hala E. Hussein, Naomi S. Taus, Kelly A. Brayton, Ulrike G. Munderloh, Susan M. Noh, Susan M. Noh, Massaro W. Ueti, Massaro W. Ueti, Massaro W. Ueti   +12 more
doaj   +1 more source

Novel Insights Into N-Glycan Fucosylation and Core Xylosylation in C. reinhardtii

Frontiers in Plant Science, 2020
Chlamydomonas reinhardtii (C. reinhardtii) N-glycans carry plant typical β1,2-core xylose, α1,3-fucose residues, as well as plant atypical terminal β1,4-xylose and methylated mannoses. In a recent study, XylT1A was shown to act as core xylosyltransferase,
Anne Oltmanns, Lara Hoepfner, Martin Scholz, Karen Zinzius, Stefan Schulze, Stefan Schulze, Michael Hippler, Michael Hippler   +7 more
doaj   +1 more source

Fucosyltransferase 9 promotes neuronal differentiation and functional recovery after spinal cord injury by suppressing the activation of Notch signaling

Acta Biochimica et Biophysica Sinica, 2023
Individuals with spinal cord injury (SCI) suffer from permanent disabilities such as severe motor, sensory and autonomic dysfunction.
Chen Jiewen, Zeng Xiaolin, Zhang Wenwu, Li Gang, Zhong Haoming, Xu Chengzhong, Li Xiang, Lin Tao   +7 more
doaj   +1 more source

Establishment and identification of a human megakaryocytic cell line with low Ley expression

Zhongguo shuxue zazhi, 2022
Objective To establish a stable human megakaryocytic cell line with low expression of Ley antigen to further study the role of Ley on activation of platelets.
Huijun ZHU, Qinqin MA, Fengyong ZHAO, Qin LI, Ping LU   +4 more
doaj   +1 more source