FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ihara, H +3 more
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Subcellular localisation of cerebral fucosyltransferase [PDF]
FEBS Letters, 1984 GDP‐fucose : asialofetuin fucosyltransferase from sheep brain was fractionated on a sucrose gradient into two activity peaks. Using purification on Ficoll adapted from the proposed method [(1980) J. Neurochem. 35, 281‐296], double localisation of cerebral fucosyltransferase was confirmed and the subcellular active fractions identified as light ...
Broquet, P. +4 more
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An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei [PDF]
eLife, 2021 Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar GDP-Fuc has been ...
Giulia Bandini +7 more
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Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis. [PDF]
PLoS ONE, 2017 The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-
Rieko Ajima, Emiko Suzuki, Yumiko Saga
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Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase [PDF]
Nature Communications, 2020 Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García +6 more
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Enzymatic Synthesis of a Fluorogenic Reporter Substrate and a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation [PDF]
, 2019 We report a straight-forward enzymatic synthesis of the 4-methylumbelliferyl glycoside of a complex-type oligosaccharide substrate for core-fucosylation.
Maxim Soroko, David H. Kwan
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Cloning and expression analysis of maize fucosyltransferase gene SPINDLY [PDF]
Guangxi ZhiwuSPINDLY(SPY)is a novel nucleocytoplasmic protein O-fucosyltransferase that regulates target protein activity or stability via O-fucosylation. Previous studies have indicated that the SPY protein regulates plant growth and development by modulating ...
LI Bowen, WANG Zhiqin, ZHU Xiaona, ZHU Zhenyu, GAO Xiaoxiao*
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Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology
Frontiers in Genetics, 2020 Otitis media (OM) is an infective and inflammatory disorder known to be a major cause of hearing impairment across all age groups. Both acute and chronic OM result in substantial healthcare utilization related to antibiotic prescription and surgical ...
Arnaud P. J. Giese +5 more
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Allele frequency of A385T in Fucosyltransferase 2 gene (FUT2) among Southern Thai population [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2020 Fucosyltransferase 2 gene (FUT2) gene plays an important role in control of enzymes that secrete blood type antigen substances. The mutation of FUT2 at nucleotide position 385 from A to T (A385T) combined with secretor phenotype is associated with ...
Darinnat Buathong +2 more
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Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY
Nature Communications, 2023 Kumar and colleagues report cryo-EM structures of Arabidopsis O-fucosyltransferase SPINDLY in its apo and GDP-fucose bound states, revealing distinct active-site features enabling GDP-fucose recognition and surprisingly dynamic conformations that ...
Shivesh Kumar +14 more
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