Acta Biochimica et Biophysica Sinica, 2023 Individuals with spinal cord injury (SCI) suffer from permanent disabilities such as severe motor, sensory and autonomic dysfunction.
Chen Jiewen +7 more
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Establishment and identification of a human megakaryocytic cell line with low Ley expression
Zhongguo shuxue zazhi, 2022 Objective To establish a stable human megakaryocytic cell line with low expression of Ley antigen to further study the role of Ley on activation of platelets.
Huijun ZHU +4 more
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FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [PDF]
PLoS PathogUnderstanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Sun L +8 more
europepmc +2 more sources
Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology
Frontiers in Genetics, 2020 Otitis media (OM) is an infective and inflammatory disorder known to be a major cause of hearing impairment across all age groups. Both acute and chronic OM result in substantial healthcare utilization related to antibiotic prescription and surgical ...
Arnaud P. J. Giese +5 more
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Allele frequency of A385T in Fucosyltransferase 2 gene (FUT2) among Southern Thai population [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2020 Fucosyltransferase 2 gene (FUT2) gene plays an important role in control of enzymes that secrete blood type antigen substances. The mutation of FUT2 at nucleotide position 385 from A to T (A385T) combined with secretor phenotype is associated with ...
Darinnat Buathong +2 more
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Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis. [PDF]
PLoS ONE, 2017 The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-
Rieko Ajima, Emiko Suzuki, Yumiko Saga
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Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY
Nature Communications, 2023 Kumar and colleagues report cryo-EM structures of Arabidopsis O-fucosyltransferase SPINDLY in its apo and GDP-fucose bound states, revealing distinct active-site features enabling GDP-fucose recognition and surprisingly dynamic conformations that ...
Shivesh Kumar +14 more
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The Clinical Utility of Biochemical Biomarkers in Colorectal Cancer [PDF]
Middle East Journal of CancerColorectal cancer (CRC) ranks as the third most prevalent cancer worldwide and is a leading cause of cancer-related mortality. Since many colon cancers present no significant clinical symptoms, identifying new biomarkers or a set of biological indicators
Durdi Qujeq +5 more
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Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY
Nature Communications, 2022 Arabidopsis SPINDLY (SPY) is a nucleocytoplasmic protein O-fucosyltransferase. Here, the authors present a crystal structure of Arabidopsis SPY/GDP complex, reveal SPY’s substrate recognition and enzyme mechanism, and provide insights into the glycan ...
Li Zhu +5 more
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Survey and characterization of nonfunctional alleles of FUT2 in a database
Scientific Reports, 2021 The expression of ABO antigens in human saliva is regulated by the FUT2 gene, which encodes a secretor type α(1,2)fucosyltransferase. Secretors express ABO substrates in saliva and non-secretors do not. Secretor status is an object of concern, especially
Mikiko Soejima, Yoshiro Koda
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