Results 11 to 20 of about 3,115 (208)

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3-Mediated ErbB3 Fucosylation in Lung Adenocarcinoma. [PDF]

Adv Sci (Weinh)
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Chen L, Guo J, Li F, Gao M, Li R, Huang Z, Zheng Y, Gao C, Hou J, Yu Q, Zheng B, Chen X, Zhang W, Hong X, Zheng Y, Wang D, Li Q, Hu T, Zhan YY.   +18 more
europepmc   +2 more sources

Post-Synthetic Defucosylation of AGP by Aspergillus nidulans α-1,2-Fucosidase Expressed in Arabidopsis Apoplast Induces Compensatory Upregulation of α-1,2-Fucosyltransferases.

PLoS ONE, 2016
Cell walls are essential components of plant cells which perform a variety of important functions for the different cell types, tissues and organs of a plant.
Gennady V Pogorelko, Nathan T Reem, Zachary T Young, Lauran Chambers, Olga A Zabotina   +4 more
doaj   +2 more sources

Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases. [PDF]

PLoS ONE, 2008
Helicobacter pylori persistently colonizes the gastric mucosa of half the human population. It is one of the most genetically diverse bacterial organisms and subvariants are continuously emerging within an H. pylori population.
Christina Nilsson, Anna Skoglund, Anthony P Moran, Heidi Annuk, Lars Engstrand, Staffan Normark   +5 more
doaj   +2 more sources

Neuraminidase of influenza A viruses induces global desialylation of host cells via its intracellular function [PDF]

Microbiology Spectrum
The neuraminidase protein (NA) of influenza A viruses (IAVs) plays a role in the release of viruses from infected cells. NA on viral particles hydrolyzes sialylated glycans on the cell surface for viral budding.
Daiki Kobayashi, Takahiro Hiono, Norikazu Isoda, Yoshihiro Sakoda   +3 more
doaj   +2 more sources

Structure, function, and implications of fucosyltransferases in health and disease

Nature Communications
Fucosylation is a ubiquitous glycosylation event that shapes cellular communication and immunity. Catalyzed by fucosyltransferases (FUTs), this reaction encompasses diverse substrates, mechanisms, and biologic consequences. In this Review, we explore the
Mattia Ghirardello, Inmaculada Yruela, Pedro Merino, Robert Sackstein, Ignacio Sanz-Martínez, Ramón Hurtado-Guerrero   +5 more
doaj   +2 more sources

C-6-Modified 2-F-Fucose Derivatives as Inhibitors of Fucosyltransferases. [PDF]

Chembiochem
Fluorinated analogs of guanosine-diphosphate-β-L-fucose (GDP-Fuc) have received considerable attention for the development of inhibitors of fucosyltransferases (FUTs).
Liu Y, Boons GJ.
europepmc   +2 more sources

Altered O-linked glycosylation in benign and malignant meningiomas [PDF]

PeerJ
Background Changes in protein glycosylation have been reported in various diseases, including cancer; however, the consequences of altered glycosylation in meningiomas remains undefined.
Chutima Talabnin, Thanawat Trasaktaweesakul, Pitchanun Jaturutthaweechot, Pundit Asavaritikrai, Dusit Kongnawakun, Atit Silsirivanit, Norie Araki, Krajang Talabnin   +7 more
doaj   +3 more sources

The ABC type fucose operon regulated by XtrSs through CcpA contributes to Streptococcus suis survival in macrophages [PDF]

Virulence
Streptococcus suis (S. suis), an important zoonotic pathogen, poses a huge threat to the pig industry and human health. The fucose operon (FCS) is found in many bacteria that utilize host glycosylation modifications, contributing to bacterial growth and ...
Song Liang, Yumin Zhang, Shidan Zhang, Qiankun Bai, Xinming Pan, Jianan Liu, Qibing Gu, Huochun Yao, Guangjin Liu   +8 more
doaj   +2 more sources

POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma. [PDF]

Brain Behav
ABSTRACT Objective Protein O‐fucosyltransferase 1 (POFUT1) has been implicated in several malignancies, but its functional and prognostic significance in glioma remains insufficiently defined. This study evaluated whether POFUT1 expression is associated with glioma progression, patient outcome, and PI3K/AKT pathway activity.
Yang K, Ju C, Wang Y, Guo A, Yang X, Mi Y, Su Y, Wang C, Ji H.   +8 more
europepmc   +2 more sources

In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the fucosyltransferase multigene family.

PLoS ONE, 2013
Fucosylated glycans of the parasitic flatworm Schistosoma mansoni play key roles in its development and immunobiology. In the present study we used a genome-wide homology-based bioinformatics approach to search for genes that contribute to fucosylated ...
Nathan A Peterson, Tavis K Anderson, Timothy P Yoshino   +2 more
doaj   +2 more sources