Results 11 to 20 of about 2,493 (172)

Plant fucosyltransferase FUT11 distorts the sugar acceptor to catalyze via a transient oxocarbenium intermediate mechanism [PDF]

Nature Communications
Glycosyltransferases catalyze glycosidic bond formation by activating the donor sugar, while the sugar acceptor substrate is considered passive, maintaining a chair conformation during catalysis.
Víctor Taleb, Ignacio Sanz-Martínez, Sonia Serna, María Bort-Griñó, Yoshiki Narimatsu, Sanae Furukawa, Niels C. Reichardt, Henrik Clausen, Pedro Merino, Ramon Hurtado-Guerrero   +9 more
doaj   +2 more sources

Host Cell Response to Rotavirus Infection with Emphasis on Virus–Glycan Interactions, Cholesterol Metabolism, and Innate Immunity

Viruses, 2023
Although rotavirus A (RVA) is the primary cause of acute viral gastroenteritis in children and young animals, mechanisms of its replication and pathogenesis remain poorly understood.
Molly Raque, Sergei A. Raev, Yusheng Guo, Maryssa K. Kick, Linda J. Saif, Anastasia N. Vlasova   +5 more
doaj   +1 more source

Acute and chronic lung inflammation drives changes in epithelial glycans

Frontiers in Immunology, 2023
IntroductionAsthma is the most common chronic inflammatory disease and it is characterized by leukocyte infiltration and tissue remodeling, with the latter generally referring to collagen deposition and epithelial hyperplasia.
Carlos A. Alvarez, Emily Qian, Emily Qian, Leandre M. Glendenning, Kalob M. Reynero, Emily N. Kukan, Brian A. Cobb   +6 more
doaj   +1 more source

FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ihara, H, Gao, CX, Ikeda, Y, Taniguchi, N   +3 more
openaire   +2 more sources

FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway

BMC Pulmonary Medicine, 2023
Objective Fucosyltransferases (FUTs) molecules have been identified to be involved in carcinogenesis of malignant tumors. Nevertheless, the biological function of fucosyltransferases-3 (FUT3) in lung adenocarcinoma (LUAD) malignant phenotype remains ...
Lanlan Lin, Xiaohui Chen, Guofu Lin, Luyang Chen, Yuan Xu, Yiming Zeng   +5 more
doaj   +1 more source

Publisher Correction: Functional characterization of Schistosoma mansoni fucosyltransferases in Nicotiana benthamiana plants

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Kim van Noort, Dieu‑Linh Nguyen, Verena Kriechbaumer, Chris Hawes, Cornelis H. Hokke, Arjen Schots, Ruud H. P. Wilbers   +6 more
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Structural Insights in Mammalian Sialyltransferases and Fucosyltransferases: We Have Come a Long Way, but It Is Still a Long Way Down

Molecules, 2021
Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive ...
Ravneet Kaur Grewal, Abdul Rajjak Shaikh, Suresh Gorle, Manjeet Kaur, Paula Alexendra Videira, Luigi Cavallo, Mohit Chawla   +6 more
doaj   +1 more source

Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases. [PDF]

PLoS ONE, 2008
Helicobacter pylori persistently colonizes the gastric mucosa of half the human population. It is one of the most genetically diverse bacterial organisms and subvariants are continuously emerging within an H. pylori population.
Christina Nilsson, Anna Skoglund, Anthony P Moran, Heidi Annuk, Lars Engstrand, Staffan Normark   +5 more
doaj   +1 more source

An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

eLife, 2021
Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar GDP-Fuc has been ...
Giulia Bandini, Sebastian Damerow, Maria Lucia Sempaio Guther, Hongjie Guo, Angela Mehlert, Jose Carlos Paredes Franco, Stephen Beverley, Michael AJ Ferguson   +7 more
doaj   +1 more source

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Frontiers in Oncology, 2018
Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa, Lewisb, and sialyl Lewisa) and type II (H2, Lewisx, Lewisy, and sialyl Lewisx) Lewis ...
Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet   +4 more
doaj   +1 more source