Results 21 to 30 of about 2,493 (172)

Fucosyltransferases Regulated by Fusobacterium Nucleatum and Act as Novel Biomarkers in Colon Adenocarcinoma

Journal of Inflammation Research, 2023
Pengfei Wang,1,2,* Xuxu Liu,1,2,* Jingjing Yu,1,2 Ziang Meng,1,2 Zhenyi Lv,1,2 Ce Shang,1,2 Qi Geng,1,2 Dawei Wang,1,2 Dongbo Xue,1,2 Long Li3 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin ...
Wang P, Liu X, Yu J, Meng Z, Lv Z, Shang C, Geng Q, Wang D, Xue D, Li L   +9 more
doaj  

Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment [PDF]

Cytotherapy, 2014
Background aims: Advantages associated with the use of cord blood (CB) transplantation include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-versus-host disease compared with bone marrow or mobilized peripheral blood. However, poor engraftment remains a major obstacle.
Robinson, Simon N, Thomas, Michael W, Simmons, Paul J, Junjun, Lu, Yang, Hong, Parmar, Simrit, Xiaoying, Lu, Shah, Nina, Martin-Antonio, Beatriz, Bolard, Catherine, Dotti, Gianpietro, Savoldo, Barbara, Cooper, Laurence J, Najjar, Amer, Rezvani, Katayoun, Kaur, Indreshpaul, McNiece, Ian, Champlin, Richard E, Miller, Leonard P, Zweidler-Mckay, Patrick A, Shpall, Elizabeth J   +20 more
openaire   +2 more sources

Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach. [PDF]

PLoS ONE, 2012
Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required.
Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato   +13 more
doaj   +1 more source

In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the fucosyltransferase multigene family.

PLoS ONE, 2013
Fucosylated glycans of the parasitic flatworm Schistosoma mansoni play key roles in its development and immunobiology. In the present study we used a genome-wide homology-based bioinformatics approach to search for genes that contribute to fucosylated ...
Nathan A Peterson, Tavis K Anderson, Timothy P Yoshino   +2 more
doaj   +1 more source

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source

Fucosyltransferases: structure/function studies [PDF]

Glycobiology, 2001
Alpha3-fucosyltransferases (alpha3-FucTs) catalyze the final step in the synthesis of a range of important glycoconjugates that function in cell adhesion and lymphocyte recirculation. Six members of this family of enzymes have been cloned from the human genome, and their expression pattern has been shown to be highly regulated. Each enzyme has a unique
T, de Vries, R M, Knegtel, E H, Holmes, B A, Macher   +3 more
openaire   +2 more sources

Subcellular localisation of cerebral fucosyltransferase [PDF]

FEBS Letters, 1984
GDP‐fucose : asialofetuin fucosyltransferase from sheep brain was fractionated on a sucrose gradient into two activity peaks. Using purification on Ficoll adapted from the proposed method [(1980) J. Neurochem. 35, 281‐296], double localisation of cerebral fucosyltransferase was confirmed and the subcellular active fractions identified as light ...
Broquet, P., Serres-Guillaumond, M., Baubichon-Cortay, H., Peschard, Mj, Louisot, P.   +4 more
openaire   +3 more sources

Multi-omic Characterization of Protein O-Fucosyltransferases POFUT1 and POFUT2 as Novel Prognostic Biomarkers and Immune Modulators in Epithelial Ovarian Cancer

Biomedical and Biotechnology Research Journal
Background: Epithelial ovarian cancer (EOC) remains the most fatal gynecological malignancy worldwide, with 5-year survival rates of only 30%–45%. Aberrant glycosylation, especially fucosylation mediated by protein O-fucosyltransferases 1 and 2 (POFUT 1 ...
Zakir Ullah, Wang Fei, Perbhat Ali, Pei Xiaosong, Lei Yuyu, Muhammad Muddasar Saeed, Liu Shuai   +6 more
doaj   +1 more source

Advances in Biosynthesis of Fucosylated Human Milk Oligosaccharides(岩藻糖基化母乳寡糖的生物合成研究进展) [PDF]

Shipin kexue jishu xuebao
Fucosylated human milk oligosaccharides (FHMOs), mainly including 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), and difucosyllactose (DFL), are the most abundant neutral human milk oligosaccharides in breast milk.
JIANG Zhengqiang(江正强), LIANG Shanquan(梁山泉), YANG Shaoqing(杨绍青)   +2 more
doaj   +1 more source

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take

Viruses, 2020
Innate resistance to viral infections can be attributed to mutations in genes involved in the immune response, or to the receptor/ligand. A remarkable example of the latter is the recently described Mendelian trait resistance to clinically important and ...
Sumit Sharma, Marie Hagbom, Lennart Svensson, Johan Nordgren   +3 more
doaj   +1 more source