Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression [PDF]
Nature CommunicationsCore fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang +7 more
doaj +2 more sources
Genetic Diseases of Fucosylation: Insights from Model Organisms. [PDF]
Genes (Basel)Fucosylation plays a fundamental role in maintaining cellular functions and biological processes across all animals. As a form of glycosylation, it involves the biochemical addition of fucose, a six-carbon monosaccharide, to biological molecules like ...
Ameen MT, French CR.
europepmc +2 more sources
Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation [PDF]
Genes and DiseasesFucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable for many biological processes, such as ligand–receptor
Caihan Duan +4 more
doaj +2 more sources
Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases
Frontiers in ImmunologyMetabolic changes are coupled with alteration in protein glycosylation. In this review, we will focus on macrophages that are pivotal in the pathogenesis of pulmonary fibrosis and sarcoidosis and thanks to their adaptable metabolism are an attractive ...
Katarzyna Drzewicka, Zbigniew Zasłona
doaj +2 more sources
Defective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia [PDF]
Nature CommunicationsPreeclampsia (PE) is a severe pregnancy disorder caused by placental dysfunction. Protein O-fucosylation is a type of protein post translational modification that is catalyzed by protein O-fucosyltransferases (poFUTs).
Yaqi Li +7 more
doaj +2 more sources
FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ihara, H +3 more
openaire +2 more sources
Phylogenetic tree of Cardicola forsteri fucosyltransferases.
, 2022 Outgroup-rooted maximum likelihood tree of the fucosyltransferases from Cardicola forsteri (shown in red) in Table 5 with fucosyltransferases from Schistosoma mansoni and Thunnus maccoyii (as the outgroup in blue): SmFucTA (G9HW08), SmFucTB (E2EAI5 ...
Barbara F. Nowak (13961225) +5 more
core +1 more source
Expression of fucosyltransferases in control and 5H4PB-treated HaCaT cells.
, 2023 A) TPMs of fucosyltransferases expressed by the HaCaT cell line. Bar, S.D. (n = 2–3). *P® II Cell Lysis & RT Kit for qPCR (SCQ-401; Toyobo, Tokyo, Japan). Sequences of primer sets used in this study are listed below.
Yoshio Tsujino (1283079) +4 more
core +1 more source
eLife, 2021 Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar GDP-Fuc has been ...
Giulia Bandini +7 more
doaj +1 more source
Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages
IMA Fungus, 2023 Fucose is a deoxyhexose sugar present and studied in mammals. The process of fucosylation has been the primary focus in studies relating to fucose in animals due to the presence of fucose in Lewis antigens.
Małgorzata Orłowska +3 more
doaj +1 more source