Results 31 to 40 of about 3,115 (208)

A new superfamily of protein-O-fucosyltransferases,  2-fucosyltransferases, and  6-fucosyltransferases: phylogeny and identification of conserved peptide motifs [PDF]

Glycobiology, 2003
The presence of three conserved peptide motifs shared by alpha2-fucosyltransferases, alpha6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by ...
Ivan, Martinez-Duncker, Rosella, Mollicone, Jean-Jacques, Candelier, Christelle, Breton, Rafael, Oriol   +4 more
openaire   +2 more sources

Alpha-L-fucosyltransferases in human submaxillary gland and stomach tissues associated with the H, Lea and Leb blood-group characters and ABH secretor status

, 1969
Schemes for the biosynthetic steps in the formation of the blood group active glycoproteins in secretions postulate that α-Image -fucosyltransferases specified by the Image and Image genes control the addition of Image -fucose to different acceptor sites
Watkins, Winifred M, Chester, Alan, Chester, Alan,, Lund University.   +3 more
core   +2 more sources

Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment [PDF]

Cytotherapy, 2014
Background aims: Advantages associated with the use of cord blood (CB) transplantation include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-versus-host disease compared with bone marrow or mobilized peripheral blood. However, poor engraftment remains a major obstacle.
Robinson, Simon N, Thomas, Michael W, Simmons, Paul J, Junjun, Lu, Yang, Hong, Parmar, Simrit, Xiaoying, Lu, Shah, Nina, Martin-Antonio, Beatriz, Bolard, Catherine, Dotti, Gianpietro, Savoldo, Barbara, Cooper, Laurence J, Najjar, Amer, Rezvani, Katayoun, Kaur, Indreshpaul, McNiece, Ian, Champlin, Richard E, Miller, Leonard P, Zweidler-Mckay, Patrick A, Shpall, Elizabeth J   +20 more
openaire   +2 more sources

Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach. [PDF]

PLoS ONE, 2012
Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required.
Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato   +13 more
doaj   +1 more source

Subcellular localisation of cerebral fucosyltransferase [PDF]

FEBS Letters, 1984
GDP‐fucose : asialofetuin fucosyltransferase from sheep brain was fractionated on a sucrose gradient into two activity peaks. Using purification on Ficoll adapted from the proposed method [(1980) J. Neurochem. 35, 281‐296], double localisation of cerebral fucosyltransferase was confirmed and the subcellular active fractions identified as light ...
Broquet, P., Serres-Guillaumond, M., Baubichon-Cortay, H., Peschard, Mj, Louisot, P.   +4 more
openaire   +3 more sources

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source

Fucosyltransferases: structure/function studies [PDF]

Glycobiology, 2001
Alpha3-fucosyltransferases (alpha3-FucTs) catalyze the final step in the synthesis of a range of important glycoconjugates that function in cell adhesion and lymphocyte recirculation. Six members of this family of enzymes have been cloned from the human genome, and their expression pattern has been shown to be highly regulated. Each enzyme has a unique
T, de Vries, R M, Knegtel, E H, Holmes, B A, Macher   +3 more
openaire   +2 more sources

Multi-omic Characterization of Protein O-Fucosyltransferases POFUT1 and POFUT2 as Novel Prognostic Biomarkers and Immune Modulators in Epithelial Ovarian Cancer

Biomedical and Biotechnology Research Journal
Background: Epithelial ovarian cancer (EOC) remains the most fatal gynecological malignancy worldwide, with 5-year survival rates of only 30%–45%. Aberrant glycosylation, especially fucosylation mediated by protein O-fucosyltransferases 1 and 2 (POFUT 1 ...
Zakir Ullah, Wang Fei, Perbhat Ali, Pei Xiaosong, Lei Yuyu, Muhammad Muddasar Saeed, Liu Shuai   +6 more
doaj   +1 more source

Advances in Biosynthesis of Fucosylated Human Milk Oligosaccharides(岩藻糖基化母乳寡糖的生物合成研究进展) [PDF]

Shipin kexue jishu xuebao
Fucosylated human milk oligosaccharides (FHMOs), mainly including 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), and difucosyllactose (DFL), are the most abundant neutral human milk oligosaccharides in breast milk.
JIANG Zhengqiang(江正强), LIANG Shanquan(梁山泉), YANG Shaoqing(杨绍青)   +2 more
doaj   +1 more source

The Presence of Fucosyltransferases with Different Substrate Specificity in Human Parotid Saliva

, 1983
Using glycoproteins and milk oligosaccharides as substrate acceptors, we demonstrated at leaet two fucosyltransferases in human parotid saliva. One enzyme transferred L-fucose from GDP-fucose to the C-3 position of N-acetylglucosamine or glucose residue
H. Tamagawa, E. Inoshita, S. Shizukuishi, S. Shibata, A. Tsunemitsu   +4 more
core   +1 more source