Results 31 to 40 of about 91,025 (255)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Fundamental study of perfluoro oil degradative treatment by subcritical water reaction and design of bench-scale equipment

Mechanical Engineering Journal
Various types of machine oil are used for analysis and utility equipment, and these organic liquid wastes are stored in nuclear facilities and laboratories due to a lack of appropriate treatment processes.
Tomomasa FUNAKOSHI, Sou WATANABE, Yoichi ARAI, Toshihiro IWAMOTO, Masayuki WATANABE, Yoshihiro NISHIMOTO, Makoto YASUDA   +6 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Characterization of spent nuclear fuel canister surface roughness using surface replicating molds

Scientific Reports
In this study we present a replication method to determine surface roughness and to identify surface features when a sample cannot be directly analyzed by conventional techniques.
B. L. Nation, J. L. Faubel, G.T. Vice, J. A. Ohlhausen, S. Durbin, C. R. Bryan, A. W. Knight   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Numerical investigation of thermal-hydraulic performance enhancement in helical coil heat exchangers with twisted tube geometries

Case Studies in Thermal Engineering
This numerical study examines the thermal-hydraulic performance of helical coil heat exchangers (HCHEs) using twisted tubes versus conventional circular tubes.
Valiyollah Ghazanfari, Mohammad Mahdi Shadman, Fatemeh Mansourzade, Younes Amini   +3 more
doaj   +1 more source

Comprehensive Uncertainty Quantification in Nuclear Safeguards

Science and Technology of Nuclear Installations, 2017
Nuclear safeguards aim to confirm that nuclear materials and activities are used for peaceful purposes. To ensure that States are honoring their safeguards obligations, quantitative conclusions regarding nuclear material inventories and transfers are ...
E. Bonner, T. Burr, T. Krieger, K. Martin, C. Norman   +4 more
doaj   +1 more source

Geochemistry of Uranium and Rare Earth Elements in the Phosphate Horizon of Jeiroud Formation, Firoozkuh area, Central Alborz Zone [PDF]

مجله علوم و فنون هسته‌ای
Two phosphorite deposits including Paghela and Gadok, within the Jiroud Formation (Upper Devonian) in the northeast of Firoozkuh in the Central Alborz geotectonic zone have been studied.
Samaneh Ziapour, Khalegh Khoshnoodi
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source