Results 41 to 50 of about 3,188,407 (297)

Stability of Tungsten Crucible against Uranium, Rare Earth, Cadmium, and Chlorides for Cathode Process in Pyroprocessing

Science and Technology of Nuclear Installations, 2019
The stability of W against U, rare-earth (RE) elements, Cd, and various chlorides was evaluated by melting and distillation testing. Three runs were performed with a W crucible to examine its reactivity: (i) RE melting by induction heating, (ii) salt ...
Junhyuk Jang, Seungyoub Han, Tack-Jin Kim, Gha-Young Kim, Chang Hwa Lee, Sung-Jai Lee   +5 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fundamental study of perfluoro oil degradative treatment by subcritical water reaction and design of bench-scale equipment

Mechanical Engineering Journal
Various types of machine oil are used for analysis and utility equipment, and these organic liquid wastes are stored in nuclear facilities and laboratories due to a lack of appropriate treatment processes.
Tomomasa FUNAKOSHI, Sou WATANABE, Yoichi ARAI, Toshihiro IWAMOTO, Masayuki WATANABE, Yoshihiro NISHIMOTO, Makoto YASUDA   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Characterization of spent nuclear fuel canister surface roughness using surface replicating molds

Scientific Reports
In this study we present a replication method to determine surface roughness and to identify surface features when a sample cannot be directly analyzed by conventional techniques.
B. L. Nation, J. L. Faubel, G.T. Vice, J. A. Ohlhausen, S. Durbin, C. R. Bryan, A. W. Knight   +6 more
doaj   +1 more source

Geochemistry of Uranium and Rare Earth Elements in the Phosphate Horizon of Jeiroud Formation, Firoozkuh area, Central Alborz Zone [PDF]

مجله علوم و فنون هسته‌ای
Two phosphorite deposits including Paghela and Gadok, within the Jiroud Formation (Upper Devonian) in the northeast of Firoozkuh in the Central Alborz geotectonic zone have been studied.
Samaneh Ziapour, Khalegh Khoshnoodi
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Comprehensive Uncertainty Quantification in Nuclear Safeguards

Science and Technology of Nuclear Installations, 2017
Nuclear safeguards aim to confirm that nuclear materials and activities are used for peaceful purposes. To ensure that States are honoring their safeguards obligations, quantitative conclusions regarding nuclear material inventories and transfers are ...
E. Bonner, T. Burr, T. Krieger, K. Martin, C. Norman   +4 more
doaj   +1 more source