Results 41 to 50 of about 10,509 (217)

DEBRIS-FRETTING TEST OF COATED AND UNCOATED ZR-1%NB CLADDING

Acta Polytechnica CTU Proceedings, 2019
Debris fretting is one of the most significant fuel rod failure causes. An approach to mitigate this is to apply special coatings on the surface of the cladding that are supposed to increase the wear resistance.
Marcin Kopeć, Martina Malá, Ladislav Cvrček, Jakub Krejčí   +3 more
doaj   +1 more source

Optimization of Space Debris Collision Avoidance Maneuver for Formation Flying Satellites [PDF]

Journal of Astronomy and Space Sciences, 2013
The concept of the satellite formation flight is area where it is actively study with expandability and safety compare to existing satellite. For execution of duty with more safety issue, it needs to consider hot topic of space debris for operation of ...
Jae-Dong Seong, Hae-Dong Kim
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

NUMERICAL SIMULATION FOR LARGE UNCONTAINED ENGINE DEBRIS IMPACT AND PROTECTION METHODS

Jixie qiangdu, 2016
In order to evaluate the impact process induced by uncontained failure,numerical simulation for one-third HPT（ High Pressure Turbine） disk impact was carried out under different obliquity angles and residual fuel volumes in the wing structure.
LI KeJun, PEI Yang, SONG BiFeng, YI HuaHui   +3 more
doaj  

The volume and composition of dead wood on traditional and forest fuel harvested clear-cuts

Silva Fennica, 2010
Logging residue and cut stumps are increasingly used as a renewable energy source known as forest fuel. Forest fuel harvesting obviously reduces the volume of dead wood and is likely to alter the dead wood composition, but the magnitude of the change ...
Eräjää, Sini, Halme, Panu, Kotiaho, Janne, Markkanen, Anni, Toivanen, Tero   +4 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Chemical analysis of fire debris in atypical fire incidents

Forensic Science International: Reports
In atypical fire cases where ignitable liquid residues were undetected using traditional fire debris detection methods, analyzing other chemical traces such as the gaseous and volatile organic contents, and liquid and solid components of the debris ...
Kang Hua Lee, Thiam Bon Lim
doaj   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source