Results 91 to 100 of about 238,061 (301)

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

On computation of solid fuel regression rate in ramjet combustor

Journal of Physics: Conference Series, 2017
Development of a solid fuel ramjets requires mathematical modeling of the solid fuel regression inside a combustor with accounting of solid fuel gasification and combustion processes and a numerical method to calculate parameters of these processes. This report presents a quasi-one-dimensional model of processes inside the solid fuel ramjet combustor ...
A V Razmyslov, L S Yanovskiy, P D Toktaliev   +2 more
openaire   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

3D printed different polymer fuel grains for hybrid rocket engine

FirePhysChem
The advent of various additive manufacturing technologies, such as 3D printing, has changed the structural design and preparation process of rocket fuels.
Xiaodong Yu, Hongsheng Yu, Hongwei Gao, Wei Zhang, Luigi T. DeLuca, Ruiqi Shen   +5 more
doaj   +1 more source

Hybrid propulsion technology program: Phase 1. Volume 3: Thiokol Corporation Space Operations [PDF]

Three candidate hybrid propulsion (HP) concepts were identified, optimized, evaluated, and refined through an iterative process that continually forced improvement to the systems with respect to safety, reliability, cost, and performance criteria. A full
Schuler, A. L., Wiley, D. R.
core   +1 more source

Unjuk Kerja Motor Suzuki Smash 110 Cc Dengan Bahan Bakar Kombinasi Brown Gas Dan Bensin [PDF]

, 2012
One of the alternative fuel mixture that can be used by the gasoline motor is Brown\u27s Gas. The gas is produced from the electrolysis solution of baking soda inside the elektrolizer. Percentage of baking soda solution is 99.45% destilled water and 0.55%
Gede, I. N. (I), Gunawan, H. (Hardi), Rantung, A. A. (Arther)   +2 more
core   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Enhancement of the energetic performance of solid fuels with metal-fluoropolymer additives

FirePhysChem
Aluminum (Al) holds a pivotal role in augmenting the energetic potential of solid fuel formulations. Its incorporation can notably amplify the energy yield upon combustion.
Ayush Koul, Aparna Ojha, Prenav Vimal, Yash Pal, Sri Nithya Mahottamananda, Subha S, Djalal Trache   +6 more
doaj   +1 more source