Results 91 to 100 of about 11,216,273 (301)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A full scale bicycle aerodynamics testing methodology

, 2011
Aerodynamically efficient sport equipment/accessories and athlete's body postures are considered to be the fundamental aspect to achieving better outcomes. Like any other speed sports, the aerodynamic optimization is essential in cycling. A standard full
Md Abdullah Al Harun Khan Chowdhury (18035152), Firoz Alam (18026107), David Mainwaring (19974711)   +2 more
core  

Destructive testing and failure analysis of a full-scale composite tidal turbine blade

International Marine Energy Journal
Tidal stream turbines play a pivotal role in harnessing marine energy, yet their reliability remains a critical challenge, impeding the cost-effectiveness of tidal energy.
Fergus Cuthill, Sergio Lopez Dubon, Christopher Vogel, Miguel Valdivia Camacho, Conchúr Ó Brádaigh, Eddie McCarthy   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Full-Scale Testing of the Float Dust Deposition Meter [PDF]

Full-scale testing and results are described for an automated system that continuously monitors the accumulation of coal dust in mine ...

core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Compressive strength capacity of light gauge steel composite columns

Case Studies in Construction Materials, 2016
The axial compressive strength capacity of concrete-filled light gauge steel composite columns was assessed through an experimental program involving twelve long and fourteen stub columns with width-to-thickness ratio of 125 for the encasing steel ...
W. Leonardo Cortés-Puentes, Dan Palermo, Alaa Abdulridha, Muslim Majeed   +3 more
doaj   +1 more source

Full-scale tests of deicing with seawater

Cold Regions Science and Technology
Sea-spray icing is one of the major hazards for small- and medium-sized vessels in polar regions. Predominant anti- and deicing measures include prevention by heeding the weather forecasts and avoiding high-risk situations, protection by enclosing exposed and high-priority areas, manual ice removal by personnel, heat tracing and surplus heat. Energy is
Sæterdal, Ane Solbakken, Sundsbø, Per-Arne   +1 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source