Results 81 to 90 of about 2,779,069 (311)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Journal of the South African Institution of Civil Engineers, 2011 This paper presents the response of a full-scale dry-stack masonry structure subject to earthquake loads. The following earthquakes were applied to the base of the structure: (a) North Ridge, (b) Llolleo, (c) El Centro and (d) Llolleo for the second time.
A Elvin, H C Uzoegbo
doaj
Brazed Borsic/aluminum structural panels [PDF]
A fluxless brazing process has been developed that minimizes degradation of the mechanical properties of Borsic/aluminum composites. The process, which employs 718 aluminum alloy braze, is being used to fabricate full scale Borsic/aluminum-titanium ...
Bales, T. T. +2 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
IMEX evolution of scalar fields on curved backgrounds [PDF]
, 2009 Inspiral of binary black holes occurs over a time-scale of many orbits, far longer than the dynamical time-scale of the individual black holes. Explicit evolutions of a binary system therefore require excessively many time steps to capture interesting ...
Hesthaven, Jan S. +2 more
core +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Icing testing in the large Modane wind-tunnel on full-scale and reduced scale models [PDF]
Icing tests on full scale models of parts of aircraft (wings, tailplanes, radome) equipped with actual de-icing systems were carried out in the large Modane wind tunnel of ONERA.
Charpin, F., Fasso, G.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Destructive testing and failure analysis of a full-scale composite tidal turbine blade
International Marine Energy JournalTidal stream turbines play a pivotal role in harnessing marine energy, yet their reliability remains a critical challenge, impeding the cost-effectiveness of tidal energy.
Fergus Cuthill +5 more
doaj +1 more source