Results 141 to 150 of about 2,779,069 (311)
Outer planets probe testing [PDF]
An atmospheric entry Probe is being developed by NASA Ames Research Center (ARC) to conduct in situ scientific investigations of the outer planets' atmospheres.
Edwards, T. M. +2 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Full-Scale Testing of Wood Structures
, 1980 Testing full-scale structures is a means to understanding how completed structures perform. Unfortunately, few guidelines exist to aid engineers engaged in such evaluation. Many test procedures are equally applicable to complete structures regardless of the construction material.
openaire +2 more sources
Regenerative CO2 removal for PLSS application [PDF]
Various concepts for the design of the nonelectrochemical absorber were defined and evaluated. A preliminary design based on the use of hollow fiber membranes was developed. Small scale bench testing demonstrated the carbon dioxide removal capability and
Heppner, D. B. +2 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Hot-bench simulation of the active flexible wing wind-tunnel model [PDF]
Two simulations, one batch and one real-time, of an aeroelastically-scaled wind-tunnel model were developed. The wind-tunnel model was a full-span, free-to-roll model of an advanced fighter concept.
Buttrill, Carey S., Houck, Jacob A.
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Helicopter transmission testing at NASA Lewis Research Center [PDF]
The helicopter has evolved into a highly valuable air mobile vehicle for both military and civilian needs. The helicopter transmission requires advanced studies to develop a technology base for future rotorcraft advances.
Coy, John J., Lewicki, David G.
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source