Results 121 to 130 of about 14,477,800 (285)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Self-concept consistency and short-term stability in eight cultures [PDF]

, 2012
Self-concept consistency and short-term stability were investigated in the United States, Australia, Mexico, Venezuela, Philippines, Malaysia, China, and Japan. Evidence for substantial cross-role consistency and reliable within-individual variability in
Ching, C.M., Tanaka-Matsumi, J., Mastor, K.A., Zhang, H.S., Curtis, G.J., Buchanan, A.L., Ibáñez-Reyes, J., Vargas-Flores, J.d.J., Church, T.A., Katigbak, M.S., Shen, J., Simon, J.Y.R., Locke, K.D., Alvarez, J.M., Ortiz, F.A., Cabrera, H.F.   +15 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Local and Global Consistency Properties for Student Placement [PDF]

In the context of resource allocation on the basis of priorities, Ergin (2002) identifies a necessary and sufficient condition on the priority structure such that the student-optimal stable mechanism satisfies a consistency principle.
Bettina Klaus, Flip Klijn
core  

Diverse Humanoid Robot Pose Estimation from Images Using Only Sparse Datasets

Applied Sciences
We present a novel dataset for humanoid robot pose estimation from images, addressing the critical need for accurate pose estimation to enhance human–robot interaction in extended reality (XR) applications.
Seokhyeon Heo, Youngdae Cho, Jeongwoo Park, Seokhyun Cho, Ziya Tsoy, Hwasup Lim, Youngwoon Cha   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Consistency and robustness of kernel based regression [PDF]

We investigate properties of kernel based regression (KBR) methods which are inspired by the convex risk minimization method of support vector machines.
Christmann, Andreas, Steinwart, Ingo
core  

A Note on How to Extend Gentzen’s Second Consistency Proof to a Proof of Normalization for First Order Arithmetic

, 2015
The purpose of this note is to show that the normalization theorem can be proved for first order Peano arithmetic by adapting to natural deduction the method used in Gentzen’s second consistency proof.
Dag Prawitz, Prawitz, Dag,
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source