Results 111 to 120 of about 64,833 (294)

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Physical layer security performance analysis of multi-antenna full-duplex relay aided heterogeneous cellular network

Tongxin xuebao, 2019
To alleviate the spectrum shortage problem and security threats in heterogeneous network (HetNet),multi-antenna full-duplex relay was introduced for communication between femto base station (FBS) and legitimate user.With the aid of multi-antenna full ...
Zhou ZHONG, Bo ZHANG, Xiaohui QI, Kaizhi HUANG   +3 more
doaj   +2 more sources

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Two closely spaced microstrip patches with high isolation for full-duplex/MIMO applications. [PDF]

PLoS One, 2023
Tran HH, Nguyen TT, Nguyen Thi T.
europepmc   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

Optimizing Cellular Network Binary Rate and Fairness: Examination of a Two-Tier Hybrid Duplex Architecture Employing Full-Duplex and Half-Duplex Modes

IEEE Access
Full-duplex HCNs have emerged as a compelling solution to meet the escalating traffic demands of future fifth-generation networks. Theoretical advantages of full-duplex cellular networks include the potential for doubling throughput compared to half ...
Muhammad Mujtaba Shaikh, Safia Amir Dahri, Khursheed Aurangzeb, Muhammad Afzal Soomro, Musaed Alhussein, Bharat Bhushan   +5 more
doaj   +1 more source

Half-duplex and full-duplex interference mitigation in relays assisted heterogeneous network. [PDF]

PLoS One, 2023
Madani Fadoul M, Chow CO.
europepmc   +1 more source

MIMO Full-Duplex ?????? ??????

, 2015
In this paper, a multi-input multi-output (MIMO) full-duplex system is addressed, where both the transmitter and receiver have multiple antennas. Fundamental problems of the MIMO full-duplex technique are discussed, and possible solutions are presented ...
Yang, Hyun Jong
core  

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source