Results 121 to 130 of about 2,971,228 (370)
Advanced Science, EarlyView.Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han +6 more
wiley +1 more source
Reconfigurable Intelligent Surfaces for Energy Efficiency in Full-duplex Communication System [PDF]
, 2022 Yiru Wang +3 more
openalex +1 more source
Advanced Science, EarlyView.Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go +12 more
wiley +1 more source
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
Passive Self-Interference Suppression for Full-Duplex Infrastructure Nodes [PDF]
, 2014 Evan Everett +2 more
openalex +1 more source
Full Duplex and Wireless-Powered Communications
, 2020 Wireless energy transfer (WET) is an attractive energy-efficient technology that has been identified as a potential enabler for the Internet of Things (IoT) era. Recently, there is an increasing interest in combining full duplex (FD) and WET to achieve greater system performance, and in this chapter we overview the main characteristics of the wireless ...
Alves Hirley, Alcaraz López Onel
openaire +2 more sources
Advanced Science, EarlyView.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
Full-duplex device-to-device communications:key technologies and prospects
Dianxin kexue, 2018 Due to the physical proximity,D2D communications can bring proximity gain,reusing gain and hop gain,and thus can potentially increase system spectral-efficiency and energy-efficiency.Full-duplex D2D communications,which enable the transceiver to ...
Jiaxin DING +3 more
doaj +2 more sources
Improving the Security and Spectrum Efficiency in Overlay Cognitive Full-Duplex Wireless Networks [PDF]
, 2019 Mu Li +4 more
openalex +1 more source