Results 61 to 70 of about 4,551,617 (315)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Rotorcraft research testing in the National Full-Scale Aerodynamics Complex at NASA Ames Research Center [PDF]
The unique capabilities of the National Full-Scale Aerodynamics Complex (NFAC) for testing rotorcraft systems are described. The test facilities include the 40- by 80-Foot Wind Tunnel, the 80- by 120-Foot Wind Tunnel, and the Outdoor Aerodynamic Research
Johnson, W., Smith, C. A., Warmbrodt, W.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Journal of Marine Science and Engineering, 2019 Spectral fatigue analysis is performed on the trimaran cross-deck structural detail. A global finite element (FE) model with local fine meshes at hot spot locations is built for the calculation of structural response.
Chunbo Zhen +3 more
doaj +1 more source
Full scale fatigue testing of crankshaft
Rakenteiden Mekaniikka, 2017 This article outlines full-scale fatigue testing of crankshafts, in particular with the resonance fatigue testing method. The focus of the paper is the practical implementation of the method.
Korhonen, Jussi +3 more
openaire +3 more sources
Analysis of small-scale rotor hover performance data [PDF]
Rotor hover-performance data from a 1/6-scale helicopter rotor are analyzed and the data sets compared for the effects of ambient wind, test stand configuration, differing test facilities, and scaling. The data are also compared to full scale hover data.
Kitaplioglu, Cahit
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
DC-10 composite vertical stabilizer ground test program [PDF]
A review of the structural configuration and ground test program is presented. Particular emphasis is placed on the testing of a full-scale stub box test subcomponent and full span ground test unit.
Palmer, J. M., Jr. +2 more
core +1 more source
Experimental Test bed to De-Risk the Navy Advanced Development Model [PDF]
, 2017 This paper presents a reduced scale demonstration test-bed at the University of Texas’ Center for Electromechanics (UT-CEM) which is well equipped to support the development and assessment of the anticipated Navy Advanced Development Model (ADM).
Feng, X +6 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source