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Clinicogenomic Landscape and Function of <i>PIK3CA</i>, <i>AKT1</i>, and <i>PTEN</i> Mutations in Breast Cancer. [PDF]
JCO Precis OncolTao JJ +7 more
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Drugs, 2001
Fulvestrant is a 7alpha-alkylsulphinyl analogue of estradiol that competes with endogenous estrogen for binding to the estrogen receptor. Once bound to the receptor, fulvestrant attenuates receptor dimerisation, effecting a rapid degradation of the estrogen receptor protein and inhibition of transcription.
M, Curran, L, Wiseman
+6 more sources
Fulvestrant is a 7alpha-alkylsulphinyl analogue of estradiol that competes with endogenous estrogen for binding to the estrogen receptor. Once bound to the receptor, fulvestrant attenuates receptor dimerisation, effecting a rapid degradation of the estrogen receptor protein and inhibition of transcription.
M, Curran, L, Wiseman
+6 more sources
Expert Opinion on Investigational Drugs, 2002
Fulvestrant, a novel oestrogen receptor (ER) downregulator, is a pure anti-oestrogen which completely blocks the trophic actions of oestrogens without exerting any partial agonist effects. It reduces expression of oestrogen receptor, progesterone receptor and proliferative and cell turnover indices. The drug is well-tolerated with minimal systemic side
Kwok Leung, Cheung, John F R, Robertson
openaire +2 more sources
Fulvestrant, a novel oestrogen receptor (ER) downregulator, is a pure anti-oestrogen which completely blocks the trophic actions of oestrogens without exerting any partial agonist effects. It reduces expression of oestrogen receptor, progesterone receptor and proliferative and cell turnover indices. The drug is well-tolerated with minimal systemic side
Kwok Leung, Cheung, John F R, Robertson
openaire +2 more sources
Hospital Pharmacy, 2002
The increasing complexity of cancer chemotherapy makes it mandatory that pharmacists be familiar with these highly toxic agents. This column focuses on the commercially available and investigational agents used to treat malignant diseases, reviewing issues related to the preparation, dispensing, and administration of cancer chemotherapy.
Dominic A. Solimando, J. Aubrey Waddell
openaire +1 more source
The increasing complexity of cancer chemotherapy makes it mandatory that pharmacists be familiar with these highly toxic agents. This column focuses on the commercially available and investigational agents used to treat malignant diseases, reviewing issues related to the preparation, dispensing, and administration of cancer chemotherapy.
Dominic A. Solimando, J. Aubrey Waddell
openaire +1 more source
DMW - Deutsche Medizinische Wochenschrift, 2006
S, Roth, S, Schaad, V, Hardel, U, Jaehde
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S, Roth, S, Schaad, V, Hardel, U, Jaehde
openaire +2 more sources