Enhanced Fumagillin Production by Optimizing Fermentation and Purification Techniques
FermentationFumagillin is a complex biomolecule. Nowadays, the separation and purification techniques of fumagillin still need to be optimized. In this study, the yield of fumagillin was examined in relation to temperature, pH, inoculation volume, rotation speed ...
Zili Feng +5 more
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Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition [PDF]
, 2007 The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation, and as such provides a valuable target in both inflammation and cancer. Rheumatoid arthritis (RA) is a chronic inflammatory
David Essex +5 more
core +3 more sources
Frontiers in Veterinary Science, 2019 Honey bees (Apis mellifera) are agriculturally important pollinators that have been recently at risk to severe colony losses. A variety of parasites and pathogens have been linked to colony decline, including the microsporidian parasite Nosema ceranae ...
Andre J. Burnham
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Recent Advances in the Biocontrol of Nosemosis in Honey Bees (Apis mellifera L.)
Journal of Fungi, 2022 Nosemosis is a disease triggered by the single-celled spore-forming fungi Nosema apis and Nosema ceranae, which can cause extensive colony losses in honey bees (Apis mellifera L.). Fumagillin is an effective antibiotic treatment to control nosemosis, but
Massimo Iorizzo +7 more
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Penicillium arizonense, a new, genome sequenced fungal species, reveals a high chemical diversity in secreted metabolites [PDF]
, 2016 A new soil-borne species belonging to the Penicillium section Canescentia is described, Penicillium arizonense sp. nov. (type strain CBS 141311(T) = IBT 12289(T)). The genome was sequenced and assembled into 33.7 Mb containing 12,502 predicted genes.
Frisvad, J. C. +6 more
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A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus
Virulence, 2018 Virulence mechanisms of the pathogenic fungus Aspergillus fumigatus are multifactorial and depend on the immune state of the host, but little is known about the fungal mechanism that develops during the process of lung invasion. In this study, microarray
Xabier Guruceaga +13 more
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RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus. [PDF]
, 2014 BACKGROUND: Aspergillus fumigatus produces a number of secondary metabolites, one of which, gliotoxin, has been shown to exhibit anti-fungal activity. Thus, A. fumigatus must be able to protect itself against gliotoxin.
Doyle, S +6 more
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Heliyon, 2020 Unusually high wintering losses of Apis mellifera in recent years has raised concerns regarding the well-being and productivity of honey bees across the globe.
J. Reilly Comper, Hermann J. Eberl
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mBio, 2022 Fungal secondary metabolites with antibiotic activities can promote fungal adaptation to diverse environments. Besides the global regulator, individual biosynthetic gene clusters (BGCs) usually contain a pathway-specific transcription factor for the ...
Yanlei Sun +4 more
doaj +1 more source
Local inhibition of angiogenesis results in an atrophic non-union in a rat osteotomy model [PDF]
European Cells & Materials, 2011 Long bone and in particular tibia fractures frequently fail to heal. A disturbed revascularisation is supposed to be a major cause for impaired bone healing or the development of non-unions.
M Fassbender +5 more
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