Results 61 to 70 of about 2,350 (205)

Late treatment with fumagillin inhibits RV cardiomyocyte hypertrophy.

, 2012
Rats were injected with MCT and treated with fumagillin or vehicle control beginning at 14 d after MCT injury as described in Materials and Methods.
Revathi Rajkumar (173127), Daniel J. Kass (173086), Mark Markowski (173112), Asaf Savir (173105), Hunter C. Champion (173140), Liyang Yu (173100), Rehan Kahloon (173093), Eileen Rattigan (173090), Katrina Loh (173096), Ferhaan Ahmad (173134), Anjali Saqi (173119)   +10 more
core   +1 more source

Cytotoxicity and Antiparasitic Effects of Toltrazuril Against Enteromyxum leei in Olive Flounders: In Vitro and In Vivo Analyses

Journal of Fish Diseases, Volume 48, Issue 11, November 2025.
ABSTRACT The parasite Enteromyxum leei causes serious emaciation disease in marine fish species. Toltrazuril exhibits antiparasitic effects; however, the simultaneous impacts of toltrazuril on parasites and hosts are unclear. Here, we evaluate the cytotoxicity of three commercial toltrazuril products (A, B and C) and the treatment efficacy against E ...
Young Juhn Lee, Yeong Eun Oh, Eung Jun Lee, Lyu Jin Jun, Joon Bum Jeong   +4 more
wiley   +1 more source

Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins. [PDF]

PLoS ONE, 2013
Hundreds of eukaryotic signaling proteins require myristoylation to functionally associate with intracellular membranes. N-myristoyl transferases (NMT) responsible for this modification are established drug targets in cancer and infectious diseases. Here
Arafath Kaja Najumudeen, Monika Köhnke, Maja Solman, Kirill Alexandrov, Daniel Abankwa   +4 more
doaj   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Matrix-induced sugaring-out liquid–liquid extraction for the determination of fumagillin and dicyclohexylamine residues in honey by LC–MS/MS

Discover Food
The dicyclohexylamine salt of fumagillin is currently used in some countries to control nosema disease in honey bee colonies. Chemical residues in honey resulting from the use of chemotherapies in apiculture are a food safety concern.
Thomas S. Thompson, Johan P. van den Heever, Melissa J. Zarft   +2 more
doaj   +1 more source

A Case of Disseminated Encephalitozoon cuniculi in a Lung Transplant Recipient: Microsporidiosis in the Era of Molecular Diagnostics

Transplant Infectious Disease, EarlyView.
Lee S. Gottesdiener, Clare DeLaurentis, Marcus R. Pereira   +2 more
wiley   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source

Vairimorpha (Nosema) ceranae (Opisthosporidia: Microsporidia) in vitro Infection of Sf9 Insect Cell Line as an Experimental Model of Parasite – Host Interrelations

BIO Web of Conferences, 2020
Microsporidia Vairimorpha (Nosema) ceranae is an emergent parasite of honeybee Apis mellifera and has a great concern to apiculture due to high pathogenesity and fumagillin resistance.
Senderskiy Igor, Ignatieva Anastasiya, Dolgikh Viacheslav   +2 more
doaj   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications [PDF]

, 2019
Fumagillin is a mycotoxin produced, above all, by the saprophytic filamentous fungus Aspergillus fumigatus. This mold is an opportunistic pathogen that can cause invasive aspergillosis, a disease that has high mortality rates linked to it. Its ability to
Rementeria Ruiz, Aitor Domingo, Oskar Gonzalez, Ana Abad-Diaz de Cerio, Abad Díaz de Cerio, Ana, Hernando Echevarria, Fernando Luis, Uxue Perez-Cuesta, Aitor Rementeria, Pérez Cuesta, Uxue, Ramírez García, Andoni, Alonso Rojas, Rosa María, Rosa M. Alonso, Guruceaga Sierra, Xabier, Xabier Guruceaga, Fernando Luis Hernando, González Mendia, Oscar, Andoni Ramirez-Garcia   +15 more
core   +1 more source