Characterization of the Active Site and Insight into the Binding Mode of the Anti-angiogenesis Agent Fumagillin to the Manganese(II)-Loaded Methionyl Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]
, 2005 EPR spectra were recorded for methionine aminopeptidase from Escherichia coli (EcMetAP-I) samples (~2.5 mM) to which one and two equivalents of Mn(II) were added (the latter is referred to as [MnMn(EcMetAP-I)]).
Bennett, Brian +3 more
core +1 more source
Photoacoustic molecular imaging of angiogenesis using theranostic α_νβ_3-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug [PDF]
, 2014 Photoacoustic (PA) tomography imaging is an emerging, versatile, and noninvasive imaging modality, which combines the advantages of both optical imaging and ultrasound imaging.
Allen, John S. +7 more
core +1 more source
Immune priming of honey bees protects against a major microsporidian pathogen
Pest Management Science, Volume 81, Issue 12, Page 7939-7949, December 2025.We immune‐primed honey bees at two developmental stages in the laboratory and the field with heat‐killed Nosema ceranae spores. When subsequently fed live spores, immune‐primed adults had lower infection levels. Abstract BACKGROUND Honey bees face significant threats from pathogens like Nosema ceranae, a microsporidian parasite that contributes to ...
James C. Nieh +6 more
wiley +1 more source
Identification of candidate agents active against N. ceranae infection in honey bees: establishment of a medium throughput screening assay based on N. ceranae infected cultured cells. [PDF]
PLoS ONE, 2015 Many flowering plants in both natural ecosytems and agriculture are dependent on insect pollination for fruit set and seed production. Managed honey bees (Apis mellifera) and wild bees are key pollinators providing this indispensable eco- and agrosystem ...
Sebastian Gisder, Elke Genersch
doaj +1 more source
Proteasome Inhibition Is an Effective Treatment Strategy for Microsporidia Infection in Honey Bees
Biomolecules, 2021 The microsporidia Nosema ceranae is an obligate intracellular parasite that causes honey bee mortality and contributes to colony collapse. Fumagillin is presently the only pharmacological control for N. ceranae infections in honey bees.
Emily M. Huntsman +5 more
doaj +1 more source
Remodelling of the natural product fumagillol employing a reaction discovery approach [PDF]
, 2011 In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural products can be regarded as intriguing starting points
Balthaser, Bradley R. +4 more
core +1 more source
Deciphering the Anti-Aflatoxinogenic Properties of Eugenol Using a Large-Scale q-PCR Approach [PDF]
, 2016 Produced by several species of Aspergillus, Aflatoxin B1 (AFB1) is a carcinogenic mycotoxin contaminating many crops worldwide. The utilization of fungicides is currently one of the most common methods; nevertheless, their use is not environmentally or ...
Atoui, Ali +9 more
core +3 more sources
Journal of Fish Diseases, Volume 48, Issue 11, November 2025.ABSTRACT The parasite Enteromyxum leei causes serious emaciation disease in marine fish species. Toltrazuril exhibits antiparasitic effects; however, the simultaneous impacts of toltrazuril on parasites and hosts are unclear. Here, we evaluate the cytotoxicity of three commercial toltrazuril products (A, B and C) and the treatment efficacy against E ...
Young Juhn Lee +4 more
wiley +1 more source
Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi
Advanced Science, Volume 12, Issue 37, October 6, 2025.The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda +12 more
wiley +1 more source
Fumagillin, an efficacious drug against renal sphaerosporosis of the common carp Cyprinus carpio [PDF]
, 1987 At present no reliable and efficacious drugs are available for treating fish diseases caused by myxosporeans. By feeding Fumagillin DCH salt in the diet, the authors achieved very promising results in controlling renal sphaerosporosis, one of the ...
Baska, Ferenc +2 more
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