Results 131 to 140 of about 2,909 (219)

Achieving reimbursable PrEP is insufficient to increase and diversify the users attending community‐based services

HIV Medicine, EarlyView.
Abstract Objectives The reimbursement of HIV pre‐exposure prophylaxis (PrEP) in Italy was expected to increase uptake and diversify users. We assessed changes in PrEP initiation patterns before and after reimbursement at a community‐based service. Methods We conducted a monocentric retrospective cohort study that included all individuals who initiated ...
Enrico Caruso, Alessandro Tavelli, Anna De Bona, Nicoletta Frattini, Davide Moschese, Camilla Muccini, Daniele Tesoro, Alessandro Guido Soria, Alessandra Bianchi, Antonella D' Arminio Monforte, Massimo Cernuschi, Roberto Rossotti   +11 more
wiley   +1 more source

Transition from anti-CD20 therapies to fumarates as a treatment strategy: A multicenter, retrospective observational experience. [PDF]

Mult Scler J Exp Transl Clin
Vollmer BL, Hoyt T, West TW, Gutman J, Benitez M, Riddle EL, Lewin JB, Mendoza JP, Alvarez E.   +8 more
europepmc   +1 more source

Treatment durability, satisfaction and quality of life in virologically suppressed HIV‐1 people switching to doravirine: Results from the French study DoraVIH

HIV Medicine, EarlyView.
Abstract Objectives In Europe, most people with HIV‐1(PWH) achieve virologic suppression with effective and well‐tolerated antiretroviral therapies (ART). In this context, patient‐reported outcomes (PRO) are increasingly important for evaluating ART benefits.
Spire Bruno, Robineau Olivier, Pourcher Valérie, Loubet Paul, Palacios Christia, Jacomet Christine, Benachir Haydar, Mariot Philippe, Parienti Jean‐Jacques, Slama Laurence   +9 more
wiley   +1 more source

Maleic Anhydride and Its Derivatives: A Brief Review of Reactivity and Properties in Radical (Co)Polymerizations. [PDF]

Macromol Rapid Commun
Smith MP, Klumperman B.
europepmc   +1 more source

Clinical characteristics and follow‐up of 77 patients with pathogenic fumarate hydratase variants

BJU International, EarlyView.
Matthijs Duijn, Aline M. Tijans, R. Jeroen A. van Moorselaar, Marjoleine F. Broekema, Marleen E. de Lange, Emiel D. Post Uiterweer, Marilyne M. Lange, Naomi Donner, Markus V. Starink, Antoinette Hollestelle, Liselotte P. van Hest, Femke Struik, Patricia J. Zondervan   +12 more
wiley   +1 more source

Real‐world use of second‐generation integrase strand transfer inhibitors (INSTI) as switch therapy in the prospective ANRS‐CO3‐AquiVIH‐NA cohort

HIV Medicine, EarlyView.
Abstract Objectives To characterize real‐world treatment switching in France to bictegravir (BIC or B) or dolutegravir (DTG)‐based regimens with a focus on treatment persistence, effectiveness (HIV‐1 RNA ≤50 copies/ml) and particular attention to the prevalence and incidence of comorbidities. Methods People living with HIV from the prospective ANRS‐CO3‐
O. Leleux, A. Peyrouny‐Mazeau, A. Perrier, M. Hessamfar, G. Le Moal, D. Neau, L. Alleman, C. Cazanave, E. Lazaro, P. Duffau, A. Riché, Y. Gérard, G. Barrière, S. Reigadas, M.‐A. Vandenhende, F. Bonnet   +15 more
wiley   +1 more source

Phase 1 study of balinatunfib, an oral inhibitor of TNFR1 signal in mild‐to‐moderate psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Balinatunfib is the first oral, small molecule selective inhibitor of TNFR1 signaling. The results of this study indicate that balinatunfib treatment was tolerable with no serious or severe adverse events in patients with mild‐to‐moderate psoriasis and showed clinical responses.
Nassr Nassr, Ohn A. Chow, Mai Anh Nguyen, Laurent Perrin, Fabienne Schumacher, Frank‐Dietrich Wagner, Caroline Dreis, Amel Lahmar, Markus Kohlmann, Maria Wiekowski, Tiago R. Matos   +10 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Mitochondrial β‐carbonic anhydrase is a conserved metabolic rheostat for branched‐chain amino acid catabolism and metabolic flexibility

New Phytologist, EarlyView.
Summary Carbonic anhydrases (CAs) are ubiquitous metalloenzymes that catalyze the reversible hydration of CO2, enabling fundamental processes in organisms across all domains of life. Among all CAs, the role of mitochondrial βCA remains poorly understood. Here, we identify a mitochondrial βCA, βCA6, as a key regulator of branched‐chain amino acid (BCAA)
Naveen Sharma, Thomas D. Sharkey, Federica Brandizzi   +2 more
wiley   +1 more source

Dehydration‐driven organization of metabolites into NaDES‐like assemblies in orthodox seeds

New Phytologist, EarlyView.
Summary Desiccation tolerance in plants, especially during orthodox seed dehydration, relies on compatible solute accumulation, complex molecular mechanisms, and intermolecular organizations that remain poorly understood. We combined metabolite profiling, mass spectrometry imaging, and electrospray and cold‐spray ionization mass spectrometry to ...
Youcef Haddad, Thomas Delhaye, Emmanuelle Limanton, Denis Morineau, Maëna Le Corvec, Christine Deponge, Anne Levrel, Alain Moréac, Virginie Nazabal, David Rondeau, Ludovic Paquin, Alain Bouchereau   +11 more
wiley   +1 more source