Results 151 to 160 of about 2,275 (253)

Isosorbide Diesters: Mechanistic Insights and Therapeutic Applications in Skin and Neuroinflammatory Disorders. [PDF]

Int J Mol Sci
Chaudhuri RK, Meyer TA.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Monomethyl Fumarate Modulates Iron Metabolism and Mitochondrial Function in Microglia with Implications for Multiple Sclerosis Progression. [PDF]

Cell Mol Neurobiol
Dann J, Klöster K, Ceylan U, Heitmann N, Eggers B, Rozanova S, Eisenacher M, Marcus-Alic K, Winklhofer KF, Gold R, Faissner S.   +10 more
europepmc   +1 more source

Occupational Allergic Contact Dermatitis From Over‐Ear Headphones: Chemical Analysis Reveals Octylisothiazolinone and Other Potential Skin Sensitizers

Contact Dermatitis, EarlyView.
ABSTRACT Background Over‐ear headphones are a growing source of allergic contact dermatitis (ACD). Identifying well‐known and new culprit sensitizers in such products is challenging because of a lack of labelling and limited cooperation from manufacturers.
Goël Fenech, Eddy Langlois, Eric Pelletier, Catherine Champmartin, Lynda Bensefa‐Colas, Marie‐Noëlle Crepy   +5 more
wiley   +1 more source

Enhanced fumarate production using high-density cultivation of Synechocystis sp. PCC 6803. [PDF]

Microb Cell Fact
Iseki K, Iijima H, Ohneda S, Osanai T.
europepmc   +1 more source

Factors associated with drug adherence in psoriasis: a single‐center, retrospective, questionnaire‐based exploratory study in Bavaria

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Achieving sustained drug adherence in psoriasis remains challenging despite effective therapies. This exploratory study aims to investigate the care situation and factors associated with drug adherence in patients with moderate‐to‐severe psoriasis vulgaris (PsO). Patients and Methods A single‐center study was conducted
Negahr Jalili‐Tazeshahri, Gunnar Huppertz, Bernadett Kurz, Maria Isabel von Eichborn, Mark Berneburg, Tim Maisch, Dennis Niebel   +6 more
wiley   +1 more source

Dimethyl Fumarate vs. Monomethyl Fumarate: Unresolved Pharmacologic Issues. [PDF]

Pharmaceutics
Kopincova J, Bernatova I.
europepmc   +1 more source

Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Use of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 1 diabetes (T1D) is limited by increased risk of ketoacidosis. We aimed to determine metabolic pathways affected by SGLT2i treatment in adults with T1D during ketosis induced by insulin withdrawal.
Rosa Yang, Kevin Cho, Max C. Petersen, Kai E. Jones, Gary J. Patti, Janet B. McGill, Samantha A. DiGruccio   +6 more
wiley   +1 more source

Disproportionate pace of evidence-based care implementation in pediatric-onset multiple sclerosis: consequences and opportunities. [PDF]

Implement Sci Commun
Gambrah-Lyles C, Cole JJ, Ramsey AT.
europepmc   +1 more source

Prebiotic aqueous reactions catalyzed by native nickel without hydrogen

The FEBS Journal, EarlyView.
Serpentinizing (H2‐producing) hydrothermal vents are candidate environments for metabolic origin. They generate highly reducing conditions that convert CO2 to formate and methane in abiotic reactions resembling reactions of the acetyl‐CoA pathway of CO2 fixation. They also contain natural catalysts. Native nickel (Ni0), like Fe0, Co0, and their alloys,
Carolina Garcia Garcia, Max Brabender, William F. Martin   +2 more
wiley   +1 more source