Results 211 to 220 of about 2,275 (253)

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

open access: yesJournal of Experimental Medicine, 2011
Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th) cell differentiation. However, both diseases show opposing responses to most established therapies.
Kamran Ghoreschi   +2 more
exaly   +2 more sources

New substituted polymethylenes by free radical polymerization of bulky fumarates and their properties

open access: yesPolymer, 2000
The free radical polymerization of fumarates (DRFs) bearing sterically crowded ester groups was investigated. Various new monomers were synthesized and their polymerization behaviour was looked into. In bulk polymerizations at 60 degrees C initiated with
Pantoustier, N   +2 more
exaly   +2 more sources

Initiation in the free radical (co)polymerization of dialkyl fumarates and dicyclohexyl fumarate/tert-butyl vinyl ether investigated by a nitroxide trapping technique†

open access: yesPolymer International, 2003
Initiation in the free radical polymerization of dicyclohexyl fumarate (DCHF), isopropyl phenyl fumarate (iPPF) and isopropyl benzyl fumarate (iPBF), and the copolymerization of DCHF with tert-butyl vinyl ether (E), initiated by di-tert-butyl peroxalate,
Per B Zetterlund   +2 more
exaly   +2 more sources

Fumarates and Cancer

Trends in Molecular Medicine, 2017
Accumulation of intermediate metabolites of the tricarboxylic acid (TCA) cycle in tumor cells can cause epithelial-to-mesenchymal transition (EMT), although the exact mechanisms remain elusive. Recent studies show that the oncometabolite fumarate, which accumulates in fumarate hydratase-deficient renal cancers, confers tumor aggressiveness by causing ...
Fuhler, Gwenny   +2 more
openaire   +2 more sources

Fesoterodine fumarate

Drugs of Today, 2010
Overactive bladder (OAB) is a common condition that causes a profound impact on an individual's overall health and quality of life. Muscarinic antagonists are the mainstay of oral pharmacotherapy for OAB. The most-recently introduced muscarinic antagonist, fesoterodine fumarate, is unique in that the parent compound has no antimuscarinic efficacy due ...
A, Gomelsky, Roger R, Dmochowski
openaire   +2 more sources

Fumarate permeation in rat liver mitochondria: Fumarate/malate and fumarate/phosphate translocators

Biochemical and Biophysical Research Communications, 1985
Fumarate permeation in isolated rat liver mitochondria was demonstrated by measuring malate and phosphate efflux caused by fumarate added externally to the mitochondrial suspension. The existence of two specific fumarate translocators, fumarate/malate and fumarate/phosphate, is shown here.
Atlante A   +3 more
openaire   +4 more sources

2-Aminopyridinium–fumarate–fumaric acid (2/1/1)

Acta Crystallographica Section C Crystal Structure Communications, 2004
The title complex, 2C5H7N2+.C4H2O42-.C4H4O4, contains cyclic eight-membered hydrogen-bonded rings involving 2-aminopyridinium and fumarate ions. The fumaric acid molecules and fumarate ions lie on inversion centers and are linked into zigzag chains by O-H...O hydrogen bonds.
Büyükgüngör, Orhan   +3 more
openaire   +2 more sources

Tenofovir Disoproxil Fumarate

Drugs, 2003
Tenofovir disoproxil fumarate (tenofovir DF) is a prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor. In two large, well designed, placebo-controlled clinical trials, tenofovir DF 300 mg/day resulted in significant reductions in HIV-1 RNA from baseline compared with placebo at 24 weeks in antiretroviral-experienced patients with HIV ...
Therese, Chapman   +2 more
openaire   +2 more sources

Triethylammonium hydrogen fumarate

Acta Crystallographica Section C Crystal Structure Communications, 2000
In crystals of the title compound, the hydrogen fumarate anions form one-dimensional chains through an O-H.O hydrogen bonding along the c and (a+b)/2 directions. There are three sites of the hydrogen fumarate, two of which have an inversion centre.
Hosomi, H, Ohba, S, Ito, Y
openaire   +2 more sources

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