Results 61 to 70 of about 12,559 (263)

50 Years of Giese Reaction – a Personal View

Angewandte Chemie, EarlyView.
The Giese‐Reaction celebrates its 50. Birthday, it is a cyclic radical chain reaction centered around C,C‐bond formation in a three component synthesis. This minireview speaks about the birth of the name‐reaction, explains how the complete understanding of its reaction mechanism stimulates new methods in organic synthesis, and why it can proceed in ...
Martin Spichty, Hendrik Zipse, Salem Majouri, Katharina M. Fromm, Bernd Giese   +4 more
wiley   +2 more sources

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Combining Electrochemical Reduction with Biosynthesis for Directed Conversion of CO2 into a Library of C3 Chemicals

Advanced Science, EarlyView.
In the H‐type electrolytic cell, carbon dioxide is reduced to acetic acid via electro‐microbial catalysis. The simply processed acetic acid is further converted through biological fermentation into high‐value‐added products, including acrylic acid, L‐lactic acid, and β‐alanine.
Kaixing Xiao, Shanquan Liang, Xujun Zhao, Zhiyao Peng, Ruoshi Luo, Jikai Zong, Ling Zhou, Yude Su, Dan Wang   +8 more
wiley   +1 more source

Assessment of Symptoms Control, Pulmonary Function and Related Quality of Life in Asthmatic Patients Treated with Extrafine Beclomethasone Dipropionate/Formoterol Fumarate 100/6 μg pMDI: Results of a Multicenter Observational Study in Romania (ALFRESCO Study)

, 2022
Ruxandra Ulmeanu, Sebastian Bloju, Oana Vittos   +2 more
openalex   +2 more sources

Effect of Imidazolium Concentration in Densely Functional Polymer Binder on Robust Electrochemical Kinetics and Cycling Performance of Lithium Iron Phosphate Cathode

Advanced Energy and Sustainability Research, EarlyView.
The improved performance of the cathodic half‐cell containing poly(oxycarbonylmethylene 1‐allyl‐3‐methylimidazolium) (PMAI) binder (PMAI/LFP) is attributed to the ion conduction properties of imidazolium‐functionalized polymer, which participates in cathode‐electrolyte interphase (CEI) formation as confirmed by X‐ray photoelectron spectroscopy and ...
Amarshi Patra, Zhaohan Liu, Pavithra Kasthurirangan, Noriyoshi Matsumi   +3 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Evolving Patterns of Initial RRMS Treatment in Finland (2013–2022): Insights From a Nationwide Multiple Sclerosis Register

Brain and Behavior
Background The treatment of relapsing‐remitting multiple sclerosis (RRMS) is changing. There are limited data about initial treatment of RRMS in Finland. Objective Our objectives were to study the trends of initial disease‐modifying treatments (DMTs) for
Henrik Ahvenjärvi, Elina Jokinen, Matias Viitala, Henri Autio, Anne M. Portaankorva, Merja Soilu‐Hänninen, Johanna Krüger, Mervi Ryytty   +7 more
doaj   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

From Diagnosis to Disease Staging: Multisite Validation of Cerebrospinal Fluid Molecular Tests in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The growing demand for personalized treatment in multiple sclerosis (MS) highlights the need for more precise biomarkers that can outperform magnetic resonance imaging and clinical assessment in patient stratification. Advances in multiplex proteomic technologies suggest that cerebrospinal fluid (CSF) analysis at MS onset may not only improve
Laura Ghezzi, Peter Kosa, Mark Greenwood, Enrique Alvarez, C.L. Freedman, Anne H. Cross, Francesca Pace, Mark S. Freedman, Joanna Kocot, Laura Piccio, Bibiana Bielekova   +10 more
wiley   +1 more source

Fumar ou não fumar, eis... Zeno [PDF]

Revista Latinoamericana de Psicopatologia Fundamental, 2012
E sempre bom desconfiar de textos iniciando com perguntas aoleitor. Pois este tem inicio nao com uma, mas duas: por que as proi-bicoes impostas pela moral, pela etica, pela sociedade nao sao levadasa cabo em sua totalidade? O que haveria na proibicao de tao tentador?Geoffrey Chaucer, o escritor ingles do medievo, contempla a res-posta a essas questoes ...
openaire   +4 more sources