Results 61 to 70 of about 2,909 (219)

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. [PDF]

, 2018
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
A Cleasby, A Dhar, A Kobayashi, A Moraru, A Shevchenko, A Uruno, AC Ruifrok, Arnab K. Chatterjee, BR Sabari, BT Weinert, CL Saw, Claudio Zambaldo, D Martinez Molina, DD Zhang, Emily N. Chin, FW Chaplen, Gihoon Lee, GP Sykiotis, GR Wagner, H Lin, Hwayoung Yun, Insha Ahmad, Jae Won Chang, John S. Coukos, JW Chang, Luke L. Lairson, M Ravichandran, MC Jaramillo, Michael J. Bollong, N Rabbani, N Rabbani, N Wakabayashi, Peter G. Schultz, Raymond E. Moellering, RE Moellering, RH Scannevin, S Nishimoto, S Tao, SC Lo, T Bücher, T Ogura, TB El-Abaseri, TO Khor, TW Lo, W Hur, W Hur, Y Mitsuishi, Z Zhang   +47 more
core   +2 more sources

Rational Fine‐Tuning of MOF Pore Metrics: Enhanced SO2 Capture and Sensing with Optimal Multi‐Site Interactions

Advanced Functional Materials, EarlyView.
A pore tuning strategy to amplify the multi‐site MOF‐SO2 interactions is proposed to achieve an enhanced trace SO2 capture and chemiresistive sensing in highly stable isostructural DMOFs by annelating benzene rings. This work provides a facile strategy to achieve tailor‐made stable MOF materials for specific multifunctional applications.
Shanghua Xing, Abdulrahman Mohabbat, István Boldog, Jens Möllmer, Marcus Lange, Yulyan Haiduk, Tobias Heinen, Vladimir Pankov, Oliver Weingart, Christoph Janiak   +9 more
wiley   +1 more source

Lymphocyte dynamics in patients with multiple sclerosis who were treated with dimethyl fumarate and subsequently switched to diroximel fumarate

Brain Disorders
Objective: Dimethyl fumarate (DMF) and diroximel fumarate (DRF) are oral multiple sclerosis (MS) disease-modifying therapies (DMTs). Absolute lymphocyte count (ALC) dynamics are similar for DMF and DRF, but have not been investigated in patients who ...
Shauna M. Gales, Ahmed Z. Obeidat, Andreina Neall, Kermit A. Lloyd, Nicholas Belviso, Seth Levin, Ivan Bozin, Jason P. Mendoza, James B. Lewin, Michael D. Kornberg   +9 more
doaj   +1 more source

Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery [PDF]

, 2016
Novel maleimide-functionalised nanogels have been synthesised via the polymerisation of 2,5-dimethylfuran-protected 3-maleimidoethyl butylacrylate in the presence of presynthesised poly(N-vinylpyrrolidone) (PVP) nanogel scaffolds using surfactant-free ...
Andrews, Bernkop-Schnurch, Bernkop-Schnürch, Boddupalli, Chacko, Cook, Davidovich-Pinhas, Davidovich-Pinhas, Ellman, Fontaine, Hasegawa, Hayashi, Irmukhametova, Kao, Khutoryanskiy, Khutoryanskiy, Li, Li, Lowe, Ludwig, Mantovani, Maya, Molina, Morales, Nair, Northrop, Peppas, Prosperi-Porta, Schmitz, Shaikh, Singhvi, Sosnik, Storha, Syrett, Valenta, Wagh, Xu, Yang   +37 more
core   +1 more source

Inactivating SARS‐CoV‐2 Virus with MOF‐Composites as Smart Face Masks

Advanced Functional Materials, EarlyView.
In situ preparation and functionalization of MOF@Cotton fabrics as smart face masks for the immobilization of proteins and inactivation viruses, such as SARS‐CoV‐2. Abstract The significant impact of the SARS‐CoV‐2 (COVID‐19) pandemic outbreak on people's lives has highlighted the urgent need for effective personal protective equipment.
Romy Ettlinger, Aamod V. Desai, Hau Lam Jody Cheong, Louise L. Major, Terry K. Smith, Aaron B. Naden, Jane Hilton, Catherine S. Adamson, A. Robert Armstrong, Russell E. Morris   +9 more
wiley   +1 more source

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases [PDF]

, 2018
Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time of this small, reactive compound implicating ...
Andersen, Jacob Lauwring, Arthur, J. Simon C., Funder, Erik Daa, Gesser, Borbala, Gotfred-Rasmussen, Helle, Gothelf, Kurt Vesterager, Iversen, Lars, Nielsen, Christine Juul Fælled, Nissen, Poul, Rasmussen, Mads Kirchheiner, Toth, Rachel   +10 more
core   +3 more sources

Block Copolymers: Emerging Building Blocks for Additive Manufacturing

Advanced Functional Materials, EarlyView.
This review addresses how block copolymer (BCP) physics and rheology have led to the widespread use of BCPs in advanced additive manufacturing techniques, with particular emphasis on the untapped potential of these nanostructured materials toward achieving multi‐scale architected materials with unique, programmable material properties.
Alice S. Fergerson, Hemish B. Thakkar, Jiaen Wu, Emily C. Davidson   +3 more
wiley   +1 more source

Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis. [PDF]

, 2014
Multiple sclerosis (MS) is a life-long, potentially debilitating disease of the central nervous system (CNS). MS is considered to be an immune-mediated disease, and the presence of autoreactive peripheral lymphocytes in CNS compartments is believed to be
A Compston, A Groves, A Kulakowska, A Miravalle, A Prat, A Shirani, AJ Coles, AL Cox, AM Palmer, B Balatoni, B Bielekova, BJ Oliver, C Boulton, C Brunmark, C Confavreux, C Saure, C Wegner, CH Polman, CL Mackall, D Azoulay, D Burger, D Cadavid, D Hunt, D Moharregh-Khiabani, D Moharregh-Khiabani, D Wynn, Daniel D. Pinschewer, DD Mikol, DD Pinschewer, DD Pinschewer, DD Pinschewer, DK Sato, Doron Merkler, DS Goodin, EM Frohman, F Martinelli Boneschi, F Rinaldi, F Santo Del, FD Lublin, G Bloomgren, G Comi, G Guarda, G Pilz, GA Kolumam, GM DeNicola, GP Rice, H Panitch, H Schmidt, HM Cherwinski, HP Hartung, I Metz, IL Tan, J Booss, J Chun, J Hanson, J Killestein, J Rio, JA Cohen, JA Cohen, JA Cohen, JC Lehmann, JF McDyer, JL McQualter, JR Berger, JS Yang, JW Choi, KA Brown, KA Buzzard, KB Walsh, KD Held, KJ Bayless, KP Johnson, L Durelli, L Kappos, L Kappos, L Klotz, LD Jacobs, LF Voort van der, LK Peterson, M Chen, M Gurevich, M Kala, M Mehling, M Mehling, M Meissner, M Prinz, M Skarica, M Vandermeeren, M Zeyda, MA Zarbin, MC Kraan, ME Kozovska, MJ Glennie, MK Racke, MM Vellinga, MQ Xia, MT Sweetser, N Koch-Henriksen, N Putzki, N Qizilbash, NS Roskell, O Fernandez, O Neuhaus, OJ Leger, P Kivisakk, P Maddison, P O’Connor, P O’Connor, P Vermersch, PS Sorensen, R Aspinall, R Deogracias, R Doorn van, R Gold, R Gold, R Milo, R Tanasescu, RA Bermel, RA Linker, RA Rudick, RC Selter, Renaud A. Du Pasquier, RH Scannevin, RJ Fox, S Dhib-Jalbut, S Jilek, S Marousi, S Nikfar, S Philipp, SC Steinberg, SJ Jackson, SK Manna, SP Morrissey, SR Mirandola, T Fujita, T Kuhlmann, T Ziemssen, TW West, TW West, V Brinkmann, V Brinkmann, V Parfenov, V Popescu, W Bruck, X Xu, X Xu   +145 more
core   +3 more sources

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides [PDF]

, 2014
Catalytic asymmetric 1,3-dipolar cycloadditions of azomethine ylides have turned out to be one of the most efficient methods for the preparation of enantioenriched pyrrolidines.
Adrio, Javier, Carretero, Juan C.
core   +2 more sources