Results 61 to 70 of about 3,137 (203)

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells [PDF]

, 2016
Recessive mutations in the MPV17 gene cause mitochondrial DNA depletion syndrome, a fatal infantile genetic liver disease in humans. Loss of function in mice leads to glomerulosclerosis and sensineural deafness accompanied with mitochondrial DNA ...
A Rokka, A Spinazzola, A Trott, AM Meyer zum Gottesberge, AW El-Hattab, C Viscomi, CJ Binder, CL Karadimas, Elmon Schmelzer, H Pircher, H Weiher, Hans Weiher, Hans Will, Haymo Pircher, ID Rosa, J Krauss, J Schenkel, J Uusimaa, J. Kalervo Hiltunen, K Kaldi, Kerstin Reumann, M Karasawa, Miia Vapola, N Papeta, Percy Knolle, Pidder Jansen-Dürr, R Iida, R Reinhold, Ralf M. Zwacka, RM Zwacka, S Kinkley, S Löllgen, Silke Grunau, Silke Hegenbarth, T O’Bryan, U Brosius, VD Antonenkov, WC Copeland   +37 more
core   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Efficient test for nonlinear dependence of two continuous variables [PDF]

, 2015
The power comparison of simulation study across Gaussian noise levels (mean = 0, variance = 1/9, 1/4, 4 and 9).
Hongbao Cao, Li Jin, Momiao Xiong, Yi Li, Yi Wang, Yin Yao Shugart   +5 more
core   +3 more sources

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.

PLoS Genetics, 2006
Viruses and transposons are efficient tools for permanently delivering foreign DNA into vertebrate genomes but exhibit diminished activity when cargo exceeds 8 kilobases (kb).
Darius Balciunas, Kirk J Wangensteen, Andrew Wilber, Jason Bell, Aron Geurts, Sridhar Sivasubbu, Xin Wang, Perry B Hackett, David A Largaespada, R Scott McIvor, Stephen C Ekker   +10 more
doaj   +1 more source

Synergistic Roles of FAHD‐1 and PYC‐1 in Mitochondrial Function, Behavior, and Longevity in C. elegans

Advanced Biology, Volume 10, Issue 1, January 2026.
FAHD‐1 and PYC‐1 catalyze opposing mitochondrial reactions that regulate oxaloacetate homeostasis in Caenorhabditis elegans. Using single and double knockouts, this study reveals that both enzymes shape locomotion, reproduction, respiration, and lifespan.
Riccardo Giaquinta, Andreas Andric, Matthias Scheppach, Alexander K. H. Weiss   +3 more
wiley   +1 more source

Role of Monocyte Chemoattractant Protein-1 During Liver Regeneration [PDF]

, 2015
Liver regeneration is a complex process that requires the coordinated expression of cytokines and growth factors. One well-studied model of liver regeneration is partial hepatectomy (PH), in which removal of 70% of the liver initiates compensatory ...
Wyler, Stephanie
core   +1 more source

Differential diagnosis of (inherited) amino acid metabolism or transport disorders [PDF]

, 1992
__Abstract__ Disorders of amino acid metabolism or transport are most clearly expressed in urine. Nevertheless the interpretation of abnormalities in urinary amino acid excretion remains difficult. An increase or decrease of almost every amino acid in
Blom, W.A.M. (Wim), Huijmans, J.G.M. (Jan)   +1 more
core   +2 more sources

Mechanistic Inferences from the Crystal Structure of Fumarylacetoacetate Hydrolase with a Bound Phosphorus-based Inhibitor [PDF]

Journal of Biological Chemistry, 2001
Fumarylacetoacetate hydrolase (FAH) catalyzes the hydrolytic cleavage of a carbon-carbon bond in fumarylacetoacetate to yield fumarate and acetoacetate as the final step of Phe and Tyr degradation. This unusual reaction is an essential human metabolic function, with loss of FAH activity causing the fatal metabolic disease hereditary tyrosinemia type I (
R L, Bateman, P, Bhanumoorthy, J F, Witte, R W, McClard, M, Grompe, D E, Timm   +5 more
openaire   +2 more sources

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

P-hydroxyphenylpyruvate, an intermediate of the Phe/Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shock [PDF]

, 2014
The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show
A Famili, A Leelahavanichkul, AB Peitzman, AJ Dickson, Antonella Cotoia, AV Kuznetsov, CA Macias, CA Macias, CB Cairns, Claudia Piccoli, E Bennett-Guerrero, Gilda Cinnella, HB Lantum, JH Taylor, Julia V. Gefter, KE Mulier, KJ Shah, KK Kao, KM Robinson, L Riddez, Luca Scorrano, Michele Dambrosio, Mitchell P. Fink, N Ke, Nazzareno Capitanio, R Yang, RJ Probst, RJ Sappington PL Cruz Jr, Rosella Scrima, S Kaufman, SD Varma, SW Kim, TM Owens, ZS Tawadrous   +33 more
core   +2 more sources