Results 131 to 140 of about 373,199 (312)

Mathematical Generalization of Kolmogorov-Arnold Networks (KAN) and Their Variants

open access: yesMathematics
Neural networks have become a fundamental tool for solving complex problems, from image processing and speech recognition to time series prediction and large-scale data classification.
Fray L. Becerra-Suarez   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Fuzzy and Tile Coding Approximation Techniques for Coevolution in Reinforcement Learning

open access: yes, 2005
This thesis investigates reinforcement learning algorithms suitable for learning in large state space problems and coevolution. In order to learn in large state spaces, the state space must be collapsed to a computationally feasible size and then ...
Laurissa Nadia Tokarchuk   +1 more
core  

The performance of available methods for computing the polynomial coefficients of the quadratic function approximation is evaluated. By comparing the numerical results to those obtained by symbolic methods, for a variety of functions, the direct solution of the matrix equation and a variety of recursive algorithms are all shown to be numerically unstable. AMS classification [PDF]

open access: yes, 1991
The performance of available methods for computing the polynomial coefficients of the quadratic function approximation is evaluated. By comparing the numerical results to those obtained by symbolic methods, for a variety of functions, the direct solution
McInnes, A.W., Balakrishnan, Easwaran
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Moment information for probability distributions, without solving the moment problem, II: Main-mass, tails and shape approximation

open access: yes, 2009
How much information does a small number of moments carry about the unknown distribution function? Is it possible to explicitly obtain from these moments some useful information, e.g., about the support, the modality, the general shape, or the tails of a
Athanassoulis, G.A.   +3 more
core   +1 more source

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