Results 161 to 170 of about 5,939,728 (334)

Theory I: Deep networks and the curse of dimensionality [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2018
T. Poggio, Q. Liao
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Effect of Transformations on the Approximation of Univariate (Convex) Functions with Applications to Pareto Curves [PDF]

In the literature, methods for the construction of piecewise linear upper and lower bounds for the approximation of univariate convex functions have been proposed.We study the effect of the use of increasing convex or increasing concave transformations ...
Siem, A.Y.D., Hertog, D. den, Hoffmann, A.L.   +2 more
core  

Approximation Performance Analysis and Application of F Characteristics in Fractance Approximation Circuit

四川大学学报. 自然科学版, 2018
F-frequency characteristics function is a new concept about lumped eigenvalue of the fractance approximation circuit. In order to quantitatively describe the approximation performance of F-frequency characteristics of the fractance approximation circuit,
YU Bo, HE Qiu-Yan, YUAN Xiao, YANG Li-Xian   +3 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

KANs for deuteron wave function approximation with simplified chiral EFT. [PDF]

Sci Rep
Khalili H, Shabani A, Marzabadi MA, Khalili M.   +3 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A shape control and object manipulation technique based on function approximation for robotic surfaces. [PDF]

Front Robot AI
Zhao Y, Chen Y.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Efficient nonlinear function approximation in analog resistive crossbars for recurrent neural networks. [PDF]

Nat Commun
Yang J, Mao R, Jiang M, Cheng Y, Sun PV, Dong S, Pedretti G, Sheng X, Ignowski J, Li H, Li C, Basu A.   +11 more
europepmc   +1 more source