Results 1 to 10 of about 3,895,541 (330)

Differential molecular response in mice and human thymocytes exposed to a combined-dose radiation regime

open access: yesScientific Reports, 2022
In the quest for more effective radiation treatment options that can improve both cell killing and healthy tissue recovery, combined radiation therapies are lately in the spotlight.
Pilar López-Nieva   +8 more
doaj   +1 more source

The antitumor activity of cannabidiol on lung cancer cell lines A549 and H1299: the role of apoptosis

open access: yesBiotechnology & Biotechnological Equipment, 2021
In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova   +4 more
doaj   +1 more source

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes

open access: yesNature Communications, 2022
Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte ...
Ji Seul Han   +14 more
doaj   +1 more source

Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes

open access: yesScientific Reports, 2021
By interacting with the mRNA 5′ cap, the translation initiation factor eIF4E plays a critical role in selecting mRNAs for protein synthesis in eukaryotic cells.
Ebelechukwu C. Nwokoye   +6 more
doaj   +1 more source

Application of Snakehead Fish to Increase Liver Function of Rats after Experiencing Physiological Stress

open access: yesBiosaintifika: Journal of Biology & Biology Education, 2018
Physiological stress due to nutritional deficiency accompanied by excessive activity can cause problems of energy deficiency required by the body. Energy shortage can affect the body weight, as well as the weight and histology of the liver.
Sunarno Sunarno   +2 more
doaj   +1 more source

Cinnamon and Gotu Kola Supplementation to Produce High Antioxidant and Low Cholesterol of Quail Pectoral Meat

open access: yesBiosaintifika: Journal of Biology & Biology Education, 2019
Cholesterol in quail meat is one of the factors causing consumers to control consumption of quail meat. On the other hand, the antioxidant content in quail meat could attracts the consumers. Cinnamon (Cinnamomum sp.) bark and gotu kola (Centella asiatica)
Sunarno Sunarno   +4 more
doaj   +1 more source

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays

open access: yesMolecular Systems Biology, 2009
Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain.
Avinash Persaud   +8 more
doaj   +1 more source

Mitochondria Biology in Reproductive Function

open access: yesAntioxidants, 2022
Mitochondria are multitasking organelles involved in the maintenance of cell homeostasis [...]
Carla Tatone, Giovanna Di Emidio
doaj   +1 more source

Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies

open access: yesBiomolecules, 2021
Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes. These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma haematobium being one of the species that mainly affect humans. There is a lack of
Neo Padi   +5 more
doaj   +1 more source

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling

open access: yesCells, 2021
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson   +2 more
doaj   +1 more source

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