Results 181 to 190 of about 14,444,288 (391)
Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder +7 morewiley +1 more sourceTranscriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle +14 morewiley +1 more sourceTargeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti +10 morewiley +1 more sourceThermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′ Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar +10 morewiley +1 more sourceGenetic studies of body mass index yield new insights for obesity biology
Nature, 2015 A. Locke, Bratati Kahali, S. Berndt, A. Justice, T. Pers, F. Day, Corey Powell, S. Vedantam, Martin L. Buchkovich, Jian Yang, Damien C. Croteau-Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J. Randall, T. Winkler, A. Wood, T. Workalemahu, J. Faul, Jennifer A. Smith, J. Zhao, Wei Zhao, Jin Chen, R. Fehrmann, Å. Hedman, J. Karjalainen, Ellen M. Schmidt, D. Absher, N. Amin, Denise Anderson, M. Beekman, J. Bolton, J. Bragg-Gresham, S. Buyske, A. Demirkan, Guohong Deng, G. Ehret, B. Feenstra, M. Feitosa, K. Fischer, A. Goel, Jian Gong, A. Jackson, S. Kanoni, M. Kleber, K. Kristiansson, U. Lim, Vaneet Lotay, M. Mangino, I. M. Leach, C. Medina-Gomez, S. Medland, M. Nalls, Cameron D. Palmer, D. Pasko, S. Pechlivanis, M. Peters, I. Prokopenko, D. Shungin, A. Stančáková, R. Strawbridge, Y. Sung, Toshiko Tanaka, A. Teumer, S. Trompet, S. W. Laan, J. V. Setten, J. V. Vliet-Ostaptchouk, Zhaoming Wang, L. Yengo, Weihua Zhang, A. Isaacs, E. Albrecht, J. Ärnlöv, Gillian M. Arscott, A. Attwood, S. Bandinelli, Amy Barrett, Isabelita N. Bas, C. Bellis, A. Bennett, C. Berne, R. Blagieva, M. Blüher, S. Böhringer, L. Bonnycastle, Y. Böttcher, H. Boyd, M. Bruinenberg, I. H. Caspersen, Y. I. Chen, R. Clarke, E. W. Daw, A. Craen, G. Delgado, M. Dimitriou, A. Doney, N. Eklund, K. Estrada, Elodie Eury, L. Folkersen, Ross M. Fraser, M. Garcia, F. Geller, V. Giedraitis, B. Gigante, A. Go, A. Golay, A. Goodall, S. Gordon, Mathias Gorski, H. Grabe, H. Grallert, T. Grammer, J. Grässler, H. Grönberg, C. Groves, G. Gusto, J. Haessler, P. Hall, T. Haller, G. Hallmans, C. Hartman, M. Hassinen, C. Hayward, N. Heard-Costa, Q. Helmer, C. Hengstenberg, O. Holmen, J. Hottenga, A. James, Janina M. Jeff, Å. Johansson, J. Jolley, Thorhildur Juliusdottir, L. Kinnunen, W. Koenig, M. Koskenvuo, W. Kratzer, J. Laitinen, C. Lamina, K. Leander, N. Lee, P. Lichtner, L. Lind, J. Lindström, K. S. Lo, S. Lobbens, R. Lorbeer, Yingchang Lu, F. Mach, P. Magnusson, A. Mahajan, W. McArdle, S. McLachlan, C. Menni, S. Merger, E. Mihailov, L. Milani, A. Moayyeri, K. Monda, M. Morken, A. Mulas, G. Müller, M. Müller-Nurasyid, A. Musk, R. Nagaraja, M. Nöthen, I. Nolte, S. Pilz, N. W. Rayner, Frida Renstrom, R. Rettig, J. Ried, S. Ripke, N. Robertson, L. Rose, S. Sanna, H. Scharnagl, S. Scholtens, F. Schumacher, W. Scott, T. Seufferlein, Jianxin Shi, A. Smith, Joanna Smolonska, A. Stanton, V. Steinthorsdottir, K. Stirrups, H. Stringham, J. Sundström, M. Swertz, A. Swift, A. Syvänen, S. Tan, B. Tayo, B. Thorand, G. Thorleifsson, J. Tyrer, H. Uh, L. Vandenput, F. Verhulst, S. Vermeulen, N. Verweij, J. Vonk, L. Waite, H. Warren, D. Waterworth, M. Weedon, L. Wilkens, C. Willenborg, T. Wilsgaard, M. Wojczynski, A. Wong, A. Wright, Qunyuan Zhang, E. Brennan, Murim Choi, Z. Dastani, A. Drong, P. Eriksson, A. Franco-Cereceda, J. Gådin, A. Gharavi, M. Goddard, R. Handsaker, Jinyan Huang, F. Karpe, S. Kathiresan, S. Keildson, K. Kiryluk, M. Kubo, Jong-Young Lee, L. Liang, R. Lifton, Baoshan Ma, S. Mccarroll, A. McKnight, J. Min, M. Moffatt, G. Montgomery, J. Murabito, G. Nicholson, D. Nyholt, Y. Okada, J. Perry, R. Dorajoo, E. Reinmaa, R. Salem, N. Sandholm, R. Scott, L. Stolk, A. Takahashi, Toshihiro Tanaka, F. V. Hooft, Anna A. E. Vinkhuyzen, H. Westra, W. Zheng, K. Zondervan, A. Heath, D. Arveiler, S. Bakker, J. Beilby, R. Bergman, J. Blangero, P. Bovet, H. Campbell, M. Caulfield, G. Cesana, A. Chakravarti, D. Chasman, P. Chines, F. Collins, D. Crawford, L. Cupples, D. Cusi, J. Danesh, U. Faire, H. M. Ruijter, A. Dominiczak, R. Erbel, J. Erdmann, J. Eriksson, M. Farrall, S. Felix, E. Ferrannini, J. Ferrières, I. Ford, N. Forouhi, T. Forrester, O. Franco, R. Gansevoort, P. Gejman, C. Gieger, O. Gottesman, V. Gudnason, U. Gyllensten, A. Hall, T. Harris, A. Hattersley, A. Hicks, L. Hindorff, A. Hingorani, A. Hofman, G. Homuth, G. K. Hovingh, S. Humphries, S. Hunt, E. Hyppönen, T. Illig, K. Jacobs, M. Jarvelin, K. Jöckel, B. Johansen, P. Jousilahti, J. Jukema, A. Jula, J. Kaprio, J. Kastelein, S. Keinanen-Kiukaanniemi, L. Kiemeney, P. Knekt, J. Kooner, C. Kooperberg, P. Kovacs, A. Kraja, M. Kumari, J. Kuusisto, T. Lakka, C. Langenberg, L. Marchand, T. Lehtimäki, V. Lyssenko, S. Männistö, A. Marette, T. Matise, C. McKenzie, B. McKnight, F. Moll, A. Morris, A. Morris, J. Murray, M. Nelis, C. Ohlsson, A. Oldehinkel, K. Ong, P. Madden, G. Pasterkamp, J. Peden, A. Peters, D. Postma, P. Pramstaller, J. Price, L. Qi, O. Raitakari, T. Rankinen, D. Rao, T. Rice, P. Ridker, J. Rioux, M. Ritchie, I. Rudan, V. Salomaa, N. Samani, J. Saramies, M. Sarzynski, H. Schunkert, P. Schwarz, P. Sever, A. Shuldiner, J. Sinisalo, R. Stolk, K. Strauch, A. Tönjes, D. Trégouët, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, U. Völker, G. Waeber, G. Willemsen, J. Witteman, M. Zillikens, L. Adair, P. Amouyel, F. Asselbergs, T. Assimes, M. Bochud, B. Boehm, E. Boerwinkle, S. Bornstein, E. Bottinger, C. Bouchard, S. Cauchi, J. Chambers, S. Chanock, R. Cooper, P. D. Bakker, G. Dedoussis, L. Ferrucci, P. Franks, P. Froguel, L. Groop, C. Haiman, A. Hamsten, J. Hui, D. Hunter, K. Hveem, R. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Yongmei Liu, N. Martin, W. März, M. Melbye, A. Metspalu, S. Moebus, P. Munroe, I. Njølstad, B. Oostra, C. Palmer, N. Pedersen, M. Perola, L. Pérusse, U. Peters, C. Power, T. Quertermous, R. Rauramaa, F. Rivadeneira, T. Saaristo, D. Saleheen, N. Sattar, E. Schadt, D. Schlessinger, P. Slagboom, H. Snieder, T. Spector, U. Thorsteinsdóttir, M. Stumvoll, J. Tuomilehto, A. Uitterlinden, M. Uusitupa, P. Harst, M. Walker, H. Wallaschofski, N. Wareham, H. Watkins, D. Weir, H. Wichmann, James F. Wilson, P. Zanen, I. Borecki, P. Deloukas, C. Fox, I. Heid, J. O’Connell, D. Strachan, K. Stefánsson, C. Duijn, G. Abecasis, L. Franke, T. Frayling, M. McCarthy, P. Visscher, A. Scherag, C. Willer, M. Boehnke, K. Mohlke, C. Lindgren, J. Beckmann, I. Barroso, K. North, E. Ingelsson, J. Hirschhorn, R. Loos, Elizabeth K. Speliotes +481 moresemanticscholar +1 more sourceElucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam +8 morewiley +1 more source
