Results 211 to 220 of about 3,539,296 (346)

Critical importance of the correction of contrast transfer function for transmission electron microscopy-mediated structural biology [PDF]

, 2013
Hyeongseop Jeong, Hyo-Nam Park, Jin-Gyu Kim, Jaekyung Hyun   +3 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Biology and Function of Fetal and Pediatric Skin [PDF]

, 2013
Alice King, Swathi Balaji, Sundeep G. Keswani   +2 more
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Unravelling the Complexity of Sarcopenia Through a Systems Biology Approach. [PDF]

Int J Mol Sci
Ceyhan AB, Altay O, Zhang C, Temel SG, Turkez H, Mardinoglu A.   +5 more
europepmc   +1 more source

Revealing the Functions of the Transketolase Enzyme Isoforms in Rhodopseudomonas palustris Using a Systems Biology Approach

, 2011
Chia-Wei Hu, Ya-Ling Chang, Shiang Jiuun Chen, Ling-Long Kuo-Huang, James C. Liao, Hsuan‐Cheng Huang, Hsueh‐Fen Juan   +6 more
openalex   +2 more sources

Chemical Biology Strategies for Posttranslational Control of Protein Function [PDF]

, 2014
Rishi Rakhit, Raul Navarro, Thomas J. Wandless   +2 more
openalex   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

The Role of AI-Driven De Novo Protein Design in the Exploration of the Protein Functional Universe. [PDF]

Biology (Basel)
Zhang G, Liu C, Lu J, Zhang S, Zhu L.
europepmc   +1 more source